2021, Number 2
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Rev Biomed 2021; 32 (2)
Deep brain stimulation for Parkinson's disease: selection criteria, surgical approach, side effects, and controversies
Leal-Ortega R
Language: Spanish
References: 49
Page: 113-123
PDF size: 535.82 Kb.
ABSTRACT
Parkinson’s disease (PD) is the second most common neurodegenerative
disease. It aff ects 6 million people worldwide and this amount will
increase in the upcoming years. Management consists of a combination
of drugs, physical therapy, and advanced therapies that include devices
for parenteral use (apomorphine pumps and intestinal levodopa),
ablative surgery, and functional surgery. Deep brain stimulation (DBS)
is a modality in which electrical stimuli is delivered through electrodes
implanted in deep nuclei of the brain that are connected to a pulse
generator; it is a technique used worldwide with more than 150,000
operated patients. This procedure can control motor and some nonmotor
symptoms that have been failed to control by medical treatment.
Briefl y, a good candidate for DBS is one who has had PD for at least
5 years, a good response to levodopa, motor complications from
treatment, and an adequate cognitive-psychiatric profi le. During the
procedure, the neurosurgeon uses stereotactic coordinates to direct the
electrodes to the selected nucleus while the neurologist monitors cell
physiology so they can be placed in the exact site. There are signifi cant
but preventable and treatable complications during the procedure and
postoperatively. In 2016, our team performed the fi rst surgery of this
type in Mérida, Yucatán with successful results. The aim of this paper
is to do a descriptive review of the selection process, the surgical
intervention, complications, and the controversies on the use of DBS
for PD.
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