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2020, Number 4

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AMC 2020; 24 (4)

Morphometric indicators of thyroid papillary carcinoma diagnosed by escisional biopsy

Toledo-Hidalgo D, Díaz-Rojas PA

Language: Spanish
References: 22
Page: 538-548
PDF size: 517.91 Kb.


ABSTRACT

Background: thyroid is where malignant endocrine tumor diseases originate more frequently. This entity possesses multiple histological variants added to this antecedent, which are usually the cause of important diagnostic doubts. For this reason, studies in which more and more morphometric procedures are added have been developed. The success of an individualized treatment depends on an accurate diagnosis, in which morphometry is recognized by ruling out subjectivity in diagnosis, becomes a valuable tool.
Objective: morphometric characterization of papillary thyroid carcinoma diagnosed by excisional biopsies. Morphometric.
Methods: a morphometric study of a series of cases was carried out with 12 patients with this histopathological diagnosis, attended at the Vladimir Ilich Lenin University Provincial Hospital. 340 fields were selected and 10 465 cell nuclei were measured, which was our sample. Nuclear morphometric indicators were characterized, such as area, volume and shape factor.
Results: nuclear area and volume showed increased values compared to benign nodular disease values from other studies. The value of the nuclear form factor approached one, so the nuclei tend to be round and it was observed that the higher the values of the nuclear area, the higher the values of the nuclear form factor.
Conclusions: morphometric indicators of papillary thyroid carcinoma were characterized in the studied cases that may contribute to histopathological diagnosis.


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