medigraphic.com
ISSN 1727-897X (Electronic)

2020, Number 6

<< Back Next >>

Medisur 2020; 18 (6)

Using omega 3 as an anti-aging treatment

Zavala NCI

Language: Spanish
References: 45
Page: 1198-1209
PDF size: 150.69 Kb.


ABSTRACT

Aging in general, and skin aging in particular, is a deleterious and universal process. Skin aging can be divided into chronological aging and photoaging, the latter being activated through damage to human skin, attributable to repeated exposure to ultraviolet (UV) rays from sunlight. Fatty acids derived from fish oil (omega 3) have been considered to be associated with photoprotection of the skin. The objective of this work is to describe the effects of omega 3 as an anti-aging drug in the elderly population. A bibliographic review of articles published between January 2010 and June 2020, in Pubmed and Google Scholar, was carried out. The available literature shows the effect and benefit of these fatty acids in the aging process, which constitute clinical therapies at the dermatological level and in areas of plastic surgery. Its use has a positive effect on the aging process in different organs, through action against oxidative stress.


REFERENCES

  1. Porojnicu AC, Bruland OS, Aksnes L, Grant WB, Moan J. Sun beds and cod liver oil as vitamin D sources. J Photochem Photobiol B Biol. 2008;91(2-3):125-31.

  2. Loftsson T, Gudmundsdóttir TK, Fridriksdóttir H, Sigurdardóttir AM, Thorkelsson J, Gudmundsson G, y colaboradores. Fatty acids from cod-liver oil as skin penetration enhancers. Pharm. 1995;50(3):188-90.

  3. Huang TH, Wang PW, Yang SC, Chou WL, Fang JY. Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin. Mar Drugs. 2018;16(8):256.

  4. Ruiz N, Sayanova O, Napier JA, Haslam RP. Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. J Exp Bot. 2012;63(7):2397-410.

  5. Bibus D, Lands B. Balancing proportions of competing omega-3 and omega-6 highly unsaturated fatty acids (HUFA) in tissue lipids. Prostaglandins, Leukot Essent Fat Acids. 2015;99:19-23.

  6. Liu M, Yokomizo T. The role of leukotrienes in allergic diseases. Allergol Int. 2015;64(1):17-26.

  7. Breiden B, Sandhoff K. The role of sphingolipid metabolism in cutaneous permeability barrier formation. Biochim Biophys Acta - Mol Cell Biol Lipids. 2014;1841(3):441-52.

  8. Lam SM, Wang Z, Li J, Huang X, Shui G. Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox Biol. 2017;12:967-77.

  9. McCusker MM, Grant-Kels JM. Healing fats of the skin: the structural and immunologic roles of the ?-6 and ?-3 fatty acids. Clin Dermatol. 2010;28(4):440-51.

  10. Hashimoto M, Hossain S, Al Mamun A, Matsuzaki K, Arai H. Docosahexaenoic acid: one molecule diverse functions. Crit Rev Biotechnol. 2016;37(5):579-97.

  11. Lorente-Cebrián S, Costa AG V, Navas-Carretero S, Zabala M, Laiglesia LM, Martínez JA, et al. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. J Physiol Biochem. 2015;71(2):341-9.

  12. Villani AM, Crotty M, Cleland LG, James MJ, Fraser RJ, Cobiac L, y colaboradores. Fish oil administration in older adults: is there potential for adverse events? A systematic review of the literature. BMC Geriatr.2008, 13:41.

  13. de Gruijl FR. UV adaptation: Pigmentation and protection against overexposure. Exp Dermatol. 2017;26(7):557-62.

  14. Calder PC. Mechanisms of Action of (n-3) Fatty Acids. J Nutr. 2012;142(3):592S-599S.

  15. Orengo IF, Black HS, Wolf JE. Influence of fish oil supplementation on the minimal erythema dose in humans. Arch Dermatol Res. 1992;284(4):219-21.

  16. Rhodes LE, Durham BH, Fraser WD, Friedmann PS. Dietary Fish Oil Reduces Basal and Ultraviolet B-Generated PGE2 Levels in Skin and Increases the Threshold to Provocation of Polymorphic Light Eruption. J Invest Dermatol. 1995;105(4):532-5.

  17. Puglia C, Tropea S, Rizza L, Santagati NA, Bonina F. In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts. Int J Pharm. 2005;299(1-2):41-8.

  18. Molho-Pessach V, Lotem M. Ultraviolet Radiation and Cutaneous Carcinogenesis. Curr Probl Dermatol. 2013;35:14-27.

  19. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14(6):12222-48.

  20. Nikolakopoulou Z, Shaikh MH, Dehlawi H, Michael-Titus AT, Parkinson EK. The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. Toxicol Lett. 2013;218(2):150-8.

  21. Chiu LCM, Tong KF, Ooi VEC. Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. Biomed Pharmacother. 2005;59:S293-7.

  22. Elmets CA, Ledet JJ, Athar M. Cyclooxygenases: mediators of UV-induced skin cancer and potential targets for prevention. J Invest Dermatol. 2014;134(10):2497-502.

  23. Agency for Healthcare Research and Quality. Resources for Researchers [Internet]. Rockville, MD: AHTQ; 2015 [citado 19 Ago 2020]. Disponible en: http://www.ahrq.gov/research/findings/evidencebased-reports/technical/index.html.

  24. Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis. 2020;11(6):444.

  25. Anti-Aging Medicine, Vitamins, Minerals and Food Supplements: A Public Opinion Survey Conducted for the International Longevity Center. J Anti Aging Med. 2003;6(2):83-90.

  26. Kris-Etherton PM, Grieger JA, Etherton TD. Dietary reference intakes for DHA and EPA. Prostaglandins, Leukot Essent Fat Acids. 2009;81(2-3):99-104.

  27. Myriam M, Sabatier M, Steiling H, Williamson G. Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr. 2006;96(2):227-38.

  28. Doyle R, Sadlier DM, Godson C. Pro-resolving lipid mediators: Agents of anti-ageing?. Semin Immunol. 2018;40:36-48.

  29. Norling LV, Ly L, Dalli J. Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators. Curr Opin Clin Nutr Metab Care. 2017;20(2):145-52.

  30. Cho S. The Role of Functional Foods in Cutaneous Anti-aging. J lifestyle Med. 2014;4(1):8-16.

  31. Mendelsohn AR, Larrick JW. Trade-Offs Between Anti-Aging Dietary Supplementation and Exercise. Rejuvenation Res. 2013;16(5):419-26.

  32. Papanikolaou Y, Brooks J, Reider C, Fulgoni VL. Erratum to: U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. Nutr J [revista en Internet]. 2014 [citado 19 Ago 2020];13:[aprox. 2p]. Disponible en: https://nutritionj.biomedcentral.com/track/pdf/10.1186/1475-2891-13-64.pdf.

  33. Denis I, Potier B, Vancassel S, Heberden C, Lavialle M. Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms. Ageing Res Rev. 2013;12(2):579-94.

  34. Truchuelo M, Cerdá P, Fernández LF. Chemical Peeling: A Useful Tool in the Office. Actas Dermo-Sifiliográficas (English Ed). 2017;108(4):315-22.

  35. Úbeda N, Achón M, Varela-Moreiras G. Omega 3 fatty acids in the elderly. Br J Nutr. 2012;107(S2):S137-51.

  36. Chang CH, Tseng PT, Chen NY, Lin PC, Lin PY, Chang JP, et al. Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins, Leukot Essent Fat Acids. 2018;129:1-12.

  37. Harman D. Aging: A Theory Based on Free Radical and Radiation Chemistry. J Gerontol. 1956;11(3):298-300.

  38. Speakman JR, Selman C. The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan. Bioessays. 2011;33(4):255-9.

  39. Kirkwood TBL, Kowald A. The free-radical theory of ageing - older, wiser and still alive. BioEssays. 2012;34(8):692-700.

  40. da Costa JP, Vitorino R, Silva GM, Vogel C, Duarte AC, Rocha-Santos T. A synopsis on aging-Theories, mechanisms and future prospects. Ageing Res Rev. 2016;29:90-112.

  41. Laviano A, Rianda S, Molfino A, Fanelli FR. Omega-3 fatty acids in cancer. Curr Opin Clin Nutr Metab Care. 2013;16(2):156-61.

  42. Abbasoglu O, Hardy G, Manzanares W, Pontes A. Response to »,» ®,® §,§ ­,­ ¹,¹ ²,² ³,³ ß,ß Þ,Þ þ,þ ×,× Ú,Ú ú,ú Û,Û û,û Ù,Ù ù,ù ¨,¨ Ü,Ü ü,ü Ý,Ý ý,ý ¥,¥ ÿ,ÿ ¶,¶ Commentary on 'Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence' »,» ®,® §,§ ­,­ ¹,¹ ²,² ³,³ ß,ß Þ,Þ þ,þ ×,× Ú,Ú ú,ú Û,Û û,û Ù,Ù ù,ù ¨,¨ Ü,Ü ü,ü Ý,Ý ý,ý ¥,¥ ÿ,ÿ ¶,¶ . JPEN J Parenter Enteral Nutr. 2018;43(4):456-7.

  43. Bonté F, Girard D, Archambault JC, Desmoulière A. Skin Changes During Ageing. En: Harris J, Korolchuk V , editores. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry Vol. 91. Singapore: Sringer; 2019. p. 249-80.

  44. Jump DB. Fatty Acid Regulation of Gene Transcription. Crit Rev Clin Lab Sci. 2004;41(1):41-78.

  45. Goh LY, Vitry AI, Semple SJ, Esterman A, Luszcz MA. Self-medication with over-the-counter drugs and complementary medications in South Australia's elderly population. BMC Complement Altern Med. 2009;9:42.




2020     |     www.medigraphic.com