2021, Number 1
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Rev Hematol Mex 2021; 22 (1)
Prognostic clinical and serum biomarkers in diffuse large B-cell lymphoma
Aranda-Gutiérrez A, Hernández-Hernández JA, López-SánchezRC, Villela L
Language: English
References: 58
Page: 30-43
PDF size: 277.42 Kb.
ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy with significant rates
of relapse despite first-line treatment with anthracycline-based chemotherapy regimens
and rituximab. Various indexes are available to estimate survival rates in patients with
DLBCL. The most commonly employed are the International Prognostic Index (IPI),
Revised-IPI (R-IPI), and National Comprehensive Cancer Network-IPI (NCCN-IPI). However,
these indexes fail to recognize a subgroup of patients with very poor outcomes in
the rituximab era. Modern technologies have allowed for the identification of molecular
prognostic factors not contemplated in IPI, R-IPI, or NCCN-IPI that can identify patients
with dismal outcomes. However, these technologies are usually expensive, technically
challenging, and require further validation and standardization. Hence, while molecular
prognostic factors become more readily available, it is important to consider other
simpler and cheaper tools that can complement known prognostic indices. This review
will focus on prognostic laboratory biomarkers obtained at diagnosis in patients with
DLBCL treated with rituximab-containing regimens.
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