2021, Number 2
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Med Int Mex 2021; 37 (2)
Cardiovascular safety of antidiabetic drugs
González-Gálvez G, Castro-Martínez MG
Language: Spanish
References: 26
Page: 244-255
PDF size: 414.26 Kb.
ABSTRACT
Currently, any new drug for the treatment of type 2 diabetes needs cardiovascular outcome
studies to show regulators that they are safe drugs from a cardiovascular point of
view. DPP-4 inhibitors have fulfilled this requirement by demonstrating in these studies
the non-inferiority compared to placebo in the risk of cardiovascular events, showing
a neutral effect in this outcome. The GLP1 receptor agonists have shown that they are
not only safe, but they are also capable of achieving reduction in the development of
cardiovascular events and the SGLT-2 inhibitors have not only shown that they are
safe but also offer the benefit of reducing cardiovascular mortality and hospitalization
for heart failure early after its use and the potential for nephroprotection in secondary
analyzes of cardiovascular outcome studies.
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