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Colegio de Medicina Interna de México.

2021, Number 2

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Med Int Mex 2021; 37 (2)

Effect of omega 3 fatty acids as immunoregulator and reductor of complications in surgery patients

Bizueto-Monroy JL, León-Mayorga Y, González-Espinosa I, López-Gil J, Linares-Segovia B

Language: Spanish
References: 16
Page: 188-195
PDF size: 427.11 Kb.


ABSTRACT

Objective: To evaluate the effect of oral omega 3 supplementation in adults with indication of major urgent and elective surgery on the frequency of perioperative complications, incidence of systemic inflammatory response syndrome and C-reactive protein (CRP) values.
Materials and Methods: A clinical, simple random study was done with patients that were randomized between control group (without supplementation) and study group (with supplementation). The supplementation consisted of 3 g/day of omega 3 orally, from 24 hours prior to the surgical event to 72 hours after. The incidence of complications was assessed with the Clavien-Dindo scale, the systemic inflammatory response syndrome according to the ACCP/SCCM criteria and the CRP values were determined by immunoturbidimetry.
Results: There were included 101 patients. The use of omega 3 generated a lower frequency of serious postoperative complications (II-V), regardless of the type of procedure. The supplemented patients showed a tendency to present less systemic inflammatory response syndrome and their values of CRP remained stable before and after surgery. CRP values › 6.7 mg/L were associated with postoperative complications. There was a decrease in length hospital stay due to the effect of supplementation.
Conclusions: Positive quantifiable effects were identified with the oral use of omega 3 as potential immunoregulator and reductor of perioperative complications.


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