medigraphic.com
Colegio de Medicina Interna de México.

2021, Number 2

<< Back Next >>

Med Int Mex 2021; 37 (2)

Systemic lupus erythematosus in males

Mercado U, Urquiza I, Guardado JA, Araiza-Casillas R

Language: Spanish
References: 17
Page: 167-172
PDF size: 333.07 Kb.


ABSTRACT

Background: Systemic lupus erythematosus or lupus is a chronic inflammatory disease that predominantly affects women of reproductive age and only 4% to 22% of the patients are males.
Objective: To compare the clinical characteristics and outcome of lupus between male and female patients.
Materials and Methods: A comparative cross-sectional study was carried out in a second level hospital from 2010 to 2018. Men were matched 1:4 by age ± 5 years with women. For the diagnosis of lupus, the new ACR/EULAR criteria of 2019 were used, which include 7 clinical manifestations and 3 immunological criteria. The diagnosis requires 10 or more points. The disease activity and the damage index were evaluated only once by Mex-SLEDAI and the damage by SLICC/ACR.
Results: In total 127 patients were identified, from which 16 men and 64 women were included. All had 10 or more points for diagnosis and the prevalence of positive anti-DNA was 97%. Kidney disease was more likely in men at the onset of the disease (11/16 vs 19/64; p = 0.006). End-stage renal disease developed in 5/16 men and 11/64 women (p = 0.18).
Conclusions: Men with lupus had similar characteristics to those of previous articles. Men with lupus had more kidney damage than women.


REFERENCES

  1. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725. doi. 10.1002/art.1780400928.

  2. Dorner T, Furie R. Novel paradigms in systemic lupus erythematosus. Lancet 2019; 393: 2344-58. doi. 10.1016/ S0140-6736(19)30546-X.

  3. Aringer M, Costenbader KH, Daikh DI, Brinks R, et al. 2019 EULAR/ACR classification criteria for systemic lupus erythematosus. Arthitis Rheumatol 2019; 71: 1400-1412. doi. 10.1002/art.40930.

  4. Guzman J, Cardiel MH, Arce-Salinas A, Sanchez-Guerrero J, et al. Measurement of disease activity in systemic lupus erythematosus: prospective validation of 3 clinical indices. J Rheumatol 1992; 19: 1551-58.

  5. Gladman D, Ginzler E, Goldsmith C, Fortin P, et al. The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 1996; 39: 363-69. doi. 10.1002/art.1780390303.

  6. Soto ME, Vallejo M, Guillen F, Simon JA, et al. Gender impact in systemic lupus erythematosus. Clin Exp Rheumatol 2004; 22: 713-721.

  7. Molina JF, Drenkard C, Molina J, Cardiel MH, et al. Systemic lupus erythematosus in males. A study of 107 Latin American patients. Medicine 1996; 75: 124-30. doi. 10.1097/00005792-199605000-00002.

  8. García MA, Marcos JC, Marcos AI, Pons-Estel BA, et al. Male systemic lupus erythematosus in a Latin-American inception cohort of 1214 patients. Lupus 2005; 14:938-46. doi. 10.1191/0961203305lu2245oa.

  9. Muñoz-Grajales C, Gonzalez LA, Alarcon GS, Acosta-Reyes J. Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients. Lupus 2016; 0: 1-7. doi. 10.1177/0961203316635286.

  10. Shaukat F, Russinova L, Seihanova B, Rakhmetova A. Lupus nephritis; updates to current knowledge. J Nephropharmacol 2019; 8: 1-4. doi. 10.15171/npj.2019.09.

  11. Resende AL, Titan SM, Barros RT, Woronik V. Worse renal outcome of lupus nephritis in male patients: a case-control study. Lupus 2011; 20: 561-567. doi. 10.1177/0961203310392422.

  12. Shaharir SS, Abdul-Kadir WD, Nordin F, Abu-Bakar F, et al. Systemic lupus erythematosus among male patients in Malaysia: how are we different from other geographic regions. Lupus 2019; 28 (1): 137-144. doi. 10.1177/0961203318812676.

  13. Hwang J, Lee J, Kyoung JA, Park EJ, et al. Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study. Korean J Intern Med 2015; 30: 242-49. oi: 10.3904/kjim.2015.30.2.242.

  14. Lu L-J, Wallace DJ, Ishimori ML, Scofield RH, et al. Male systemic lupus erythematosus: a review of sex disparities in this disease. Lupus 2010; 19: 119-129. doi. 10.1177/0961203309350755.

  15. Scofield RH, Bruner GR, Namjou B, Kimberly RP, et al. Klinefelter’s Syndrome, 47, XXY, in male systemic lupus erythematosus supports a gene dose effect from the X chromosome. Arthritis Rheum 2008;58:2511-2517. doi. 10.1002/art.23701.

  16. Talal N. Factores inmunológicos y virales en enfermedades autoinmunitarias. Clin Med N Am 1977; 61: 205-215.

  17. Urrestarazu A, Otatti G, Silvariño R, Garau M, et al. Lupus nephritis in males: clinical features, course, and prognostic factors for end-stage renal disease. Kidney Int Rep 2017; 2: 905-912. doi. 10.1016/j.ekir.2017.05.011.




2020     |     www.medigraphic.com