2017, Number 07-08
<< Back Next >>
Medicina & Laboratorio 2017; 23 (07-08)
Hematuria in the childhood A systematic cualitative review
Paz-Montañez JJ, Mueses-Guerrero Y, Restrepo-Restrepo JM, Ortíz-Martínez RA, Acosta-Aragón MA
Language: Spanish
References: 53
Page: 351-364
PDF size: 544.33 Kb.
ABSTRACT
Introduction: Isolated hematuria in children is a frequent finding in the daily clinical practice of the general
physician and pediatrician, being a diagnostic challenge to find out its etiology and management.
Objective: To describe the basic guidelines for the diagnosis and management of isolated hematuria in
children under 18 years of age by the general physician and the pediatrician.
Materials and methods:
A systematic bibliographic search was carried out in the databases PubMed, ScienceDirect, LILACS and
Embase, using key words from DeCS (Spanish) and MeSH (English) through combinations with the conjunction
“AND” or the disjunction “ OR “, of manuscripts such as observational studies, clinical trials,
clinical practice guidelines and systematic reviews, published between 1995 and 2017 that described the
basic diagnosis and management of hematuria. The quality of the articles was evaluated through the
PRISMA, CONSORT and STROBE instruments, as was appropriate.
Results: 402 publications were identified,
of which 34 met the criteria and 28 were selected to carry out this review.
Conclusions: Isolated
hematuria is defined by the finding of five erythrocytes per high power field in centrifuged fresh urine or
more than five erythrocytes per microliter in fresh non-centrifuged urine Diagnosis and treatment are
carried out in steps: a) clinical history, and b) confirmation by high resolution optical microscopy. Differentiating
benign hematuria from those requiring paraclinical extension is essential to confirm it earlier,
avoid invasive procedures, decrease health expenditure and make predictive follow-up.
REFERENCES
Meyers KE. Evaluation of hematuria in children. Urol Clin North Am 2004; 31: 559-573.
Chung H-M, Liao Y-M, Tsai Y-C, Liu M-C. Microscopic hematuria in children. Urol Sci 2011; 22: 93-96.
Moghtaderi M, Noohi AH, Safaeyan B, Abbasi A, Sabsechian M, Meherkash M. Screening for microscopic hematuria in school-age children of Gorgan City. Iran J Kidney Dis 2014; 8: 70-72.
Lambert SM. Pediatric Urological Emergencies. Pediatr Clin 2012; 59: 965-976.
Cho BS, Hahn WH, Cheong HI, Lim I, Ko CW, Kim SY, et al. A nationwide study of mass urine screening tests on Korean school children and implications for chronic kidney disease management. Clin Exp Nephrol 2013; 17: 205-210.
Lopera-Medina MM. La enfermedad renal crónica en Colombia: necesidades en salud y respuesta del Sistema General de Seguridad Social en Salud. Gerenc Polít Salud 2016; 15: 212-233.
Hidalgo-Barquero MC, Cea-Crespo JM. Hematuria. Protoc diagn ter pediat 2014; 1: 53-68.
Kaplan BS, Pradhan M. Urinalysis interpretation for pediatricians. Pediatr Ann 2013; 42: 45-51.
Massengill SF. Hematuria. Pediatr Rev 2008; 29: 342- 348.
Tjajadi M. Ultrasonography Versus Computed Tomography for Suspected Nephrolithiasis. J Emerg Med 2014; 47: 752-753.
International Society of Nephrology. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl 2013; 3: 1-150.
Alharthi AA, Taha AA, Edrees AE, Elnawawy AN, Abdelrahman AH. Screening for urine abnormalities among preschool children in western Saudi Arabia. Saudi Med J 2014; 35: 1477-1481.
Dang LNN, Doan TLB, Doan NH, Pham TKH, Smets F, Thi MHT, et al. Epidemiological urinalysis of children from kindergartens of Can Gio, Ho Chi Minh City - Vietnam. BMC Pediatr 2013; 13: 183.
Orta N, Sanna V, Moriyón JC, de Orta S, Domínguez L, Zibaoui P, et al. Hematuria en niños: analysis of aetiology and characteristics in a national reference centre, Valencia, Venezuela. Rev Chil Pediatr 2001; 72: 92-99.
Bergstein J, Leiser J, Andreoli S. The clinical significance of asymptomatic gross and microscopic hematuria in children. Arch Pediatr Adolesc Med 2005; 159: 353-355.
Anigilaje EA, Adedoyin OT. Correlation between dipstick urinalysis and urine sediment microscopy in detecting haematuria among children with sickle cell anaemia in steady state in Ilorin, Nigeria. Pan Afr Med J 2013; 15: 1-7.
Li Z, Kang Z, Duan C, Wu T, Zhang L, Xun M, et al. Clinical and pathological features of acute kidney injury in children. Ren Fail 2014; 36: 1023-1028.
Hothan KA, Alasmari BA, Alkhelaiwi OK, Althagafi KM, Alkhaldi AA, Alfityani AK, et al. Prevalence of hypertension, obesity, hematuria and proteinuria amongst healthy adolescents living in Western Saudi Arabia. Saudi Med J 2016; 37: 1120-1126.
Yuste C, Rivera F, Moreno JA, López-Gómez JM. Haematuria on the Spanish Registry of Glomerulonephritis. Sci Rep 2016; 6: 19732.
Chen GL, Zhu J, Song MH, Ma L, Pan T, Yang Q, et al. Clinicopathologic analysis of isolated hematuria in child/ adolescent and adult patients. Pol J Pathol 2015; 66: 353- 360.
Zhai Y, Xu H, Shen Q, Cao Q, Zhu G, Wei M, et al. Renal histological features of school-age children with asymptomatic haematuria and/or proteinuria: a multicenter study. Nephrology (Carlton) 2014; 19: 426-431.
Hsieh HC, Lu PL, Chen YH, Chen TC, Tsai JJ, Chang K, et al. Genitourinary tuberculosis in a medical center in southern Taiwan: an eleven-year experience. J Microbiol Immunol Infect 2006; 39: 408-413.
Morenikeji O, Quazim J, Omoregie C, Hassan A, Nwuba R, Anumudu C, et al. A cross-sectional study on urogenital schistosomiasis in children; haematuria and proteinuria as diagnostic indicators in an endemic rural area of Nigeria. Afr Health Sci 2014; 14: 390-396.
Shima Y, Nakanishi K, Hama T, Sato M, Mukaiyama H, Togawa H, et al. Biopsy timing and Oxford classification variables in childhood/adolescent IgA nephropathy. Pediatr Nephrol 2015; 30: 293-299.
Morenikeji OA, Eleng IE, Atanda OS, Oyeyemi OT. Renal related disorders in concomitant Schistosoma haematobium- Plasmodium falciparum infection among children in a rural community of Nigeria. J Infect Public Health 2016; 9: 136-142.
Bissada NK, Safwat AS, Seyam RM, Al Sobhi S, Hanash KA, Jackson RJ, et al. Pheochromocytoma in children and adolescents: a clinical spectrum. J Pediatr Surg 2008; 43: 540-543.
Farag S, Das R, Strosnider WH, Wilson RT. Possible health effects of living in proximity to mining sites near Potosi, Bolivia. J Occup Environ Med 2015; 57: 543-551.
Yanagihara T, Hamada R, Ishikura K, Uemura O, Matsuyama T, Takahashi S, et al. Urinary screening and urinary abnormalities in 3-year-old children in Japan. Pediatr Int 2015; 57: 354-358.
Dagan R, Cleper R, Davidovits M, Sinai-Trieman L, Krause I. Post-Infectious Glomerulonephritis in Pediatric Patients over Two Decades: Severity-Associated Features. Isr Med Assoc J 2016; 18: 336-340.
Yu M-C, Lee F, Huang W-H, Hsueh S. Percutaneous ultrasound- guided renal biopsy in children: The need for renal biopsy in pediatric patients with persistent asymptomatic microscopic hematuria. Biomed J 2014; 37: 391-397.
Vivante A, Afek A, Frenkel-Nir Y, Tzur D, Farfel A, Golan E, et al. Persistent asymptomatic isolated microscopic hematuria in Israeli adolescents and young adults and risk for end-stage renal disease. JAMA 2011; 306: 729- 736.
Haysom L, Williams R, Hodson EM, Lopez-Vargas PA, Roy LP, Lyle DM, et al. Natural history of chronic kidney disease in Australian Indigenous and non-Indigenous children: a 4-year population-based follow-up study. Med J Aust 2009; 190: 303-306.
Sekhar DL, Wang L, Hollenbeak CS, Widome MD, Paul IM. A cost-effectiveness analysis of screening urine dipsticks in well-child care. Pediatrics 2010; 125.
Restrepo de Rovetto C. Hematuria en la niñez. CCAP 2002; 2: 30-40.
Marzuillo P, Guarino S, Apicella A, La Manna A, Polito C. Why we need a higher suspicion index of urolithiasis in children. J Pediatr Urol 2017; 13: 164-171.
Ingelfinger JR, Kalantar-Zadeh K, Schaefer F. Averting the legacy of kidney disease--focus on childhood. Kidney Int 2016; 89: 512-518.
Lunn A, Forbes TA. Haematuria and proteinuria in childhood. Paediatr Child Heal (United Kingdom) 2012; 22: 315-321.
Feng CY, Xia YH, Wang WJ, Xia J, Fu HD, Wang X, et al. Persistent asymptomatic isolated hematuria in children: clinical and histopathological features and prognosis. World J Pediatr 2013; 9: 163-168.
Chan MM, Gale DP. Isolated microscopic haematuria of glomerular origin: clinical significance and diagnosis in the 21st century. Clin Med (Lond) 2015; 15: 576-580.
Feld LG, Waz WR, Perez LM, Joseph DB. Hematuria. An integrated medical and surgical approach. Pediatr Clin North Am 1997; 44: 1191-1210.
Jiang D, Geng H. Primary Hyperoxaluria. New Engl J Med 2017; 376: e33.
Cruz AT, Starke JR. Clinical manifestations of tuberculosis in children. Paediatr Respir Rev 2007; 8: 107-117.
Mayans AF, Feu OA, Til HA, Terroba YA, Fernández RB, Tur AB, et al. Renal Tuberculosis in a 9 Months Old: Case Report and Review of the Literature. Urol Case Rep 2017; 13: 104-106.
Velásquez-Forero F, Esparza M, Salas A, Medeiros M, Toussaint G, Llach F. Risk factors evaluation for urolithiasis among children. Bol Med Hosp Infant Mex 2016; 73: 228-236.
Abou-Elela A. Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review. J Adv Res 2017; 8: 513-527.
Goldenberg NA, Bernard TJ. Venous thromboembolism in children. Pediatr Clin North Am 2008; 55: 305-322, vii.
Utsch B, Klaus G. Urinalysis in children and adolescents. Dtsch Arztebl Int 2014; 111: 617-625; quiz 626.
Cohen RA, Brown RS. Clinical practice. Microscopic hematuria. N Engl J Med 2003; 348: 2330-2338.
Sinha CK, Lander A. Trauma in children: abdomen and thorax. Surg 2013; 31: 123-129.
Tanaka ST, Brock JW, 3rd. Pediatric urologic conditions, including urinary infections. Med Clin North Am 2011; 95: 1-13.
Vila Cots J, Giménez Llort A, Camacho Díaz JA, Vila Santandreu A. Nefropatía en la púrpura de Schönlein- Henoch: estudio retrospectivo de los últimos 25 años. An Pediatr (Barc) 2007; 66: 290-293.
Cho BS, Kim SD. School urinalysis screening in Korea. Nephrology (Carlton) 2007; 12.
Raab CP, Gartner JC, Jr. Diagnosis of childhood cancer. Prim Care 2009; 36: 671-684.