medigraphic.com
ISSN 2500-7106 (Electronic)
ISSN 0123-2576 (Print)
Medicina & Laboratorio

2020, Number 4

<< Back Next >>

Medicina & Laboratorio 2020; 24 (4)

Celiac disease and the development of secondary disorders

Solano-Sánchez D, Quesada-Yamasaki DA

Language: Spanish
References: 56
Page: 291-305
PDF size: 507.75 Kb.


ABSTRACT

Celiac disease is a systemic autoimmune pathology characterized by a chronic inflammatory state of the intestinal mucosa and submucosa, of multifactorial origin and triggered by environmental factors such as gluten intake in individuals genetically predisposed to become sensitized to such protein. The worldwide prevalence of the disease is estimated to be between 1.1% and 1.7%, based on seroprevalence data. However, it is considered that there are a significant number of undiagnosed individuals, who could develop a series of complications due to not receiving adequate management. For this reason, the objective of this review is to assess some of the most frequent secondary disorders associated with celiac disease, evidencing the systemic involvement that an individual with this disease can develop.


REFERENCES

  1. Organización Mundial de la Salud. Clasificación internacional de enfermedades para estadísticas de mortalidad y morbilidad. 11a revisión. DA 95-Enfermedad celíaca. Ginebra: OMS; 2019. Acceso 15 de mayo de 2020. Disponible en https://icd.who.int/browse11/l-m/ es#/http://id.who.int/icd/entity/2005943638.

  2. Salazar C, García-Cárdenas JM, Paz y-Miño C. Understanding celiac disease from genetics to the future diagnostic strategies. Clin Med Insights Gastroenterol 2017;10: 80502508. https://doi.org/10.1177/1179552217712249.

  3. Dieli-Crimi R, Cénit MC, Núñez C. The genetics of celiac disease: A comprehensive review of clinical implications. J Autoimmun 2015;64:26-41. https://doi.org/https://doi. org/10.1016/j.jaut.2015.07.003.

  4. Parzanese I, Qehajaj D, Patrinicola F, Aralica M, Chiriva-Internati M, Stifter S, et al. Celiac disease: From pathophysiology to treatment. World J Gastrointest Pathophysiol 2017;8:27- 38. https://doi.org/10.4291/wjgp.v8.i2.27.

  5. Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, et al. Global prevalence of celiac disease: Systematic review and meta-analysis. Clin Gastroenterol Hepatol 2018;16:823-836.e822. https://doi.org/10.1016/j.cgh.2017.06.037.

  6. West J, Fleming KM, Tata LJ, Card TR, Crooks CJ. Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol 2014;109:757-768. https://doi. org/10.1038/ajg.2014.55.

  7. Altobelli E, Paduano R, Petrocelli R, Di Orio F. Burden of celiac disease in Europe: a review of its childhood and adulthood prevalence and incidence as of September 2014. Ann Ig 2014;26:485-498. https://doi.org/10.7416/ ai.2014.2007.

  8. Lerner A, Lopez F, Schmiedl A, Matthias T. The underdiagnosed enemy: Africa goes celiac? Int J Celiac Dis 2019;7:9-12.

  9. Jabeen. Celiac disease. From the bench to the clinic. In: Rodrigo L, Hernández-Lahoz C, eds. Complications of Celiac Disease. Londres: IntechOpen; 2019. p. 20. https://doi.org/https:// doi.org/10.5772/intechopen.80465.

  10. Stier K, Lewis SK, Bhagat G, Green PHR. Research publication trends regarding the extraintestinal manifestations of celiac disease. Inform Med Unlocked 2019;17:100242. https://doi.org/ https://doi.org/10.1016/j.imu.2019.100242.

  11. Valderas JM, Starfield B, Sibbald B, Salisbury C, Roland M. Defining comorbidity: implications for understanding health and health services. Ann Fam Med 2009;7:357-363. https://doi. org/10.1370/afm.983.

  12. Laurikka P, Nurminen S, Kivelä L, Kurppa K. Extraintestinal manifestations of celiac disease: Early detection for better long-term outcomes. Nutrients 2018;10:1015. https://doi. org/10.3390/nu10081015.

  13. Bartl R, Bartl C. Definition of Osteoporosis. In: Bartl R, Bartl C, eds. Bone Disorders. Suiza: Sprin- ger, Cham; 2016. p. 109-110. https://doi.org/ https://doi.org/10.1007/978-3-319-29182-6.

  14. Brunetto OH. Osteoporosis en pediatría. Rev Argent Endocrinol Metab 2006;43:90-108.

  15. Jódar-Gimeno E. Osteoporosis secundarias. Medicine 2014;11:3535-3544. https://doi. org/10.1016/S0304-5412(14)70812-1.

  16. Zanini B, Baschè R, Ferraresi A, Pigozzi MG, Ricci C, Lanzarotto F, et al. Factors that contribute to hypertransaminasemia in patients with celiac disease or functional gastrointestinal syndromes. Clin Gastroenterol Hepatol 2014;12:804-810.e802. https://doi. org/10.1016/j.cgh.2013.10.033.

  17. Hatanaka SA, Silva N, Dantas-Correa E, Schiavon L, Narciso-Schiavon J. The effect of a gluten-free diet on alanine aminotransferase (ALT) in celiac patients. Rev Colomb Gastroenterol 2015;30:412-418.

  18. Cantarero-Vallejo MD, Gómez-Camarero J, Menchén L, Pajares-Díaz JA, Lo Iacono O. Daño hepático y enfermedad celíaca. Rev Esp Enferm Dig 2007;99:648-652.

  19. Barbero-Villares A, Moreno-Monteagudo JA, Moreno-Borque R, Moreno-Otero R. Afectación hepática en la enfermedad celíaca. Gastroenterol Hepatol 2008;31:25-28. https://doi. org/10.1157/13114567.

  20. Alonso-Cotoner C, Casellas-Jordá F, Chicharro- Serrano ML, Torres-Ramírez Id, Malagelada- Benaprés JR. Ferropenia: no siempre son pérdidas. An Med Interna 2003;20:11-15.

  21. Mearin F, Balboa A, Castells A, Domínguez JE, Esteve M, García-Erce JA, et al. Anemia ferropénica y uso de hierro endovenoso en patología digestiva. Gastroenterol Hepatol 2010;33:605-613. https://doi.org/10.1016/j.gastrohep. 2010.08.001.

  22. Kumar V, Parmeshwarappa S, Vadde A. Celiac disease manifesting as isolated cobalamin deficiency megaloblastic anemia: Case series and review. J Sci Soc 2014;41:211-214. https:// doi.org/10.4103/0974-5009.141246.

  23. Berry N, Basha J, Varma N, Varma S, Prasad KK, Vaiphei K, et al. Anemia in celiac disease is multifactorial in etiology: A prospective study from India. JGH Open 2018;2:196-200. https:// doi.org/10.1002/jgh3.12073.

  24. Sanjinés L, Martínez M, Magliano J. Dermatitis herpetiforme como carta de presentación de la enfermedad celíaca. Rev Urug Med Int 2016;1:3.

  25. Fonseca E. Manifestaciones cutáneas en la enfermedad celiaca. Pediatrika 2003;23:38-39.

  26. Işıkay S, Kocamaz H, Sezer S, Özkars MY, Işıkay N, Filik B, et al. The frequency of epileptiform discharges in celiac disease. Pediatr Neurol 2015;53:78-82. https://doi.org/10.1016/j. pediatrneurol.2015.02.006.

  27. Croall ID, Sanders DS, Hadjivassiliou M, Hoggard N. Cognitive deficit and white matter changes in persons with celiac disease: A population-based study. Gastroenterology 2020;158:2112-2122. https://doi. org/10.1053/j.gastro.2020.02.028.

  28. Bledsoe AC, King KS, Larson JJ, Snyder M, Absah I, Choung RS, et al. Micronutrient deficiencies are common in contemporary celiac disease despite lack of overt malabsorption symptoms. Mayo Clin Proc 2019;94:1253-1260. https://doi. org/10.1016/j.mayocp.2018.11.036.

  29. Maxwell PJ, Montgomery SC, Cavallazzi R, Martindale RG. What micronutrient deficiencies should be considered in distinct neurological disorders? Curr Gastroenterol Rep 2013;15:331. https://doi.org/10.1007/s11894- 013-0331-7.

  30. Henri-Bhargava A, Melmed C, Glikstein R, Schipper HM. Neurologic impairment due to vitamin e and copper deficiencies in celiac disease. Neurology 2008;71:860-861. https://doi. org/10.1212/01.wnl.0000325473.13088.18.

  31. Avila JD, Lacomis D. Proximal limb weakness in a patient with celiac disease: Copper deficiency, gluten sensitivity, or both as the underlying cause? Case Rep Neurol Med 2016;2016:5415949. https://doi.org/10.1155/2016/5415949.

  32. Di Nardo G, Villa MP, Conti L, Ranucci G, Pacchiarotti C, Principessa L, et al. Nutritional deficiencies in children with celiac disease resulting from a gluten-free diet: A systematic review. Nutrients 2019;11:1588. https://doi. org/10.3390/nu11071588.

  33. Hadjivassiliou M, Croall ID, Zis P, Sarrigiannis PG, Sanders DS, Aeschlimann P, et al. Neurologic deficits in patients with newly diagnosed celiac disease are frequent and linked with autoimmunity to transglutaminase 6. J Clin Gastroenterol Hepatol 2019;17:2678-2686.e2672. https://doi.org/10.1016/j.cgh.2019.03.014.

  34. Stamnaes J, Dorum S, Fleckenstein B, Aeschlimann D, Sollid LM. Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia. Amino Acids 2010;39:1183-1191. https://doi. org/10.1007/s00726-010-0554-y.

  35. Yu XB, Uhde M, Green PH, Alaedini A. Autoantibodies in the extraintestinal manifestations of celiac disease. Nutrients 2018;10:1123. https://doi.org/10.3390/nu10081123.

  36. Alaedini A, Latov N. Transglutaminase-independent binding of gliadin to intestinal brush border membrane and GM1 ganglioside. J Neuroimmunol 2006;177:167-172. https://doi. org/10.1016/j.jneuroim.2006.04.022.

  37. Volta U, De Giorgio R, Granito A, Stanghellini V, Barbara G, Avoni P, et al. Anti-ganglioside antibodies in coeliac disease with neurological disorders. Dig Liver Dis 2006;38:183-187. https://doi.org/10.1016/j.dld.2005.11.013.

  38. Alaedini A, Okamoto H, Briani C, Wollenberg K, Shill HA, Bushara KO, et al. Immune crossreactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I. J Immunol 2007;178:6590-6595. https://doi.org/10.4049/ jimmunol.178.10.6590.

  39. Ferlazzo E, Polidoro S, Gobbi G, Gasparini S, Sueri C, Cianci V, et al. Epilepsy, cerebral calcifications, and gluten-related disorders: Are anti-transglutaminase 6 antibodies the missing link? Seizure 2019;73:17-20. https://doi. org/10.1016/j.seizure.2019.10.012.

  40. Briani C, Zara G, Alaedini A, Grassivaro F, Ruggero S, Toffanin E, et al. Neurological complications of celiac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol 2008;195:171-175. https://doi. org/10.1016/j.jneuroim.2008.01.008.

  41. Real RE, Valenzuela JA, González NR. Enfermedad celiaca silente en pacientes adultos con enfermedades tiroideas autoinmunes. An Fac Cienc Méd 2020;53:71-80. https:// doi.org/http://dx.doi.org/10.18004/anales/ 2020.053.01.71-080.

  42. Navarro G. Enfermedad celiaca e infertilidad no explicada: papel del tamizaje. Revisión de literatura. Rev Cien Sal Int Con 2020;4:115-122 https:// doi.org/10.34192/cienciaysalud.v4i3.153.

  43. Ramírez-Benítez AI, Miranda-Ojeda MC, Ferreira L, Palacios-Lugo MC, Jiménez-González JT. Enfermedad celiaca y diabetes mellitus tipo 1: asociación y características clínicas. Rev virtual Soc Parag Med Int 2014;1:8-17.

  44. Mearin ML. The prevention of coeliac disease. Best Pract Res Clin Gastroenterol 2015;29:493- 501. https://doi.org/10.1016/j.bpg.2015.04.003.

  45. Rose C, Armbruster FP, Ruppert J, Igl BW, Zillikens D, Shimanovich I. Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet. J Am Acad Dermatol 2009;61:39-43. https://doi. org/10.1016/j.jaad.2008.12.037.

  46. Borroni G, Biagi F, Ciocca O, Vassallo C, Carugno A, Cananzi R, et al. IgA anti-epidermal transglutaminase autoantibodies: a sensible and sensitive marker for diagnosis of dermatitis herpetiformis in adult patients. J Eur Acad Dermatol Venereol 2013;27:836-841. https://doi. org/10.1111/j.1468-3083.2012.04586.x.

  47. Larussa T, Suraci E, Nazionale I, Abenavoli L, Imeneo M, Luzza F. Bone mineralization in celiac disease. Gastroenterol Res Pract 2012;2012:198025. https://doi. org/10.1155/2012/198025.

  48. Powers JM, O’Brien SH. How I approach iron deficiency with and without anemia. Pediatr Blood Cancer 2019;66:e27544. https://doi. org/10.1002/pbc.27544.

  49. Heaney RP. Phosphorus nutrition and the treatment of osteoporosis. Mayo Clin Proc 2004;79:91-97. https://doi.org/10.4065/79.1.91.

  50. Saadati N, Khodashahi M, Naghibzadeh B, Adibi E. Osteomalacia with looser zones caused by celiac disease. Rheumatol Res 2017;2:109-112. https://doi.org/10.22631/rr.2017.69997.1027.

  51. Patel SR, Shashaty RJ, Denoux P. Nutritional nightmare: Hypoparathyroidism secondary to celiac disease. Am J Med 2017;130:e525. https://doi.org/10.1016/j.amjmed.2017.07.032.

  52. Ludvigsson JF, Kämpe O, Lebwohl B, Green PH, Silverberg SJ, Ekbom A. Primary hyperpa rathyroidism and celiac disease: a populationbased cohort study. J Clin Endocrinol Metab 2012;97:897-904. https://doi.org/10.1210/ jc.2011-2639.

  53. Fouda MA, Khan AA, Sultan MS, Rios LP, McAssey K, Armstrong D. Evaluation and management of skeletal health in celiac disease: position statement. Can J Gastroenterol 2012;26:819- 829. https://doi.org/10.1155/2012/823648.

  54. Wierdsma NJ, van Bokhorst-de van der Schueren MAE, Berkenpas M, Mulder CJJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 2013;5:3975- 3992. https://doi.org/10.3390/nu5103975.

  55. Elliott C. The nutritional quality of gluten- free products for children. Pediatrics 2018;142:e20180525. https://doi.org/10.1542/ peds.2018-0525.

  56. Larretxi I, Txurruka I, Navarro V, Lasa A, Bustamante M, Fernández-Gil MDP, et al. Micronutrient analysis of gluten-free products: Their low content is not involved in gluten-free diet imbalance in a cohort of celiac children and adolescent. Foods 2019;8:321. https://doi. org/10.3390/foods8080321.




2020     |     www.medigraphic.com