2019, Number 6
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Rev Med Inst Mex Seguro Soc 2019; 57 (6)
Allergies as a target of interest in the era of immunotherapy
Gutiérrez-de Anda KV, Juárez-Martínez LA, Juárez-Avendaño G, Pelayo R, Balandrán JC
Language: Spanish
References: 36
Page: 379-386
PDF size: 217.01 Kb.
ABSTRACT
Exacerbated immune system reactions often trigger
allergy pathologies, which include asthma, rhinitis,
urticaria, food and drug allergies, insect bites, and may
sometimes have fatal outcomes. In Mexico, more than
20% of open population, present allergic symptoms with
notable increase in the last twenty years, especially in
children. The Mexican Institute for Social Security
(IMSS, according to its initials in Spanish) provides
attention to around 7000 patients per year, mainly due to
allergies deriving from therapeutic drugs and certain
foods. Pharmacotherapy has been effective in reducing
classical allergy symptoms, although treatment does not
stop disease progression. In addition, the constant use
of drugs represents a remarkable socioeconomic impact.
Strategies based on the modification of immune
responses in the course of allergic reactions through
immunotherapy started more than 100 years ago, and
some have provided cure to the disease. On the
occasion of the Nobel Prize in Physiology or Medicine
2018, it was awarded to James P. Allison and Tasuku
Honjo for their contributions in the regulation of the
immune system against cancer, through a new
generation of immunotherapy. In this review we
analyzed current immunotherapeutic options, including
its benefits, limitations and perspectives for the best
clinical management of allergies.
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