Álvarez-Rangel LE, Martínez-Guillén P, Granados-Ventura L, Cuamba-Nambo I, Pérez-López MJ, Chávez-López EL, Aguilar-Martínez C

Language: Spanish
References: 30
Page: 348-356
PDF size: 217.51 Kb.

ABSTRACT

Background: Kidney transplantation is the therapy of choice for patients with chronic renal failure. In Mexico, good short-term results have been reported for graft survival, which is why it was carried out a study in a third level center in Mexico City to broaden these results.
Objective: To identify long-term results of patient and graft survival.
Material and methods: Retrospective study with first 1600 kidney transplants performed at the Hospital de Especialidades (Specialties Hospital) “Dr. Antonio Fraga Mouret” from La Raza National Medical Center. Patient and graft survival was analyzed at 1, 3, 5, 7 and 10 years. Kaplan-Meier survival analysis and log-rank test were performed.
Results: Between October 1979 and May 2015, 1600 kidney transplants were performed (1473 [92.1%] of living donor and 127 [7.9%] of deceased donor). Graft survival censored for death with functional graft at 1, 3, 5, 7 and 10 years was 95.4, 91.7, 88.2, 86.6 and 85.5%, respectively. Patient survival was 92.7, 90.4, 89.7, 89.4, and 88.9% at 1, 3, 5, 7 and 10 years, respectively.
Conclusions: Long-term patient and graft survival in our center is similar to that reported by other centers at an international level.

REFERENCES

1. Maglakelidze N, Pantsulaia T, Tchokhonelidze I, Managadze L, Chkhotua A. Assessment of healthrelated quality of life in renal transplant recipients and dialysis patients. Transplant Proc. 2011;43(1):376-9.

2. Liem YS, Bosch JL, Hunink MG. Preferencebased quality of life of patients on renal replacement therapy: a systematic review and meta-analysis. Value Health 2008;11(4):733-41.

3. Ogutmen B, Yildirim A, Sever MS, Bozfakioglu S, Ataman R, Erek E, et al. Health-related quality of life after kidney transplantation in comparison intermittent hemodialysis, peritoneal dialysis, and normal controls. Transplant Proc. 2006;38(2):419-21.

4. Fujisawa M, Ichikawa Y, Yoshiya K, Isotani S, Higuchi A, Nagano S, et al. Assessment of healthrelated quality of life in renal transplant and hemodialysis patients using the SF-36 health survey. Urology. 2000;56 (2):201-6.

5. Alvares J, Cesar CC, Acurcio Fde A, Andrade EI, Cherchiglia ML. Quality of life of patients in renal replacement therapy in Brazil: comparison of treatment modalities. Qual Life Res . 2012;21(6):983-91.

6. Liem YS, Bosch JL, Arends LR, Heijenbrok-Kal MH, Hunink MG. Quality of life assessed with the Medical Outcomes Study Short Form 36-Item Health Survey of patients on renal replacement therapy: a systematic review and metaanalysis. Value Health. 2007;10(5):390-7.

7. Tonelli M, Wiebe N, Knoll G, Bello A, Browne S, Jadhav D, et al. Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant. 2011;11(10):2093-109.

8. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LYC, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341(23):1725-30.

9. Ojo AO, Hanson JA, Meier-Kriesche HU, Okechukwu CN, Wolfe RA, Leichtman AB, et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol. 2001;12(3):589-97.

10. Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Schnitzler MA, et al. OPTN/SRTR 2012 Annual Data Report: Kidney. Am J Transplantation. 2014; 14 (Suppl 1): 11-44.

11. Heidelberg University. Institute of Immunology. Collaborative Transplant Study website. Heidelberg University; Last Update: May 01, 2020. Disponible en http://www.ctstransplant. org

12. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med. 2000;342:605-12.

13. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: current concepts and future directions. Transplantation. 2006;81:643-54.

14. Toma H, Tanabe K, Tokumoto T, Shimizu T, Shimmura H. Time-dependent risk factors influencing the long-term outcome in living renal allografts: donor age is crucial risk factor for long-term graft survival more than 5 years after transplantation. Transplantation. 2001;72:940-7.

15. Pieringer H, Biesenbach G. Risk factors for delayed kidney function and impact of delayed function on patient and graft survival in adult graft recipients. Clin Transplant. 2005;19:391-8.

16. Kaplan B. Overcoming Barries to Long-Term Graft Survival. Am J Kidney Dis. 2006;47:S52-64.

17. Dib-Kuri A, Bordes-Aznar J, Alberu J, Diliz H, Wolpert E. Transplantation in Mexico. Transplant Proc. 1992;24:1796-7.

18. Bordes-Aznar J, Peña JC, Herrera-Acosta J, Tamayo J, Elias-Dib J, Gabilondo F, et al. Twenty-four-year experience in kidney transplantation at one single institution in Mexico City. Transplant Proc. 1992;24:1794-5.

19. Melchor JL, Gracida C, López A, Sanmartin MA, Ibarra A, Cancino J, et al. Kidney transplantation in Mexico. Clin Transpl. 2000:379-80. Med Inst Mex Seguro Soc. 2019;57(6):348-56 􀀁

20. Monteón FJ, Gómez B, Valdespino C, Chávez S, Sandoval M, Flores A, et al. The kidney transplant experience at Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara México. Clin Transpl. 2003:165-74.

21. Álvarez-Rangel LE, Guerra-Briones BI, Cortés-Paz E, Cruz-Santiago J, Medina-Uicab C, Cardona-Chávez JG et al. Supervivencia de Paciente e Injerto al Año de Trasplante Renal de Donante Vivo: Resultados del Hospital de Especialidades “Dr. Antonio Fraga Mouret” del Centro Médico Nacional La Raza. Nefrología Mexicana 2009;30:7-13.

22. Ticona-Garrón AB, Álvarez-Rangel LE, Jiménez- Domínguez A, Cruz-Santiago J, Medina-Uicab C, Meza- Jiménez G et al. Supervivencia del paciente e injerto al año de trasplante de donante vivo Rev Mex Urol. 2010; 70:347-53.

23. Álvarez-Rangel LE, Cruz-Santiago J, Meza-Jiménez G, Bernáldez-Gómez G, Ledesma-González VM, Camacho- Hernández F et al. Modificación de la calidad de vida relacionada con la salud en receptores de trasplante renal. Rev Med Inst Mex Seguro Soc. 2015;53(Suppl 1):S66-73.

24. Marino-Vázquez LA, Sánchez-Ugarte R, Morales- Buenrostro LE. Trasplante renal: primeros mil trasplantes en el Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, en la Ciudad de México. Rev Invest Clin. 2011;63(Suppl 1):6-13.

25. Mancilla-Urrea E, Aburto-Morales S, Kasep-Bahena J, Rodríguez-Castellanos F. Programa de trasplante renal en el Instituto Nacional de Cardiología Ignacio Chávez. Rev Invest Clin. 2011;63(Suppl 1):14-8.

26. Gracida-Juárez C, Espinoza-Pérez R, Cancino-López JD, Ibarra-Villanueva A, Cedillo-López U, Villegas-Anzo F et al. Experiencia en trasplante renal en el Hospital de Especialidades Bernardo Sepúlveda del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS). Rev Invest Clin. 2011;63(Suppl 1):19-24.

27. Arellano-Torres EM, Guerrero-González E, Sánchez- Ramírez H, Pérez-Ramírez JL, Sánchez-Martínez C, Martínez-Jiménez JG et al. Trasplante Renal. Experiencia en el Hospital Universitario José E. González, UANL, en Monterrey, México. Rev Invest Clin. 2011;63(Suppl 1):25-9.

28. Reyes-Acevedo R, Romo-Franco L, Delgadillo-Castañeda R, Orozco-Lozano I, Melchor-Romo M, Gil-Guzmán E et al. Programa de trasplante renal del centenario Hospital Miguel Hidalgo en Aguascalientes, México. Rev Invest Clin. 2011;63(Suppl 1):30-7.

29. Juárez-De la Cruz FJ, Barrios-Reyes CY, Cano-López de Nava L, Adalid-Sainz C. Programa de trasplante multiorgánico en el Hospital de Especialidades 71, Unidad Médica de Alta Especialidad 134 del Instituto Mexicano del Seguro Social en Torreón. Rev Invest Clin. 2011;63(Suppl 1):50-6.

30. Medeiros-Domingo M, Romero-Navarro B, Valverde-Rosas S, Delgadillo R, Varela-Fascinetto G, Muñoz-Arizpe R. Trasplante renal en pediatría. Rev Invest Clin. 2005;57: 230-6.