Bobadilla SL, Gutiérrez SBJ, Portela OJM, García HLA, Cendejas SA, Mendoza RJJ, Garza BG

Language: Spanish
References: 18
Page: 89-91
PDF size: 179.13 Kb.

ABSTRACT

Introduction: There have been promising results for decreasing the incidence and intensity of postoperative sore throat with the use of sprayed benzydamine or intracuff alkalinized lidocaine. At the time of our review, there were no reports that found a superior outcome of their use either alone or as adjuncts. Material and methods: We conducted a triple blinded randomized controlled trial composed of four groups: control (placebo-placebo), lidocaine-benzydamine, placebo-benzydamine, lidocaine-placebo with 18 patients randomly allocated to each group. We recorded NAS (numerical analog scale) at 15 min, 1 h, 3 h, 12 h, and 24 h for each group as well as other variables of interest. Results: We analyzed the data from 72 patients and detected a statistically significant difference in the intensity of sore throat during the first 24 hours in favor of one group (lidocaine-placebo with a p = 0.003). Conclusion: Intracuff alkalinized lidocaine is more effective in decreasing the incidence and intensity of postoperative sore throat compared to the use of benzydamine alone or as an adjunct to alkalinized lidocaine.

REFERENCES

1. Huang YS, Hung NK, Lee MS, Kuo CP, Yu JC, Huang GS et al. The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat. Anesth Analg. 2010; 111 (4): 887-891.

2. Navarro LH, Lima RM, Aguiar AS, Braz JR, Carness JM, Módolo NS. The effect of intracuff alkalinized 2% lidocaine on emergence coughing, sore throat, and hoarseness in smokers. Rev Assoc Med Bras (1992). 2012; 58 (2): 248-253.

3. McHardy FE, Chung F. Postoperative sore throat: cause, prevention and treatment. Anaesthesia. 1999; 54 (5): 444-453.

4. Lam F, Lin YC, Tsai HC, Chen TL, Tam KW, Chen CY. Effect of intracuff lidocaine on postoperative sore throat and the emergence phenomenon: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2015; 10 (8): e0136184.

5. Estebe JP, Gentili M, Le Corre P, Dollo G, Chevanne F, Ecoffey C. Alkalinization of intracuff lidocaine: efficacy and safety. Anesth Analg. 2005; 101 (5): 1536-1541.

6. D'Aragon F, Beaudet N, Gagnon V, Martin R, Sansoucy Y. The effects of lidocaine spray and intracuff alkalinized lidocaine on the occurrence of cough at extubation: a double-blind randomized controlled trial. Can J Anaesth. 2013; 60 (4): 370-376.

7. Hung NK, Wu CT, Chan SM, Lu CH, Huang YS, Yeh CC et al. Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. Anesth Analg. 2010; 111 (4): 882-886.

8. Jaensson M, Gupta A, Nilsson UG. Risk factors for development of postoperative sore throat and hoarseness after endotracheal intubation in women: a secondary analysis. AANA J. 2012; 80 (4 Suppl): S67-S73.

9. Biro P, Seifert B, Pasch T. Complaints of sore throat after tracheal intubation: a prospective evaluation. Eur J Anaesthesiol. 2005; 22 (4): 307-311.

10. Chang JE, Min SW, Kim CS, Han SH, Kwon YS, Hwang JY. Effect of prophylactic benzydamine hydrochloride on postoperative sore throat and hoarseness after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled trial. Can J Anaesth. 2015; 62 (10): 1097-1103.

11. Jaensson M, Gupta A, Nilsson U. Gender differences in sore throat and hoarseness following endotracheal tube or laryngeal mask airway: a prospective study. BMC Anesthesiol. 2014; 14: 56.

12. El-Boghdadly K, Bailey CR, Wiles MD. Postoperative sore throat: a systematic review. Anaesthesia. 2016; 71 (6): 706-717.

13. Estebe JP, Delahaye S, Le Corre P, Dollo G, Le Naoures A, Chevanne F et al. Alkalinization of intra-cuff lidocaine and use of gel lubrication protect against tracheal tube-induced emergence phenomena. Br J Anaesth. 2004; 92 (3): 361-366.

14. Huang CJ, Tsai MC, Chen CT, Cheng CR, Wu KH, Wei TT. In vitro diffusion of lidocaine across endotracheal tube cuffs. Can J Anaesth. 1999; 46 (1): 82-86.

15. Navarro LH, Braz JR, Nakamura G, Lima RM, Silva Fde P, Módolo NS. Effectiveness and safety of endotracheal tube cuffs filled with air versus filled with alkalinized lidocaine: a randomized clinical trial. Sao Paulo Med J. 2007; 125 (6): 322-328.

16. Aqil M, Khan MU, Mansoor S, Mansoor S, Khokhar RS, Narejo AS. Incidence and severity of postoperative sore throat: a randomized comparison of Glidescope with Macintosh laryngoscope. BMC Anesthesiol. 2017; 17 (1): 127.

17. Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg. 1999; 89 (3): 652-658.

18. Wilson ME, Apiegelhalter D, Robertson JA et al. Predicting difficult intubation. Br J Anesth. 1988; 61: 211-216.