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2020, Number 4

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Rev Educ Bioquimica 2020; 39 (4)

Muerte o supervivencia: el controvertido papel de las dietas cetogénicas y su uso como adyuvante en el tratamiento contra el cáncer

León-Martínez M, Calderón-Salinas JV

Language: Spanish
References: 71
Page: 108-120
PDF size: 433.22 Kb.


ABSTRACT

In this work, preclinical supporting data show that ketogenic therapy through ketogenic diets can be adjunct in order to improve the ionizing radiation treatment. The first effect relates to the metabolic shift reducing glycolysis and enhancing mitochondrial metabolism, which selective increases reactive oxygen species (EROS) production and reduce adenosine triphosphate (ATP) production in neoplastic cells. The second effect is based on the differential stress resistance phenomenon describing the reprogramming of tumor cells, from proliferation towards maintenance and stress resistance of normal cells when glucose, insulin and growth factor are reduce and these causes a decrease angiogenic and metastatic efficiency of cancer cells, meanwhile ketone body levels are elevated the non-cancer cells can survive, nevertheless it contrast with patient condition and side effects.


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