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Federación Mexicana de Ginecología y Obstetricia, A.C.

2021, Number 02

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Ginecol Obstet Mex 2021; 89 (02)

Omentin-1 in gestational diabetes and its relationship to the inflammatory process

Peña-Cano MI, Saucedo R, Valencia J, González-Reynoso R, Luis-López ER, Díaz-Velázquez MF

Language: Spanish
References: 33
Page: 100-108
PDF size: 214.76 Kb.


ABSTRACT

Objective: To determine the serum concentration of omentin-1 in patients with gestational diabetes mellitus and to establish its relationship with the inflammatory process, evaluated through the measurement of PCR, MCP-1 and TNF-alpha.
Material and Method: Transversal, comparative study, with non-probabilistic sampling for convenience, carried out between January and December 2019 in patients with gestational diabetes mellitus and healthy pregnant women attended for elective cesarean section in the Hospital de Ginecología y Obstetricia 3, Centro Médico La Raza, IMSS and in the Hospital de Ginecología y Obstetricia 221, IMSS, Toluca, Estado de México. All of them had a blood sample taken at the end of the pregnancy to quantify the concentrations of adipocin omentin-1 and inflammatory molecules.
Results: Thirty-eight patients with gestational diabetes and 38 without were studied. Serum levels of omentin-1 were lower in patients with gestational diabetes mellitus compared with those of the control group [median (interquartile range), 449.6 ng/ mL (384.4-502.3) vs 573.8 ng/mL (439.3-639.2), p = 0.002]. Likewise, they inversely related with MCP-1 (r = -0.317, p = 0.017) and TNF-alpha (r = -0.280, p = 0.037); however, there was no relation with CRP (r = -0.071, p = 0.602). In multivariate analysis, the predictor factor for omentin-1 was the BMI at the end of gestation (beta = -0.318, p = 0.021).
Conclusion In patients with gestational diabetes mellitus, omentin-1 concentrations were lower compared to healthy pregnant women, which was negatively related to inflammatory molecules. The body mass index at the end of the pregnancy influenced these observations.


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