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Instituto Nacional de Salud Pública

2021, Number 1

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salud publica mex 2021; 63 (1)

Demographic and clinical factors associated with dengue mortality in Colombia: a case-control study

Pimentel J, Zuluaga G, Borrero E, Andersson N

Language: Spanish
References: 39
Page: 42-50
PDF size: 307.91 Kb.


ABSTRACT

Objective. To identify demographic and clinical factors associated with mortality due to severe dengue in five departments in Colombia. Materials and methods. Case-control study with patients admitted between 2009 and 2013. The cases were patients who died from dengue and the controls where patients with severe dengue who survived the disease. A multivariate analysis using the Mantel- Haenszel procedure identified risk factors associated with dengue mortality. Results. We analyzed 58 cases and 121 controls and identified four factors: in-hospital administration of dypirone (ORa=6.38 95%CI 2.41-16.86) and paracetamol (ORa=0.25 95%CI 0.10-0.61), comorbidities (ORa=3.52 95%CI 1.51-8.18), and a prior visit to the hospital (ORa=3.99 95%CI 1.63-9.77). Conclusions. Administration of dypirone in patients with severe dengue was associated with a higher risk of mortality. Considering that 20 countries have banned dipyrone because of its adverse effects, we advise against its use.


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