2021, Number 1
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Aten Fam 2021; 28 (1)
Association Between Treatments in Breast Cancer Patients with Clinical and Molecular Classification
Vázquez MFA, Gómez GA, Gutiérrez CS
Language: Spanish
References: 17
Page: 21-25
PDF size: 150.47 Kb.
ABSTRACT
Objective: to determine the types of
treatments in patients with breast cancer
according to a clinical and molecular
classification, in a Family Medicine
Unit.
Methods: a cross sectional study
based on the review of 88 files that
met the requirements of the selection
criteria. A data collection format was
designed to know the year breast cancer
was diagnosed, type of treatment, TNM
classification, and molecular profile.
The results are shown in frequencies,
mean and standard deviation.
Results:
the average age was 54.5 (±11.4 years),
most of the detected cancer types were
luminal B with 52% of cases, which
were mainly associated to adjuvant
chemotherapy (P=0.0001), while triple
negative ones were associated to radical
surgery (P=0.002). On the other hand,
the patients who required the most
neoadjuvant, adjuvant and surgical
treatment were in stage I at the time
of diagnosis, P=0.004, P=0.028 and
P=0.007, respectively.
Conclusions: correlating
treatment types with molecular
and TNM classification, it was observed
that a significant fraction of patients
with luminal B breast cancer required
adjuvant chemotherapy and radical surgery,
while most triple negative patients
required radical surgery.
REFERENCES
Kumar V, Abbas AK, Fausto N, Aster JC. Patología estructural y funcional. 2010. Elsevier. 1065- 1095.
Gómez Dantés H, Lamadrid Figueroa H, Cahuana Hurtado L, et al. The Burden of Cancer in Mexico, 1990-2013. Salud Pub Mex. 2016;58:118-131
Golditz G, Baer H, Tamimi R. Cancer Epidemiology and Prevention, 3rd ed, New York: Oxford Press, 2006.
Sánchez Ceja SG, Reyes Maldonado ME, Vázquez Manríquez ME, López Luna JJ, Belmont A y Gutiérrez Castellanos S. Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-smal-cell lung carcinoma. Lung Cancer. 2006;54:163-168.
Tavassoll FA, Devilee P. Word Healt Organization. Classification of Tumours. Pathology and genetics of tumours of the breast and female genital organs. International Agency for Research on Cancer, Press: Lyon 2003
Harris L, Fritsche H, Menuel R, Norton L, Ravdin P, et al. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 2007;25(33):5287-5312.
Consenso Mexicano sobre diagnóstico y tratamiento del cáncer mamario [Internet]. [Citado 2020 Nov 04]. Disponible en: http:// consensocancermamario.com/documentos/FOLLETO_ CONSENSO_DE_CANCER_DE_ MAMA_8aRev2019a.PDF
Russnes HG, Lingjaerde OC, Borresen Dale AL, Caldas C. Breast Cancer molecular stratification from intrinsic subtypes to integrative clusters. American Journal of Pathology. 2017;187(10):2152-2162.
Guía de práctica clínica, prevención y diagnóstico oportuno de cáncer de mama en el primer nivel de atención. Evidencias y recomendaciones. Centro Nacional de Excelencia Tecnológica en Salud (CENETEC). 2014.
Rodríguez Cuevas S, Macías Suárez G, Franceschi D. Breast carcinoma presents a decade earlier in Mexican women than in women in the United States or European countries. Cancer. 2011;91(4):863-868.
Maffuz Aziz A, Labastida Almendaro S, Espejo Fonseca A, et al. Clinical and pathological features of breast cancer in a population of Mexico. Cir Cir. 2017;85(3)201-207.
Franzoi MA, Rosa DD, Zaffaroni F, Werutsky G, Simon S, Bines J, et al. Advanced stage at diagnosis and worse clinocpathologic features in Young women with breast cáncer in Brazil: a subanalysis of the AMAZONA III study. J Glob Oncol. 2019;5:1-10.
Lester SC, Bose S, Chen YY, et al. Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast. College of American Pathologists. 2014;15:1-37.
Godoy Ortiz A, Sanchez Muñoz A, Chica Parrado MR, et al. Deciphering HER2 Breast Cancer Disease: Biological and Clinical Implications. Front Oncol. 2019;9:1124.
Brinton LA, Sherman ME, Carreon JD, Anderson WF. Recent trends in breast cancer among younger women in the United States. J Natl Cancer Inst. 2008;100(22):1643-1648.
Ades F, Zardavas D, Bozovic Spasojevic I, et al. Luminal B breast cancer: molecular characterization, clinical management, and future perspectives. J Clin Oncol. 2014;32(25):2794-2803.
Boér K. Adjuvant chemotherapy of early stage breast cancer. Orv Hetil. 2010;151(9):344-353.