2019, Number 3
<< Back Next >>
Rev Acta Médica 2019; 20 (3)
Characterization of cytological thyroid samples according to Bethesda consensus and histologic diagnosis
Dussac BGV, Tamargo BTO, Quesada PS
Language: Spanish
References: 43
Page: 1-17
PDF size: 231.74 Kb.
ABSTRACT
Introduction: Thyroid nodular disease manifests itself as thyroid nodules of solid, liquid or
mixed consistency, palpable or not, and it is a challenge to make an accurate diagnosis of a
benign or malignant disease.
Objective: To characterize the samples collected by fine-needle aspiration cytology of the
thyroid, according to the cytological diagnosis, Bethesda classification and histology.
Methods: A diagnostic evaluation research was carried out in the Pathological Anatomy
Department of Hermanos Ameijeiras Clinical-Surgical Hospital, between December 2015
and December 2016. The sample was 115 results of fine-needle aspiration cytology (113
patients). In each report, the cytological diagnosis was reviewed and the Bethesda
classification was applied. In the statistical analysis, the mean was used with its standard
deviation and percentages.
Results: The average age was 53.9±14.4 years, with 65.5% of female patients. 70.4% of the
cytology samples were not useful. According to Bethesda and cytology, 70.4% was
classified as I. In relation to the biopsy diagnosis and Bethesda classification, a follicular
hyperplasia was classified into category I. In class V, a high suspicion of lymphoma was
diagnosed. Papillary carcinoma occurred in 2 cases (group VI).
Conclusions: The Bethesda classification proved to be useful, because all the cytological
and histological malignant diagnoses were classified into the categories IV, V, or VI. Its use
is recommended to avoid an unnecessary number of surgeries.
REFERENCES
Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab. 2008;22 (6):901-11.
Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009;39 (8):699-706.
Tala H, Díaz RE, Domínguez Ruiz-Tagle JM, Sapunar Zenteno J, Pineda P, Arroyo Albala P, et al. Estudio y manejo de nódulos tiroideos por médicos no especialistas. Consenso SOCHED. Rev Med Chile. 2017;145:1028-37.
Román-González A, Restrepo Giraldo L, Alzate Monsalve C, Vélez A, Gutiérrez Restrepo J. Nódulo tiroideo, enfoque y manejo. Revisión de la literatura. Iatreia. 2013;26(2):197-206.
González F, Nicolau Mena O, Durruthy O, Guerra González WA. Nódulos del tiroides: incidentalomas. AMC. 2009 [citado 22 mayo 2018];13(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552009000400005&lng=es
Navarro Despaigne DA. Enfermedades del tiroides en Cuba. Rev Cubana Endocrinol. 2012;23(3):198-202.
Solarana Ortíz JA, Vera López R, Rodríguez Pascual Y, Velázquez Martín JI. Comportamiento de la enfermedad nodular del tiroides en el Servicio de Cirugía General del Hospital “Vladimir Ilich Lenin” de Holguín. CCM. 2013;17(3):275-83.
Jin J, Wilhelm SC, McHenry CR. Incidental thyroid nodule: patterns of diagnosis and rate of malignancy. Am J Surg. 2009;197(3):320-4.
Wilhelm SM, Robinson AV, Krishnamurthi SS. Evaluation and management of incidental thyroid nodules in patients with another primary malignancy. Surgery. 2007;142(4):581-7.
Rodríguez Fernández Z, Dorimain PCH, Falcón Vilariño GC, Mustelier Ferrer HL. Diagnóstico de los nódulos de tiroides mediante estudio citológico por punción y aspiración con aguja fina. MEDISAN. 2013;17(1)1-9.
Tallini G, Galla G. Fine-Neddle Aspiration and Intraoperative Consultation in Thyroid Pathology: When and How? International Journal of Surgical Pathology. 2011;19(2)141-4.
Dorimain PCH, Rodríguez Fernández Z, Rodríguez Sánchez LP, Falcón Vilariño GC, Mustelier Ferrer HL. Diagnóstico y tratamiento quirúrgico de pacientes con afecciones nodulares de tiroides. MEDISAN. 2013;17(11):8031-42.
Batsakis JG, Sueige N, el-Naggar AK. Fine needle aspiration of salivary glands: Its utility and tissue effects. Ann Otol Laryngol. 1992;101(2 Pt):185-88.
Mavec P, Eneroth CM, Franza S, Moberger G, Zajiceck J. Aspiration biopsy of salivary gland tumors. Correlation of cytologic reports from 652 aspiration biopsies whit clinical and histologic findings. Acta OtolaryngoI. 1964;58:471-87.
Pimienta Concepción I, Chávez García KA, Verano Gómez N, González Salas R, Camaño Carballo L, Machado Herrera PM, et al. Punción aspiración con aguja fina de nódulos tiroideos. Enfermería Investiga, Investigación, Vinculación, Docencia y Gestión. 2017;2(2):77-86.
Osorio C, Fernández A, Ensuncho C, Redondo K, Herrera F. Comparación entre la citología por aspiración con aguja fina y la biopsia por congelación en el diagnóstico de las neoplasias malignas de la glándula tiroides: un estudio prospectivo. Rev Colomb Cir. 2016;31:17-26.
Cibas ES, Ali Cibas SZ. The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid. 2017 Nov;27(11):1341-6. doi: 10.1089/thy.2017.0500.
Pereira Despaigne OL, Rodríguez Fernández Z, Dorimain PCH, Falcón Vilariño GC, Ochoa Marén G. Diagnóstico de las afecciones nodulares del tiroides. MEDISAN. 2015;19(6):786-96.
Periakaruppan G, Seshadri KG, Vignesh Krishna GM, Mandava R, Sai VPM, Rajendiran S. Correlation between Ultrasound-based TIRADS and Bethesda System for Reporting Thyroid-cytopathology: 2-year Experience at a Tertiary Care Center in India. Indian J Endocrinol Metab. 2018;22(5):651-5. doi: 10.4103/ijem.IJEM_27_18.
Castañeda Muñoz ÁM, Castro Morillo AM, Rufín Bergado AM, Ríos Serrano M, González Rodríguez D. Aplicación del sistema de Bethesda en la CAAF de tiroides. Rev. Med Electron. 2014;36(6):823-34.
Purushotham R, Akina P, Giriyan SS. Evaluation of Bethesda system for reporting thyroid cytology with histopathological correlation. Int J Res Med Sci. 2018 Jan;6(1):247- 52.
Herrera F, Redondo K, Osorio C, Grice J, Fernández A. Utilidad de la citología obtenida mediante aspiración con aguja fina en el diagnóstico de las neoplasias foliculares de la glándula tiroides en la E.S.E. Hospital Universitario del Caribe: un estudio retrospectivo. Rev Colomb Cir. 2015 [citado 22 mayo 2018];30:12-7. Disponible en:http://www.scielo.org.co/pdf/rcci/v30n1/v30n1a2.pdf
Cibas ES, Ali SZ. The Bethesda System for Reporting Thyroid Cytopathology. Am J Clin Pathol. 2009;132:658-65.
Ustun B, Chhieng D, Van Dyke A, Carling T, Holt E, Udelsman R, et al. Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. Cancer Cytopathol. 2014;122(7):536-45.
Pusztaszeri M, Rossi ED, Auger M, Baloch Z, Bishop J, Bongiovanni M, et al. The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel. Acta Cytol. 2016;60(5):399- 405. PubMed: PMID:27764825
Melo MA, Sanabria A, Romero A, Perez G, Vargas EJ, Abaunza MC, et al. The Bethesda system for reporting thyroid cytopathology in Colombia: Correlation with histopathological diagnoses in oncology and non-oncology institutions. J Cytol. 2015 [citado 22 Dic 2018;32(1):12-6. Disponible en: http://www.jcytol.org/article.asp?issn=0970- 9371;year=2015;volume=32;issue=1;spage=12;epage=16;aulast=Melo-Uribe
Infante A, Rodríguez Z, Ramos R. Características clínicas, ultrasonográficas y anatomopatológicas de pacientes operados por sospecha de malignidad tiroidea. Rev Cubana Endocrinol. 2014[citado 13 may 2018];25(2):35-45. Disponible en: http://scielo.sld.cu/pdf/end/v25n2/end01214.pdf
Awasthi P, Goel G, Khurana U, Joshi D, Majumdar K, Kapoor N. Reproducibility of "The Bethesda System for Reporting Thyroid Cytopathology:" A Retrospective Analysis of 107 Patients. J Cytol. 2018;35(1):33-6. PubMed: PMID: 29403167.
Güney G, Şahiner İT. Malignancy Rates of Thyroid Cytology: Cyst Fluid Benign or Non-Diagnostic? Med Sci Monit. 2017;23:3556-61.PubMed: PMID: 28729523.
Kim M, Kim JE, Kim Hj, Chung YR, Kwak Y, Park SY. Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillalry-like Nuclear Features and Its Impact on the Risk of malignancy in Bethesda System Reporting Thyroid Cytopathology: An Institucional Experiences. J Pathol Transl Med. 2018;52(3):171-8. PubMed: PMID: 29614546.
Periakaruppan G, Seshadri KG, Vignesh Krishna GM, Mandava R, Sai VPM, Rajendiran S. Correlation between Ultrasound-based TIRADS and Bethesda System for Reporting Thyroid-cytopathology: 2-year Experience at a Tertiary Care Center in India. Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):651-5. PubMed: PMID:30294576
Gao LY, Wang Y, Jiang YX, Yang X, Liu RY, Xi XH, et al. Ultrasound is helpful to differentiate Bethesda class III thyroid nodules: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2017;96(16):e6564. PubMed: PMID: 28422844.
Singaporewalla RM, Hwee J, Lang TU, Desai V. Clinico-pathological Correlation of Thyroid Nodule Ultrasound and Cytology Using the TIRADS and Bethesda Classifications. World J Surg. 2017 Jul;41(7):1807-1811. PubMed:PMID: 28251273
Mao F, Xu HX, Zhao CK, Bo XW, Li XL, Li DD et al. Thyroid imaging reporting and data system in assessment of cytological Bethesda Category III thyroid nodules. Clin Hemorheol Microcirc. 2017;65(2):163-73. PubMed: PMID:27589516
Rahal A Junior, Falsarella PM, Rocha RD, Lima JP, Iani MJ, Vieira FA, et al. Correlation of Thyroid Imaging Reporting and Data System [TI-RADS] and fine needle aspiration: experience in 1,000 nodules. Einstein (Sao Paulo) 2016;14(2):119-23. PubMed: PMID: 27462883
Erkan M, Canberk S, Kilicoglu GZ, Onenerk M, Uludokumaci A, Gunes P, et al. Avoidance of unnecessary fine-needle aspiration with the use of the Thyroid Imaging Reporting Data System classification and strain elastography based on The Bethesda System for Reporting Thyroid Cytopathology. Mol Clin Oncol. 2016 Nov;5(5):625-30. PubMed: PMID: 27900100
Maia FF, Matos PS, Pavin EJ, Zantut-Wittmann DE. Thyroid imaging reporting and data system score combined with Bethesda system for malignancy risk stratification in thyroid nodules with indeterminate results on cytology. Clin Endocrinol (Oxf). 2015;82(3):439-44. PubMed: PMID: 24930423
Ozdemir D, Bestepe N, Faki S, Kilicarslan A, Parlak O, Ersoy R. et al. Comparison of thyroid fine needle aspiration biopsy results before and after implementation of Bethesda classification. Cytopathology. 2017 Oct;28(5):400-06. PubMed: PMID: 28727204
Wesola M, Jeleń M. Bethesda System in the evaluation of thyroid nodules: Review. Ad Clin Exp Med. 2017;26(1):177-82. PubMed: PMID: 28397450
Turcios Tristá SE, Yanes Quesada M, Cruz Hernández J, Rodríguez González JC. Actualización de la conducta diagnóstica en el nódulo de tiroides. Rev Cubana Endocrinol. 2010 [citado 23 Nov 2018];21(3):333-9. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1561-29532010000300007&script=sci_arttext.
Chung SR, Baek JH, Choi YJ, Sung TY, Song DE, Kim TY, et al. The Role of Core Needle Biopsy for the Evaluation of Thyroid Nodules with Suspicious Ultrasound Features. Korean J Radiol. 2019 Jan;20(1):158-65. PubMed: PMID:30627031
Hahn SY, Shin JH, Han BK, Ko EY, Ko ES. Ultrasonography-guided core needle biopsy for the thyroid nodule: does the procedure hold any benefit for the diagnosis when fineneedle aspiration cytology analysis shows inconclusive results? Br J Radiol. 2013;86(1025):20130007. PubMed: PMID: 23564885
Park VY, Kim EK, Kwak JY, Yoon JH, Kim MJ, Moon HJ. Thyroid Imaging Reporting and Data System and Ultrasound Elastography: Diagnostic Accuracy as a Tool in Recommending Repeat Fine-Needle Aspiration for Solid Thyroid Nodules with Non- Diagnostic Fine-Needle Aspiration Cytology. Ultrasound Med Biol. 2016;42(2):399-06. PubMed: PMID: 26614385.