2004, Number s2
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Arch Cardiol Mex 2004; 74 (s2)
Biological importance of AT2 for Angiotensin-II
Escalante B
Language: Spanish
References: 5
Page: 284-286
PDF size: 67.65 Kb.
ABSTRACT
During arterial hypertension in the human being, it has been demonstrated that expression of AT-2 receptor for Angiotensin-II takes place. Presence of such receptor may be of functional importance to counteract arterial hypertension development because its stimulation produces a vasodilatador effect.
REFERENCES
Bader: Role of the local rennin-angiotensin system in cardiac damage: a minireview focusing on transgenic animal models. J Mol Cardiol 2002; 14: 1455-1462.
Timmermans PBMWMm, Chiu AT, Herblin WF, Wong PC, Smith RD: Angiotensin II receptor subtypes. Am J Hypertens 1992; 5: 406-410.
Matsubara H: Pathophysiology role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998; 83: 1182-1191.
de Gasparo M, Levens N: Does blockade of angiotensin II receptors offer clinical benefits over inhibition of angiotensin-converting enzyme? Pharmacology & Toxicology 1998; 82: 257-271.
Bautista R, Sanchez A, Hernández J, Oyekan A, Escalante B: Angiotensin II type AT2 receptor mRNA expression and renal vasodilation are increased in renal failure. Hypertension 2001; 38: 669-673.
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