2020, Number 3
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Rev Méd Electrón 2020; 42 (3)
Characterization of patients with intracranial ependymoma in the pediatric hospital
Sierra BEM, Hernández RG, Infante PM, Rodríguez RE
Language: Spanish
References: 20
Page:
PDF size: 420.16 Kb.
ABSTRACT
Introduction: ependymoma are almost 3-5 % of the intracranial tumors and 5-10 %
of the brain tumors in pediatric age.
Objective: to characterize the patients with intracranial ependymoma who underwent
surgery in the Pediatric Hospital ¨Juan Manuel Márquez.
Materials and method: retrospective, descriptive study of patients in pediatric age
with histological diagnosis of ependymoma of intracranial location in the period January
2012-December 2017. The universe was formed by all patients of pediatric age who
underwent surgery with histological diagnosis of intracranial ependymoma in the
before-mentioned place and period (N=22).
Results: the average age was 2.75 years with limits between 1 and 17 years old. Male
patients represented 63.64 %; the relation with female sex during the first 4 years was
1:1. Regarding the clinical characteristics, hydrocephaly predominated in 72.73 % of
patients. Intracranial ependymoma of infratentorial location (63.64 %) predominated.
45.45 % of the studied lesions corresponded to the histological subtype of anaplastic
ependymoma.
Conclusions: the combination of surgery, radiotherapy and chemotherapy was used in
most of the cases. The direct approach of the lesion through craniotomy and a removal
adequate to ependymoma location predominated. However, in most of them just the
resection of 50-90 % was achieved. The evolution of most of patients after the
diagnosis evidenced a tendency to the stability.
REFERENCES
Hübner JM, Kool M, Pfister SM, et al. Epidemiology, molecular classification and WHO grading of ependymoma. J Neurosurg Sci. 2018 Feb;62(1):46-50. Citado en PudMed; PMID: 28895660.
De B Khakoo Y, Souweidane MM, Dunkel IJ, et al. Patterns of relapse for children with localized intracranial ependymoma. J Neurooncol. 2018 Jun;138(2):435-45. Citado en PudMed; PMID: 29511977
Massimino M, Miceli R, Giangaspero F, et al. Final results of the second prospective AIEOP protocol for pediatric intracranial ependymoma. Neuro Oncol. 2016 Oct;18(10):1451-60. Citado en PudMed; PMID: 27194148
Ye J, Zhu J, Yan J, et al. Analysis on therapeutic outcomes and prognostic factors of intracranial ependymoma: a report of 49 clinical cases in a single center. Neurol Sci. 2015 Dec;36(12):2253-61. Citado en PudMed; PMID: 26216494.
Ailon T, Dunham C, Carret A-S, et al. The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience. Childs Nerv Syst. 2015 Jan;31(1):57-65. Citado en PudMed; PMID: 25391979.
Yaviv Y, Germano IM, Mahadevan A, et al. Surgery for posterior fossa ependymomas in adults. J Neurosurg Sci. 2018 Feb;62(1):63-70. Citado en PudMed; PMID: 28945053.
Lin FY, Chintagumpala M. Advances in Management of Pediatric Ependymomas. Curr Oncol Rep. 2015 Oct;17(10):47. Citado en PudMed; PMID: 26369328
Rudà R, Reifenberger G, Frappaz D, et al. EANO guidelines for the diagnosis and treatment of ependymal tumors. Neuro Oncol. 2018 Mar 27;20(4):445-456. Citado en PudMed; PMID: 29194500.
McGuire CS, Sainani KL, Fisher PG. Incidence patterns for ependymoma: A Surveillance, Epidemiology, and End Results study. J Neurosurg. 2009 Apr;110(4):725-9. Citado en PudMed; PMID: 19061350.
Marinoff AE, Ma C, Guo D, et al. Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival. J Neurooncol. 2017 Oct;135(1):201-211. Citado en PudMed; PMID: 28733870.
Bi Z, Ren X, Zhang J, et al. Clinical, radiological, and pathological features in 43 cases of intracranial subependymoma. J Neurosurg. 2015 Jan;122(1):49-60. Citado en PudMed; PMID: 25361493.
Gunther JR, Sato M, Chintagumpala M, et al. Imaging Changes in Pediatric Intracranial Ependymoma Patients Treated With Proton Beam Radiation Therapy Compared to Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015 Sep 1;93(1):54-63. Citado en PudMed; PMID: 26279024.
International Agency for Research on Cancer (IARC). WHO Classification of Tumours of the Central Nervous System[Internet]. 4th revised. Ginebra: Editorial Lyon: IARC; 2007[citado 18/11/19] . Disponible en: https://apps.who.int/bookorders/anglais/detart1.jsp?codlan=1&codcol=70&codcch=24 001#
Baxter P, Chitagumpala M. Ependymoma Revision. Texas Children´sCancer Center[Internet]; 2008 [ Citado 23/04/17 ]. Disponible en: http://www.texaschildrenshospital.com/CareCenters/Cancer/Perspectives/01- 08BaxterChintagSP.html
Haresh KP, Gandhi AK, Mallick S, et al. Prognostic Factors and Survival Outcomes of Intracranial Ependymoma Treated with Multimodality Approach. Indian J Med Paediatr Oncol. 2017 Oct-Dec;38(4):420-26. Citado en PudMed; PMID:29333005
Vera-Bolanos E, Aldape K, Yuan Y, et al. Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. Neuro Oncol. 2015 Mar;17(3):440-7. Citado en PudMed; PMID: 25121770.
Guo A, Suresh V, Liu X, et al. Clinicopathological features and microsurgical outcomes for giant pediatric intracranial tumor in 60 consecutive cases. Childs Nerv Syst. 2017 Mar;33(3):447-55. Citado en PudMed; PMID: 28180935
Lin C-T, Riva-Cambrin JK. Management of posterior fossa tumors and hydrocephalus in children: a review. Childs Nerv Syst. 2015 Oct;31(10):1781-9. Citado en PudMed; PMID: 26351230.
Leeper H, Felicella MM, Walbert T. Recent Advances in the Classification and Treatment of Ependymomas. Curr Treat Options Oncol. 2017 Aug 10;18(9):55. Citado en PudMed; PMID:28795287.
López-AE, Carolina SV, Cabrera BT, et al. Factores pronósticos y sobrevida de pacientes pediátricos con ependimomas. Gac Méd Méx[Internet]. 2009[citado 18/11/19] ;145(1):1-8. Disponible en: https://www.medigraphic.com/cgibin/ new/resumenI.cgi?IDARTICULO=20333