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2020, Number 1

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Rev Ciencias Médicas 2020; 24 (1)

Effects of calcium on body weight and blood pressure in spontaneously hypertensive rats

González CAE, Hernández RY, León GM, Vento PRA, Díaz LH

Language: Spanish
References: 25
Page: 1-13
PDF size: 380.87 Kb.


ABSTRACT

Introduction: the role of calcium in the control of body weight and blood pressure is important because it is a promising perspective in tackling obesity and hypertension.
Objective: to evaluate the effects of calcium administration on body weight and blood pressure in spontaneously hypertensive rats.
Methods: 20 spontaneously hypertensive adult rats were included and divided into two groups: an unsupplemented hypertensive (n=10) control group and an experimental group with hypertension that was given calcium for 6 weeks orally by cannula (10,000 mcg/day). Body weight and systolic, diastolic and mean blood pressure were weekly evaluated.
Results: calcium-supplemented animals showed a reduction in body weight compared to controls, this difference being statistically significant from week 6 (student t=2,712 p=0,014). The mean blood pressure of the experimental group decreased its values compared to the controls and the reduction was statistically significant after week 3. In the systolic and diastolic blood pressures there was a statistically significant decrease in the experimental group after the third week of supplementation (t=7,316 p=0,000) and (t=4,788 p=0,000), respectively.
Conclusions: calcium supplementation in rats spontaneously led to a reduction in body weight from week 6 onwards and reduced systolic, diastolic and mean blood pressure from week 3 onwards.


REFERENCES

  1. Alomaim H, Griffin P, Swist E, et al. Dietary calcium affects body composition and lipid metabolism in rats. PLoS One. [Internet] 2019 [citado 20/05/2019]; 14(1): [aprox. 1 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328234/

  2. Cormick G, Ciapponi A, Cafferata M, Belizán J. Suplementos de calcio para la prevención de la hipertensión primaria. Cochrane Database of Systematic Reviews [Internet] 2015 [citado 20/05/2019]; (6). Disponible en: https://www.cochrane.org/es/CD010037/suplementos-de-calcio-para-la-prevencion-de-la-hipertension-primaria

  3. Raj JP, Oommen AM, Paul TV. Dietary calcium intake and physical activity levels among urban South Indian postmenopausal women. J Family Med Prim Care [Internet]. 2015 [citado 20/05/2019]; 4(3): [aprox. 3 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535115/

  4. Chung M, Tang AM, Fu Z, Wang DD, Newberry SJ. Calcium intake and cardiovascular disease risk: An updated systematic review and meta-analysis. Ann Intern Med. [Internet]. 2016 [citado 20/05/2019]; 165(12): [aprox. 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27776363

  5. Felsenfeld AJ, Levine BS. Calcitonin, the forgotten hormone: Does it deserve to be forgotten? ClinKidney J. [Internet] 2015 [citado 20/05/2019]; 8(2): [aprox. 7 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25815174

  6. Trowman R, Dumville JC, Hahn S, Torgerson DJ. A systematic review of the effects of calcium supplementation on body weight. Br J Nutr [Internet]. 2006 [citado 20/05/2019]; 95(6): [aprox. 5 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/16768823

  7. Marotte C, Bryk G, Gonzales Chaves MM, Lifshitz F, de Portela ML, Zeni SN. Low dietary calcium and obesity: a comparative study in genetically obese and normal rats during early growth. Eur J Nutr [Internet]. 2014 [citado 20/05/2019]; 53(3): [aprox. 9 p.]. Disponible en: https://link.springer.com/article/10.1007/s00394-013-0581-z

  8. Sergeev IN, Song Q. High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res. [Internet]. 2014 [citado 20/05/2019]; 58(6): [aprox. 6 p.]. Disponible en: https://docksci.com/high-vitamin-d-and-calcium-intakes-reduce-diet-induced-obesity-in-mice-by-increa_5b07ae3ad64ab256697acc2e.html

  9. Malekzadeh JM, Keshavarz SA, Siassi F, Eshraghian M, Kadkhodaee M, Dorsty AR, et al. Dietary calcium had no reducing effect on body fat and weight gain in Sprague-dawley rats. Pakistan Journal of Nutrition. [Internet]. 2007 [citado 20/05/2019]; 6(5): [aprox. 6 p.]. Disponible en: http://docsdrive.com/pdfs/ansinet/pjn/2007/478-484.pdf

  10. Zhang Q, Tordoff MG. No effect of dietary calcium on body weight of lean and obese mice and rats. Am J Physiol Regul Integr Comp Physiol. [Internet]. 2004 [citado 20/05/2019]; 286(4): [aprox. 8 p.]. Disponible en: https://www.physiology.org/doi/full/10.1152/ajpregu.00655.2003

  11. Zemel MB. Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr [Internet]. 2004 [citado 20/05/2019]; 79(5): [aprox. 5 p.]. Disponible en: https://academic.oup.com/ajcn/article/79/5/907S/4690225

  12. Villarroel P, Villalobos E, Reyes M, Cifuentes M. Calcium, obesity, and the role of the calcium-sensing receptor. Nutr Rev. [Internet]. 2014 [citado 20/05/2019]; 72(10): [aprox. 10 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25182976

  13. McCarron DA. Calcium and magnesium nutritium in human hypertension. Ann Intern Med [Internet]. 1983 [citado 20/05/2019]; 98 (5 Pt 2): [aprox. 5 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/6847018

  14. Zemel MB, Shi H, Greer B, Diriezo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J [Internet]. 2000 [citado 20/05/2019]; 14: [aprox. 6 p.]. Disponible en: https://www.researchgate.net/profile/Douglas_Dirienzo2/publication/12483184_Regulation_of_adiposity_by_dietary_calcium/links/542c0d1f0cf27e39fa9219d7.pdf

  15. Davies KM, Heaney RP, Recker RR, et al. Calcium intake and body weight. J Clin Endocrinol Metab [Internet]. 2000 [citado 20/05/2019]; 85(12): [aprox. 3 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/11134120

  16. Barba G, Troiano E, Russo P, Venezia A, Siani A. Inverse association betweenbody mass and frequency of milk consumption in children. British Journal of Nutrition [Internet]. 2000 [citado 20/05/2019]. 2005; 93(1): 15-19. Disponible en: https://pdfs.semanticscholar.org/5d47/4bce02fcee138ef67f7342765b2e11941630.pdf

  17. Stern N, Lee DB, Silis V, et al. Effects of hight calcium intake on blood pressure and calcium metabolism in young SHR. Hypertension [Internet]. 1984 Oct [citado 20/05/2019]; 6(5): [aprox. 7 p.]. Disponible en: https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.6.5.639

  18. Skowrońska-Jóźwiak E, Jaworski M, Lorenc R, Karbownik-Lewińska M, Lewiński A. Low dairy calcium intake is associated with overweight and elevated blood pressure in Polish adults, notably in premenopausal women. Public Health Nutr [Internet]. 2017 [citado 20/05/2019]; 20(4): [aprox. 7 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/2784692621

  19. Moore-Schiltz L, Albert JM, Singer ME, Swain J, Nock NL. Dietary intake of calcium and magnesium and the metabolic syndrome in the National Health and Nutrition Examination (NHANES) 2001–2010 data. Br. J. Nutr [Internet]. 2015 [citado 20/05/2019]; 114(6): [aprox. 11 p.]. Disponible en: https://pdfs.semanticscholar.org/6b7e/1009f6646123b901794ca14af74f0408b1a7.pdf

  20. Faksová K, Brázdová ZD, Robertson A, et al. Nutritionally adequate food baskets optimised for cultural acceptability as basis for dietary guidelines for low-income Czech families. Nutr J 18 [Internet]. 2019 [citado 20/05/2019]; 84 (2019). Disponible en: https://nutritionj.biomedcentral.com/articles/10.1186/s12937-019-0510-y#citeas

  21. Kong SH, Kim JH, Hong AR, Cho NH, Shin CS. Dietary calcium intake and risk of cardiovascular disease, stroke, and fracture in a population with low calcium intake. Am. J. Clin. Nutr [Internet]. 2017 [citado 20/05/2019]; 106(1): [aprox. 7 p.]. Disponible en: https://academic.oup.com/ajcn/article/106/1/27/4634033

  22. Williams PT, Fortmann SP, Terry RB, Garay SC, Vranizan KM, Ellsworth N, et al. Associations of dietary fat, regional adiposity, and blood pressure in men. JAMA [Internet]. 1987 [citado 20/05/2019]; 257(23): [aprox. 5 p.]. Disponible en: https://www.researchgate.net/publication/19576178_Associations_of_Dietary_Fat_Regional_Adiposity_and_Blood_Pressure_in_Men

  23. Zhang B, Zhai FY, Du SF, Popkin BM. The China Health and Nutrition Survey, 1989-2011. Obes. Rev [Internet]. 2014 [citado 20/05/2019]; 15(Suppl 1): [aprox. 5 p.]. Disponible en: https://www.researchgate.net/publication/259348271_The_China_Health_and_Nutrition_Survey_1989-2011

  24. McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science [Internet]. 1984 [citado 20/05/2019]; 224(4656): [aprox. 6 p.]. Disponible en: https://science.sciencemag.org/content/224/4656/1392/tab-article-info

  25. Uso y Reproducción de los Animales para la Experimentación en el CENPALAB. CENPALAB. Edición 01/00; 2000.




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