medigraphic.com
ISSN 1561-3119 (Electronic)

2020, Number 3

<< Back Next >>

Rev Cubana Pediatr 2020; 92 (3)

Clinical-epidemiological characterization of pediatric patients with zika in epidemic

Tejeda HOO, Amaro RL, Sosa PO

Language: Spanish
References: 14
Page: 1-12
PDF size: 543.75 Kb.


ABSTRACT

Introduction: Zika virus is considerd as an emergent virus with no previous presence in the Cuban population.
Objective: To characterize clinically patients with confirmed Zika virus.
Methods: Descriptive cross-sectional study conducted in ´´Leonor Pérez´´ Pediatric Hospital between 2016 and 2017 during the epidemics. There were analyzed 140 clinical records of patients with zika confirmed by chain reaction of polymerase in serum and urine. There were measured clinical and laboratory variables and it was calculated the assisted rate.
Results: The assisted rate was 44.35 × 100 suspected cases. From the analyzed clinical records, 72.1% corresponded to the male sex and the average age was 10.9 ± 5.5 years. The chain reaction of polimerase was positive in a higher percentage of patients in urine than in serum: 52.1% and 40.7%, respectively and corresponding with the day when the urine sample was taken. Rash was present in 84.3% of the patients and fever in 70.0%. Pruritus, red eyes, cephalalgia, general discomfort, pain behind the eyes, odynophagia, arthralgia, anorexia and edemas were observed in less than 35.0% of the cases. The averages of the components of blood count with differential and the erythrocyte sedimentation were normal.
Conclusions: Rash and fever are the most frequent symptoms and the study of urine by chain reaction of polimerase informs of a higher number of positive patients than in the study of serum, according to the time of admittion. The routine complementary tests are not suggestive of zika in suspected cases.


REFERENCES

  1. Contigiani M, Levis S. Virus Zika (ZIKV). Internet] 2016 [acceso 08/01/2019] Disponible en: http://www.aam.org.ar/src/img_up/07032016.0.pdf

  2. Núñez E, Vásquez M, Beltrán Luque B, Padgett D. Virus Zika en Centroamérica y sus complicaciones. Ac Med Perú. 2016 [acceso 08/01/2019];33(1):42-9. Disponible en: http://www.scielo.org.pe/pdf/amp/v33n1/a08v33n1.pdf

  3. Ferreira-de-Brito A, Ribeiro LP, Moraes de Miranda R, Surubi Fernández R, Silva Campos S, Antunes Barbosa da Silva K, et al. First detection of natural infection of Aedes aegypti with Zika virus in Brazil and throughout South America. Mem Inst Oswaldo Cruz. 2016;111(10):655-658 Epub: 3 de octubre de 2016 Disponible en: https://doi.org/10.1590/0074-02760160332

  4. Dirección de Epidemiología y Demografía, Centro Nacional de Enlace–INS. ABECÉ sobre el virus de Zika. 2015 [acceso 21/01/2019]. Disponible en: https://pcnpost.com/abece-sobre-el-virus-de-zika/

  5. Peterson Lyle R, Jamieson Denise J, Powers Ann M, Honein AM. Zika virus. N Engl J Med. 2016; 374:1552-63.

  6. Campos Gubio C, Sardi IS, Sarno M, Brites C. Zika virus infection, a new public health challange. Braz J infect Dis. 2016 [acceso 08/01/2019];20(3):227-28. doi: http://dx.doi.org/10.1016/j.bjid.2016.05.001.

  7. Ferreira Barreto-Vieira D, Barth Ortrud M, Nunes da Silva MA, Cardosos Santos C, Da Silva Santos A, Batista Filho J, et al Ultrastucture of Zika virus particles in cell cultures. Mem Inst Oswaldo Cruz. 2016;111(8). doi: http: //dx.doi.org/10.1590/0074-02760160104.

  8. Noorbakhsh F, Abdolmohammadi K, Rezaci F. Zika virus Infection. Basic and Clinical Aspects: A Review Article. Iran J Public Health. 2019;48:20-31.

  9. OPS/OMS Zika-epidemiology report.CUBA, september 2017.Washington, D. C.: PAHO; 2017 [access 03/04/2019]. Disponible en: https://www.paho.org

  10. OPS.Instrumento para el diagnóstico y la atención a pacientes con sospecha de arbovirosis. Washington, D. C.: OPS; 2016.

  11. OPS/OMS. Actualización Epidemiológica, 28 de abril de 2016, Washington, D.C. OPS. 2016 [access 03/04/2019]. Disponible en: https//www.paho.org

  12. Read S, Torres Velasquez B, Lorenzi O, Rivera Sanchez A, Torres Torres S, Rivera LV, et al. Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico. JAMA Pediatr. 2018;172(7):686-93. PubMed PMID: 29813148.

  13. Burger Calderon R, Bustos Carrillo F, Gresh L, Ojeda S, Sanchez N, Plazaola M. Age-dependent manifestations and case definitions of pediatrics Zika: a prospective cohort study. Lancet infect Dis. 2019;20:1-10. doi: https://doi.org/10.1016/S1473-3099(19)30547-x.

  14. Troy Brown RN. La orina es mejor que la sangre para las pruebas de Zika. Biomédica. 2017 [acceso 23/01/2019];37(2):27-40 Disponible en: https://www.revistabiomedica.org/index.php/biomedica/article/download/3769/3688




2020     |     www.medigraphic.com