2020, Number 4
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An Med Asoc Med Hosp ABC 2020; 65 (4)
Transient cataract and permanent iris atrophy after subconjunctival 5-fluorouracil injection
Ledesma GJ, Gurría QLU
Language: Spanish
References: 7
Page: 301-304
PDF size: 346.55 Kb.
ABSTRACT
Accidental 5-FU into the anterior chamber after subconjunctival injection could produce transient cataract and iris atrophy, it is important to be careful in phakic patients. The main purpose of this report is to describe a case of transient cataract formation and iris atrophy after bled needling with 5-FU.
Case report: a 49-years-old female underwent subconjunctival injection of 5 mg 5-fluorouracil after trabeculectomy. Immediately after injection, she presented decrease visual acuity secondary to crystalline lens opacity, after six weeks visual acuity improved nevertheless iris atrophy remained. Visual acuity six months after was 20/25. In conclusion, transient cataract formation and iris atrophy can occur after accidental injection of 5-FU into the anterior chamber.
REFERENCES
Fagerli M, Lofors KT, Elsås T. Needling revision of failed filtering blebs after trabeculectomy: a retrospective study. Acta Ophthalmol Scand [Internet]. 2003 [cited 2020 Aug 17]; 81 (6): 577-582. Available from: https://pubmed.ncbi.nlm.nih.gov/14641257/
Shetty RK, Wartluft L, Moster MR. Slit-lamp needle revision of failed filtering blebs using high-dose mitomycin C. J Glaucoma [Internet]. 2005 [cited 2020 Aug 17]; 14 (1): 52-56. Available from: http://journals.lww.com/00061198-200502000-00010
Rockwood EJ, Parrish RK, Heuer DK, Skuta GL, Hodapp E, Palmberg PF et al. Glaucoma filtering surgery with 5-fluorouracil. Ophthalmology. 1987; 94 (9): 1071-1078.
Arnljots TS, Kasina R, Bykov VJN, Economou MA. Needling with 5-fluorouracil (5-fu) after xen gel stent implantation: 6-month outcomes. J Glaucoma [Internet]. 2018 [cited 2020 Aug 17]; 27 (10): 893-899. Available from: http://journals.lww.com/00061198-201810000-00010
Zheng L, Arvind H, Wechsler D. Outcomes: trabeculectomy bleb needle revision with 5-fluorouracil. J Glaucoma [Internet]. 2016 [cited 2020 Aug 17]; 25 (3): 317-323. Available from: http://journals.lww.com/00061198-201603000-00014
Libre PE. Transient, profound cataract associated with intracameral 5-fluorouracil. Am J Ophthalmol [Internet]. 2003 [cited 2020 Aug 17]; 135 (1): 101-102. Available from: https://pubmed.ncbi.nlm.nih.gov/12504710/
Rothman RF, Liebmann JM, Ritch R. Noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil. Am J Ophthalmol [Internet]. 1999 [cited 2020 Aug 17]; 128 (2): 236-237. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0002939499001154
EVIDENCE LEVEL
IV