Jaramillo JLI, Martínez SLM, Tabares RMD

Language: Spanish
References: 32
Page: 1-11
PDF size: 256.05 Kb.

ABSTRACT

Abnormal uterine bleeding is a term used for alterations in the regularity, duration and / or volume of menstrual bleeding and it is considered a common cause of medical consultation; sometimes it is a diagnostic challenge for the treating physician. Within the aetiology approach of said pathology, coagulopathies affect around 13% of women, and the most common is von Willebrand disease. The objective is to review the current scientific literature on the influence of von Willebrand disease in abnormal uterine bleeding. This is an inherited pathology derived from a deficiency of the von Willebrand factor responsible for platelet adhesion. The prevalence of this disease may be low, however, when studying the population of women with menorrhagia, the frequency can range from 5 to 20%. Different gynecological problems associated with von Willebrand disease have been described, such as menorrhagia, dysmenorrhea and a significant iron deficiency associated with it, in addition to a higher incidence of ovarian cysts, endometriosis, endometrial hyperplasia and endometrial polyps. The current literature suggests that those women with suggestive clinical symptoms should be screened. Regarding treatment, the literature reports the use of tranexamic acid and oral contraceptives, nonetheless desmopressin has proven to be most useful.

REFERENCES

1. James AH. Bleeding disorders in adolescents. Obstet Gynecol Clin North Am. 2009;36(1):153-62.

2. Zia A, Rajpurkar M. Challenges of diagnosing and managing the adolescent with heavy menstrual bleeding. Thromb Res. 2016;143:91-100.

3. Seravalli V, Linari S, Peruzzi E, Dei M, Paladino E, Bruni V. Prevalence of hemostatic disorders in adolescents with abnormal uterine bleeding. J Pediatr Adolesc Gynecol. 2013;26(5):285-9.

4. Committee on Adolescent Health Care; Committee on Gynecologic Practice. Committee Opinion No.580: von Willebrand disease in women. Obstet Gynecol. 2013;122(6):1368-73.

5. Pérez LE. Hemorragia uterina anormal: enfoque basado en evidencias. Revista Med. 2007;15(1):68-79.

6. Bannow BS, Konkle BA. Inherited Bleeding Disorders in the Obstetric Patient. Transfus Med Rev. 2018;32(4):237-43.

7. Berber E. The molecular genetics of von Willebrand disease. Turk J Haematol. 2012;29(4):313-24.

8. Lilicramp D, James P. Von Willebrand Disease: An Introduction for the Primary Care Physician. Treatment of Hemophilia. 2009;47.

9. Rahbar N, Faranoush M, Ghorbani R, Sadr B. Screening of Von Willebrand disease in iranian women with menorrhagia. Iran Red Crescent Med J. 2015;17(1):e18244.

10. Bradley L. Abnormal uterine bleeding. T Nurse Pract. 2005;30(10):38-49.

11. Cook R, Marques M. An Adolescent with a History of Menorrhagia. Lab Med. 2009;40(5):271-3.

12. Pavani K, Ram U. Von Willebrand Disease: An Overview. Indian J Pharm Sci. 2011;73(1): 7–16.

13. Laffan MA, Lester W, O’Donnell JS, Will A, Campbell R, Goodeve A, et al. The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology. Br J Haematol. 2014;167,453–65.

14. Curnow J, Pasalic L, Favaloro EJ. Treatment of von Willebrand Disease. Semin Thromb Hemost. 2016;42(2):133-46.

15. Bumbuliene Z, Sragyte D, Klimasenko J, Bumbul-Mazurek E. Abnormal uterine bleeding in adolescents: ultrasound evaluation of uterine volume. Gynecol Endocrinol. 2018:1-4

16. Lee CA, Abdul-Kadir R. von Willebrand Disease and Women’s Health. Semin Hematol. 2005;42(1):42-8.

17. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3-13.

18. Chodankar R, Critchley H. Biomarkers in abnormal uterine bleeding. Biol Reprod, 2018;0(0):1–12.

19. Cheong Y, Cameron IT, Critchley HOD. Abnormal uterine bleeding. Br Med Bull. 2017;123(1):103-14.

20. Spremović S, Stefanović A, Kadija S, Jeremić K, Sparić R. Classification and the diagnostics of abnormal uterine bleeding in non gravid women of reproductive age: the PALM-COEIN classification system adopted by the International Federation of Gynecology and Obstetrics. Vojnosanit Pregl. 2016;73(12):1154–9.

21. Kadir RA, Chi C. Women and von Willebrand Disease: Controversies in Diagnosis and Management. Semin Thromb Hemost. 2006;32:605–15.

22. Mikhail S, Kouides P. Prevalence and Treatment of von Willebrand Disease- Related Menorrhagia in Adolescents: A Review. Journal of Coagulation Disorders. 2009;000:(000).

23. Vo KT, Grooms L, Klima J, Holland-Hall C, O'Brien SH. Menstrual bleeding patterns and prevalence of bleeding disorders in a multidisciplinary adolescent haematology clinic. Haemophilia. 2013;19(1):71-5

24. Sherif N, Goubran H, Hassan A, Burnoufs T, El-Ekiaby M. An approach to outreach patients with von Willebrand disease in Egypt by targeting women with heavy menstrual bleeding and/or bleeding symptoms. Haemophilia. 2014;20:238–43.

25. Kumar S, Kishore R, Gupta V, Jain M, Shukla J. Prevalence and spectrum of von Willebrand disease in Eastern Uttar Pradesh. Indian J Pathol Microbiol. 2010;53(3):4869.

26. Janbabai G, Samaneh S, Ahmadinejad M. Frequency of Bleeding Disorders in Women Presenting with Menorrhagia in North of Iran. World Appl Sci J. 2013;23(1):01-6.

27. Elmaoğulları S, Aycan Z. Abnormal Uterine Bleeding in Adolescents. J Clin Res Pediatr Endocrinol. 2018;10(3):191-7.

28. Munro MG. Classification of menstrual bleeding disorders. Rev Endocr Metab Disord. 2012;13(4):225-34.

29. Munro MG, Critchley H, Fraser I. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynecol Obstet. 2018;143:393–408.

30. Rodeghiero F. Management of menorrhagia in women with inherited bleeding disorders: general principles and use of desmopressin. Haemophilia. 2008;14(1):21–30.

31. Deligeoroglou E, Karountzos V. Abnormal Uterine Bleeding including coagulopathies and other menstrual disorders. Best Pract Res Clin Obstet Gynaecol. 2018;48:51-61.

32. Ragni MV, Machin N, Malec LM, James AH, Kessler CM, Konkle BA, et al. Von Willebrand factor for menorrhagia: a survey and literature review. Haemophilia. 2016;22:397–402.