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Organo Oficial de la Sociedad Mexicana de Urología

2020, Number 5

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Rev Mex Urol 2020; 80 (5)

Urologic manifestations of IgG4-related disease

Montaño-Roca BE, Vanacore D, Gallegos-Sánchez G, Rosales-Velázquez CE, Ruvalcaba-Oceguera GE, Aragón-Castro MA, Gutiérrez-Rosales R, Boissier R

Language: English
References: 36
Page: 1-10
PDF size: 194.46 Kb.


ABSTRACT

IgG4-related disease (IgG4-RD) is a clinical entity characterized by elevated serum IgG4 and tumor-like inflammation, with tissue infiltration by IgG4 and plasma cells. IgG4-RD is rare, but clinically significant, and its urologic manifestations have been reported in the literature. The present review covers a broad spectrum, describing the pathologies related to the area of urology.
In 2003, Terumi Kamisawa was the first to recognize IgG4-RD, characterized by multiorgan lesions in patients with autoimmune pancreatitis and classified as an inflammatory and fibrotic entity with a dense lymphoplasmacytic infiltrate, positive for IgG4. It presents in middle- aged patients, between 59-68 years of age, with no clear distribution by sex, and has different clinical presentations. The main urologic manifestations are inflammatory pseudotumors and lower urinary tract symptoms. The present article offers a clear, general overview of the disease, encompassing its pathophysiology, diagnosis, and treatment, from the perspective of urology.


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