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2020, Number 3

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Rev Educ Bioquimica 2020; 39 (3)

La respuesta pro-inflamatoria en la intoxicación por plomo

López VNC, Calderón SJV

Language: Spanish
References: 32
Page: 71-82
PDF size: 831.10 Kb.


ABSTRACT

The inflammation phenomenon begins when there are disturbances of cellular and tissue homeostasis. The recognition of pathogen or damage in cells and tissues trigger a response that involves physiological and pathological mechanisms, especially of the immune system. Despite the molecular basis of inflammation is well described, in diseases with chronic and pro-inflammatory processes, such as the lead intoxication is not fully known. Therefore, it is necessary to study these processes to understand the pathology and its complications. In the present work we explain the molecular pathways of the inflammatory cascade, from the agent or damage recognition, the pathway of cytokines release, vascular and cellular effects, to the inflammation resolution. Also, we described the effects that the lead exposure has over elements of the inflammatory and immune response, it is reported in exposed populations and lead exposed workers.


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