2019, Number 4
Histopronostic factors of mortality in women surgically operated for infiltrating ductal carcinoma of the breast
Language: Spanish
References: 19
Page: 424-434
PDF size: 403.24 Kb.
ABSTRACT
Introduction: breast cancer is a growing and challenging problem for health services worldwide. It is the first cause of death by cancer in women in the world and the second cause of death in Cuba by malignant tumors.Objective: to determine the possible association between histopronostic factors and the mortality of women surgically intervened for infiltrating ductal carcinoma of the breast.
Method: an analytical observational study of cases and controls was carried out in the Pathology Department of the General Provincial Teaching Hospital Dr. “Antonio Luaces Iraola” of Ciego de Ávila, in the period from January 2002 to December 2017. It worked with the population of 303 women. The cases were the patients who died in that period of time and the controls who survived.
Results: the age group of 54-60 years (34,32 %) and grades I and II (82,84 %) predominated. In almost all of the deaths the tumor exceeded 10 mm (17,82 %) with a risk of 13,3 times; in more than half there were more than three affected nodes (11,22 %) with a 29-fold risk and vasculolymphatic invasion (21,54 %) with a 3,4-fold risk.
Conclusions: as histopronostic factors, tumor size greater than 10 mm, lymph node metastases and vasculolymphatic invasion were statistically significant, demonstrating their association with mortality.
REFERENCES
Duarte-Muñoz F, Calix ES, Santos R. Caracterización epidemiológica de pacientes con cáncer de mama, admitidas en el Centro de Cáncer Emma Romero de Callejas 1999 a 2009. Rev Fac Cienc Méd [Internet]. 2011 [citado 22 Jun 2017];8(2):32-44. Disponible en: http://cidbimena.desastres.hn/RFCM/pdf/2011/pdf/RFCMVol8-2-2011.pdf#page=33
García-Soto J, Busto-Hidalgo J, Hernández-Menéndez M, Schery-Guedez O, García Busto JA.Factores epidemiológicos relacionados con el cáncer de mama. Hospital “José Ramón López Tabrane”. Provincia Matanzas. 2010-2015. Rev Med Electrón [Internet]. Feb 2019 [citado 10 May 2019];41(1):104-16. Disponible en: http://scielo.sld.cu/pdf/rme/v41n1/1684-1824-rme-41-01-104.pdf
Socorro-Palomino DE, Núñez-Morgado LR, Estrada-Espinosa EM, Delgado-Moya R, Alpízar- Becil D, Jiménez-Álvarez R. Factores histopronósticos de las variedades especiales de carcinoma infiltrante de la mama femenina. MediCiego [Internet]. 2019 [citado 28 Abr 2019];25(1):21-8. Disponible en: http://www.revmediciego.sld.cu/index.php/mediciego/article/download/929/1524
Brancato CA, Cortese EM, Blanco, MLC, Poledri MF, Gil LE, Rossini MR, Paiz MC, Ortiz SM. Cáncer de mama en pacientes mayores de 70 años. Rev Argent Mastol [Internet]. 2012 [citado 23 May 2017];31(113):383-93. Disponible en: http://www.revistasamas.org.ar/revistas/2012_v31_n113/cancer_de_mama_en_pacientes_mayores_m13.pdf
Maffuz-Aziz A, Labastida-Almendaro S, Sherwell-Cabello S, Ruvalcaba-Limón E, Domínguez- Reyes CA, Tenorio Torres JA, et al. Supervivencia de pacientes con cáncer de mama. Análisis por factores pronóstico, clínicos y patológicos. Ginecol Obstet Méx [Internet]. Ago 2016 [citado 4 Ene 2019];84(8):498-506. Disponible en: http://www.medigraphic.com/pdfs/ginobsmex/gom-2016/gom168e.pdf
Rakha EA, Ellis I. Invasive ductal carcinoma of no special type and histologic grade. En: Dabbs DJ, editor. Breast Pathology. [Internet] 2da ed. Philadelphia: Elsevier; 2017. p. 491-507. [citado 28 Abr 2019] Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/3-s2.0-B978032338961700023X.pdf?locale=es_ES&searchIndex=