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2019, Number 3

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Cuba y Salud 2019; 14 (3)

Neuroinflammation and Parkinson’s Disease

Pavón FN, Lorigados PL

Language: Spanish
References: 50
Page: 44-49
PDF size: 303.95 Kb.


ABSTRACT

Objective: to review and discuss the role that neuroinflammatory mechanisms play in Parkinson’s disease and in animal models of this disease.
Development: a group of evidences is shown that relate the activation of microglia and the processes of degeneration of dopaminergic cells. Peripheral T lymphocytes infiltrate the parenchyma of the Central Nervous System at the site of neuronal injury both in humans with Parkinson’s disease and in models of parkinsonism. The cell-mediated immune response contributes to the degeneration of dopaminergic cells through the cytotoxic mechanisms dependent on Fas / FasL binding. The role of several hypotheses that could be related to changes in the immune response is discussed.
Conclusions: the mechanisms discussed here allow us to support the potential use of immunomodulatory drugs as neuroprotective agents to delay the degenerative nigrostriatal process.


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