medigraphic.com
ISSN 1561-3054 (Electronic)

2020, Number 1

<< Back Next >>

Rev Cubana Med Trop 2020; 72 (1)

Human papillomavirus infection among women from Cañar Canton in Ecuador

Carrión OJI, Soto BY, Pupo AM

Language: Spanish
References: 30
Page: 1-20
PDF size: 285.04 Kb.


ABSTRACT

Introduction: Few studies are available about the circulation of human papillomavirus among Ecuadorian women, particularly those from Cañar Canton.
Objectives: Determine the circulation of human papillomavirus, alterations in the cervicalvaginal cytology of women from Cañar Canton, and the behavior of some sociodemographic and clinical-epidemiological variables.
Methods: An analytical cross-sectional study was conducted from July 2017 to September 2018. Cervical cells were collected from 100 women aged 15-55 years to determine viral infection and cytological alterations. An analysis was performed of the relationship of sociodemographic and clinical-epidemiological variables to viral infection.
Results: Of the women examined, 51% (51/100) tested positive for the virus, with a predominance of oncogenic genotypes. Genotype 31 was the most common (56.9%; 29/51), followed by genotype 58 (43.1%; 22/51). Women aged over 50 years had a lesser probability of being infected (3.9%; 2/51). Infection probability was greater among single women, with a history of sexually transmitted infections, who suffered from inflammatory cervical processes, and smokers. Infection by genotype 66 was associated to the use of hormonal contraceptives (53.3%; 8/15); p= 0.045, PR= 3.08 CI95% (1.00-9.46). Of the sample cytologies, 97% were negative for malignancy; no case was diagnosed of high-grade lesions.
Conclusions: The high prevalence of infection by oncogenic genotypes, as opposed to the low frequency of positive cytologies, points to the need to implement efficient programs aimed at early detection of cervical cancer in the population of Cañar Canton, as well as sexual and reproductive education campaigns.


REFERENCES

  1. de Villiers EM. Cross-roads in the classification of papillomaviruses. Virology [Internet]. 2013 [acceso 20/09/2019];445(1-2):2-10. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S0042682213002456.pdf?locale=es_ES&searchIndex=

  2. Rader JS, Tsaih SW, Fullin D, Murray MW, Iden M, Zimmermann MT, et al. Genetic variations in human papillomavirus and cervical cancer outcomes. Int J Cancer [Interenet]. 2019 mayo [acceso 20/09/2019];144(9):2206-14. Disponible en: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.32038

  3. Basto DL, Vidal JP, Pontes VB, Felix SP, Pinto LC, Soares BM, et al. Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil. Arch Virol [Internet]. 2017 septiembre [acceso 20/09/2019];162(9):2855-60. Disponible en: https://link.springer.com/content/pdf/10.1007%2Fs00705-017-3439-5.pdf

  4. Marin HM, Torres C, Deluca GD, Mbayed VA. Human papillomavirus detection in Corrientes, Argentina: High prevalence of type 58 and its phylodynamics. Rev Argent Microbiol [Internet]. 2015 octubre-diciembre [acceso 20/09/2019];47(4):302-11. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S0325754115001194.pdf?locale=es_ES&searchIndex=

  5. Sanchez GI, Bravo LE, Hernandez-Suarez G, Tous S, Alemany L, de Sanjose S, et al. Secular trends of HPV genotypes in invasive cervical cancer in Cali, Colombia 1950- 1999. Cancer Epidemiol [Internet]. 2016 febrero [acceso 21/09/2019];40:173-8. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S1877782115002866.pdf?locale=es_ES&searchIndex=

  6. Bedoya-Pilozo CH, Medina Magues LG, Espinosa-Garcia M, Sanchez M, Parrales Valdiviezo JV, Molina D, et al. Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador. Rev Argent Microbiol [Internet]. 2018 abril-junio [acceso 21/09/2019];50(2):136-46. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S0325754117301372.pdf?locale=es_ES&searchIndex=

  7. Rendle KA, Schiffman M, Cheung LC, Kinney WK, Fetterman B, Poitras NE, et al. Adherence patterns to extended cervical screening intervals in women undergoing human papillomavirus (HPV) and cytology cotesting. Prev Med [Internet]. 2018 abril [acceso 21/09/2019];109:44-50. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S009174351730511X.pdf?locale=es_ES&searchIndex=

  8. Vaccarella S, Lortet-Tieulent J, Plummer M, Franceschi S, Bray F. Worldwide trends in cervical cancer incidence: impact of screening against changes in disease risk factors. Eur J Cancer [Internet]. 2013 octubre [acceso 21/09/2019];49(15):3262-73. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S0959804913003584.pdf?locale=es_ES&searchIndex=

  9. Mancilla JC. Public expenditure in health in Ecuador. Rev Med. FCM-UCSG [Internet]. 2012 [acceso 21/09/2019];18(1):53-60. Disponible en: https://www.researchgate.net/publication/340569350_Gasto_publico_en_salud_en_el_ Ecuador

  10. Asotic A, Taric S, Asotic J. Correlation of cervical smear and pathohistological findings. Med Arch [Internet]. 2014 abril [acceso 21/09/2019];68(2):106-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272497/pdf/MA-68-106.pdf

  11. Noller KL. Intraepithelial neoplasia of the lower genital tract (cervix, vulva): etiology, screening, diagnostic techniques, management In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, editors. Comprehensive Gynecology. 5th ed. Philadelphia, Pe: Mosby Elsevier; 2007.

  12. Ritu N, Wilbur DC. The Bethesda System for Reporting Cervical Cytology [monografía en Internet]. 3rd ed. Chicago, IL. USA: Springer; 2014 [acceso 22/09/2019]. Disponible en: http://fosp.saude.sp.gov.br:443/docs/The+Bethesda+System+for+Reporting+Cervic.pd f

  13. Tardif KD, Pyne MT, Malmberg E, Lunt TC, Schlaberg R. Cervical Cytology Specimen Stability in Surepath Preservative and Analytical Sensitivity for HPV Testing with the cobas and Hybrid Capture 2 Tests. PLoS One [Internet]. 2016 febrero [acceso 22/09/2019];11(2):e0149611. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764333/pdf/pone.0149611.pdf

  14. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, et al. A review of human carcinogens--Part B: biological agents. Lancet Oncol [Internet]. 2009 abril [acceso 22/09/2019];10(4):321-2. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0- S1470204509700968.pdf?locale=es_ES&searchIndex=

  15. Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA [Internet]. 2018 julio [acceso 22/09/2019];310(20):2191-4. Disponible en: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principlesfor- medical-research-involving-human-subjects/

  16. Banister CE, Messersmith AR, Chakraborty H, Wang Y, Spiryda LB, Glover SH, et al. HPV prevalence at enrollment and baseline results from the Carolina Women's Care Study, a longitudinal study of HPV persistence in women of college age. Int J Womens Health [Internet]. 2013 julio [acceso [acceso 21/09/2019];5:379-88. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/?term=HPV+prevalence+at+enrollment+and+b aseline+results+from+the+Carolina+Women%27s+Care+Study%2C+a+longitudinal+ study+of+HPV+persistence+in+women+of+college+age.+Int+J+Womens+Health

  17. McHugh KE, Reynolds JP, Suarez AA. Postmenopausal Squamous Atypia: Cytologic Features, Hybrid Capture 2 Tests and Contribution to the ASCUS Pool. Acta Cytol [Internet]. 2018 [acceso 23/09/2019];62(5-6):418-22. Disponible en: https://www.karger.com/Article/Abstract/490691

  18. Nugus P, Desalliers J, Morales J, Graves L, Evans A, Macaulay AC. Localizing Global Medicine: Challenges and Opportunities in Cervical Screening in an Indigenous Community in Ecuador. Qual Health Res [Internet]. 2018 [acceso 23/09/2019];28(5):800-12. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/?term=Challenges+and+Opportunities+in+Cer vical+Screening+in+an+Indigenous+Community+in+Ecuador

  19. Lee CH, Peng CY, Li RN, Chen YC, Tsai HT, Hung YH, et al. Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes. Int J Cancer [Internet]. 2015 [acceso 23/09/2019];136(2):340-9. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/24841989

  20. Kitchener HC, Castle PE, Cox JT. Chapter 7: Achievements and limitations of cervical cytology screening. Vaccine [Internet]. 2006 [acceso 23/09/2019];24(Suppl 3):S3/63-70. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/16950019

  21. Bruni L, Diaz M, Castellsague X, Ferrer E, Bosch FX, de Sanjose S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis [Internet]. 2010 [acceso 23/09/2019];202(12):1789-99. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/21067372

  22. Aguilar-Lemarroy A, Vallejo-Ruiz V, Cortes-Gutierrez EI, Salgado-Bernabe ME, Ramos-Gonzalez NP, Ortega-Cervantes L, et al. Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: typespecific prevalence and HPV coinfections. J Med Virol [Internet]. 2015 mayo [acceso 24/09/2019];87(5):871-84. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.24099

  23. Badano I, Pedrozo RW, Ruiz Diaz LS, Galuppo JA, Picconi MA, Campos RH, et al. Detección del virus papiloma humano (HPV) y citología de Papanicolaou en mujeres de bajos recursos de la ciudad de Posadas, Misiones, Argentina. Rev Argent Microbiol [Internet]. 2011 julios-septiembre [acceso 24 de septiembre de 2019];43(4):263-7. Disponible en: http://www.scielo.org.co/pdf/rcog/v68n3/0034-7434-rcog-68-03- 00202.pdf

  24. Bruno A, Serravalle K, Travassos AG, Lima BG. Genotype distribution of human papillomavirus in women from the state of Bahia, Brazil. Rev Bras Ginecol Obstet [Internet]. 2014 septiembre [acceso 24/09/2019];36(9):416-22. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25272363

  25. Ortega-Cervantes L, Aguilar-Lemarroy A, Rojas-Garcia AE, Barron-Vivanco BS, Vallejo-Ruiz V, Leon DC, et al. Human papilloma virus genotypes in women from Nayarit, Mexico, with squamous intraepithelial lesions and cervical cancer. Intern J Health Sci [Internet]. 2016 julio-septiembre [acceso 21/09/2019];10(3):327-38. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003576/pdf/ijhs-10-3- 327.pdf

  26. de Sanjose S, Wheeler CM, Quint WG, Hunt WC, Joste NE, Alemany L, et al. Agespecific occurrence of HPV16-and HPV18-related cervical cancer. Cancer Epidemiol Biomarkers Prev. 2013 Jul;22(7):1313-8.

  27. Brown CR, Leon ML, Munoz K, Fagioni A, Amador LG, Frain B, et al. Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinic. Braz J Med Biol Res [Internet]. 2009 julio [acceso 24/09/2019];42(7):629-36. Disponible en: http://www.scielo.br/pdf/bjmbr/v42n7/7514.pdf

  28. Puerto D, Reyes V, Lozano C, Buitrago L, Garcia D, Murillo RH, et al. Detection and Genotyping of HPV DNA in a Group of Unvaccinated Young Women from Colombia: Baseline Measures Prior to Future Monitoring Program. Cancer Prev Res (Phila) [Internet]. 2018 septiembre [acceso 24/09/2019];11(9):581-92. Disponible en: https://cancerpreventionresearch.aacrjournals.org/content/11/9/581.full-text.pdf

  29. Wei L, Griego AM, Chu M, Ozbun MA. Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes. Carcinogenesis [Internet]. 2014 octubre [acceso 24/09/2019];35(10):2373-81. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178472/pdf/bgu156.pdf

  30. Vinodhini K, Shanmughapriya S, Das BC, Natarajaseenivasan K. Prevalence and risk factors of HPV infection among women from various provinces of the world. Arch Gynecol Obstet [Internet]. 2012 marzo [acceso 24/09/2019];285(3):771-7. Disponible en: https://link.springer.com/content/pdf/10.1007%2Fs00404-011-2155-8.pdf




2020     |     www.medigraphic.com