2020, Number 1
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Vet Mex 2020; 7 (1)
Use of medetomidine, midazolam, ketamine and sevoflurane as an anesthetic protocol for domestic chickens
Celik Y, Atalan G, Güne V, Alpman U, Kaan YM
Language: English/Spanish
References: 33
Page: 1-12
PDF size: 272.68 Kb.
ABSTRACT
Changes in physiological and biochemical parameters after administration
of medetomidine (MED), midazolam (MID), ketamine (KET) and a 2% of
the inhalation anesthetic sevoflurane (SEVO), were investigated in domestic
chickens. The anesthetic protocol began with a simultaneous intrapectoral
injection (IP) of MED (50 μg/kg) and MID (0.5 mg/kg), followed by IP administration
of 25 mg/kg of KET 10 min later. Anesthesia was then maintained
for 30 min by 2% SEVO (with a 500 ml/min oxygen flow), using an
Ayres T piece device. Heart and respiratory rates, cloacal temperature, reflex
response and electrocardiogram (ECG) parameters were recorded at time
zero (T0) before anesthesia (BA, baseline values), at time of MED + MID administration
(T1), at time of ketamine injection (T2), 30 min after the start of
SEVO inhalation (T3) and at recovery. Blood was also drawn at T0 and T3 to
assess albumin, creatinine, glucose and liver enzyme concentrations. Cloacal
temperature, heart and respiratory rates differed from baseline values at all
time intervals during anesthesia (p ‹ 0.05). Heart rate decreased following
the MED + MID injection (at T1, T2 and T3), and partially recovered by the
reanimation period. Reflex response also differed between time 0 and all
anesthesia time points (p ‹ 0.05). Mean amplitude of the P wave of the ECG
was increased during MED + MID (T1) and KET (T2) anesthesia. The mean
ST interval showed a large increase at T1, which was maintained throughout
anesthesia (p ‹ 0.05). Albumin, glucose and the ALT enzyme decreased
between T0 and T3. In conclusion, the use of MED + MID + KET and SEVO as an anesthetic combination altered cardiorespiratory and biochemical parameters
of chickens, but no life-threatening effects were observed as a result
of these changes. Hence, this drug combination can be adequately used as
an anesthesia protocol in chickens.
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