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Organo Oficial de la Asociación Mexicana de Mastología

2019, Number 2-3

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Rev Mex Mastol 2019; 9 (2-3)

Length of telomeres and obesity in women with breast cancer

Murillo-Ortiz B, Martínez-Garza S, Suárez-García D, García-Regalado F, Aboytes-Ríos B

Language: Spanish
References: 23
Page: 53-61
PDF size: 272.52 Kb.


ABSTRACT

Introduction: Recently, epidemiological studies have linked the presence of obesity with the risk of breast cancer in post-menopausal women. The increase in risk is based on the effect of elevated serum levels of estrogen by the aromatization of peripheral fat. The aromatization of fatty tissue increases estradiol levels and this exerts an effect on the expression of a variety of genes involved in proliferation, morphogenesis, and programmed cell death. Objective: To know the relationship between telomere length with obesity and risk factors in women with mammary carcinoma. Methods: This is a descriptive cross-sectional study in 57 patients with a diagnosis of breast carcinoma in oncological treatment. The patients were invited to participate and once their consent was signed, a clinical history and nutritional assessment was made, a 5 mL blood sample was taken in fasting for the extraction of DNA for the measurement of telomere length using real-time PCR. Results: The mean age was 58.74 ± 11.45 years. The median BMI was 30, 51% were overweight and 40% obesity. 32% obesity grade II, 26% obesity grade I and 9% with normal weight. 44% were diagnosed in stage II B, 50% in stage III A. The most frequent histopathological strain was infiltrating ductal carcinoma in 58% of the cases and 54% with intermediate degree of malignancy. The length of the telomeres showed a median of 2256.7 bp (288.1-16844.42). The relationship between telomere length and BMI could not be demonstrated (p › 0.05). A shorter telomere could be observed in the youngest group (30 to 39 years) compared to older patients (70 and over) a significant difference was observed (1488 ± 50 vs 2103.85 ± 109 pb, p = 0.001). Conclusions: The present study showed that there is no relationship between the BMI and the length of the telomeres. What could be observed was that at younger age the average length of the telomeres was lower, showing also this tendency in the patients who received treatment with radiotherapy.


REFERENCES

  1. Secretaría de Salud. Salud México 2002. Información para la rendición de cuentas. México, D.F.: Dirección General de Información y Evaluación del Desempeño, SSA; 2003.

  2. Sasano H, Suzuki T, Nakata T, Moriya T. New development in intracrinology of breast carcinoma. Breast Cancer. 2006; 13 (2): 129-136.

  3. Misitini S, Nanny S, Fontemaggi G, Cong YS et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Moll Cell Biol. 2000; 20 (11): 3764-3771.

  4. Shen J, Terry MB, Gurvich I, Liao Y, Senie RT, Santella RM. Short telomere length and breast cancer risk: a study in sister sets. Cancer Res. 2007; 67 (11): 5538-5544.

  5. Yan W, Zhibin H, Jie L, Zhanwei W, Jhinai T, Shui W et al. A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women. Carcinogenesis. 2008; 29 (6): 1197-1201.

  6. Shay JW, Zou Y, Hiyama E, Wright W. Telomerase and cancer. Human Molecular Genetics. 2001; 10 (7): 677-685.

  7. Bayne S, Jones MEE, Li H, Pinto AR, Simpson ER, Liu J. Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice. Cell Research. 2008; 18: 1141-1150.

  8. Heaphy CM, Baumgartner KB, Bisoffi M, Baumgartner RN, Griffinth JK. Telomere DNA content predicts breast cancer-free survival interval. Clin Cancer Res. 2007; 13 (23): 7037-7043.

  9. Umbricht CB, Sherman ME, Dome J, Carey LA, Marks J, Kim N et al. Telomerase activity in ductal carcinoma in situ and invasive breast cancer. Oncogene. 1999; 18: 3407-3414.

  10. Elenitoba-Johnson KS. Complex regulation of telomerase activity: implications for cancer therapy. Am J Pathol. 2001; 159 (2): 405-410.

  11. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acid Research. 2002; 30 (10): 47-53.

  12. McGath M, Wong JY, Micahud D, Hunter DJ, de Vivo I. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev. 2007; 16 (4): 815-819.

  13. Artandi SE. Telomeres, telomerase, and human disease. N Engl J Med. 2006; 355 (12): 1195-1197.

  14. Svenson U, Nordfjäll K, Stegmayr B, Manjer J, Nilsson P, Tavelin B et al. Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res. 2008; 68 (10): 3618-3623.

  15. Svenson U, Ljungberg B, Roos G. Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma. Cancer Res. 2009; 69 (7): 2896-2901.

  16. Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN et al. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res. 2010; 70 (8): 3170-3176.

  17. De Vivo I, Prescott J, Wong JY, Kraft P, Hankinson SE, Hunter DJ. A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers. 2009; 18 (4): 1152-1156.

  18. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y et al. Estrogen activates telomerase. Cancer Res. 1999; 59: 5917-5921.

  19. Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK et al. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res. 2011; 4: 1021-1029.

  20. Whiteman MK, Hillis SD, Curtis KM, McDonald JA, Wingo PA, Marchbanks PA. Body mass and mortality after breast cancer diagnosis. Cancer Epidemiol Biomarkers Prev. 2005; 14: 2009-2014.

  21. Majed B, Moreau T, Senouci K, Salmon RJ, Fourquet A, Asselain B. Is obesity an independent prognosis factor in woman breast cancer? Breast Cancer Res Treat. 2008; 111: 329-342.

  22. Petrelli JM, Calle EE, Rodriguez C, Thun MJ. Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control. 2002; 13: 325-332.

  23. Ewertz M, Jensen MB, Gunnarsdottir KA, Hojris I, Jakobsen EH, Nielsen D et al. Effect of obesity on prognosis after early-stage breast cancer. J Clin Oncol. 2011; 29: 25-31.




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