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Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2020, Number 3

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Rev Latin Infect Pediatr 2020; 33 (3)

Early congenital syphilis, case series and anatomopathological description

Osorio-Guzmán M, Santos-Vázquez G, Torres-Muñoz D, González-Córdova GI, Moreno-Pizarro E, Heredia-Cimental DC

Language: Spanish
References: 16
Page: 149-155
PDF size: 289.41 Kb.


ABSTRACT

Introduction: Congenital syphilis is the systemic infection caused by Treponema pallidum acquired by the newborn, via the transplacental route of a mother suffering from syphilis during pregnancy. Fetal infection can occur at any time during pregnancy. Vertical transmission is most common during secondary syphilis. In Mexico the incidence is 2.9 cases per 100,000 newborns. The clinical picture is diverse. Material and methods: Being 50% female and the rest male, the average gestational age at 38 weeks, age of diagnosis of 5 cases was in the first week of life, in one case up to the 4th month. Regarding maternal characteristics, the average age was 22 years, 3 of them were drug addicts, 4 did not have prenatal control, the 2 who had it only attended 2 appointments. Only one was diagnosed with prenatal syphilis, and only one had antenatal treatment, but it was incomplete. All patients had desquamation and altered acute phase reactants, 5 had low birth weight and hepatosplenomegaly. Pneumonia Alba, bone alterations and in the hematic biometry were presented in 2 occasions each alteration. The VDRL (Venereal Disease Research Laboratory) was positive only in one patient in cerebrospinal fluid. Serum VDRL was positive in all cases with titres from 1:8 to 1:256, all were HIV negative. In all cases the treatment was crystalline penicillin G in 4 patients the dose of 50 IU/kg/dose, and in 2 of 300 IU/kg/dose, with duration of 10-14 days. Only one case died, the rest live. Conclusions: Congenital syphilis is a public health problem due to the morbidity and mortality for the newborn. In all our cases there was poor or no prenatal control.


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