2020, Number 276
<< Back Next >>
16 de abril 2020; 59 (276)
Anterior mediastinal choriocarcinoma in male patient
Soriano-Lorenzo J, Lima PM, Soriano GJL
Language: Spanish
References: 27
Page: 1-4
PDF size: 467.96 Kb.
ABSTRACT
Introduction: Choriocarcinoma is a malignant variety of non-seminomatous germ cell tumor. It is presented with more frequent in the chorionic epithelium of placenta and is very rare in men. The presentation in men is most common the testicles, being their extragonadal presentation very strange.
Case report: a 21 year-old man, he did not have any personal pathological previous case. He had been presenting a progressive health history of cough, dyspnea, expectoration and chest pain. The Computed Tomographic was performed and detected an anterior mediastinal tumor accompanied of high levels of Alpha-Fetoproteins and Beta-Human Chorionic Gonadotrophin. The treatment for extragonadal germ cell tumor was started but the patients died. The autopsy confirmed the diagnostic of anterior mediastinal choriocarcinoma.
Conclusion: In the presence of a patient with tumorous mass mediastinal is necessary to carry out an appropriate differential diagnosis by keeping in mind the clinical picture, imaging datas, and the location in the mediastinum.
REFERENCES
Molins L. Enfermedades del mediastino. En: Farreras-Valentí P y Rozman C, (Ed). Medicina Interna. 18va Ed. Barcelona: Editorial Elsevier; 2016. p. 756-759.
Castellanos D, Diaz P, Sepúvela J, Paz-Ares L, Cortés-Funes H. Tumores mediastínicos y Mesotelioma pleural. En: Cortés-Funes H y Colomer-Bosch R, (Ed). Tratado de Oncología Médica. Barcelona: Editorial Permanyer; 2009. p. 689-709.
BeauBeau V. Duwe, Daniel H. Sterman and Ali I. Musani. Mediastinal tumors. Chest. (internet) 2005 (citado 10 Sept 2019); 128; 2893-2909. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0012369215527153?via%3Dihub
Rahi R, Biswas M, Khanna R, Khanna AK. Extragonadal germ cell tumor. Ind J Surg. (internet) 2010 (citado 10 Sept 2019); 72:138-139. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452513/
Bush J, Seidel C, Zengerling F. Male extragonadal germ cell tumor. Oncol Res and Treat. (internet) 2016 (citado 10 Sept 2019); 39:140-144. Disponible en: https://www.karger.com/Article/FullText/444271
Couto WJ, Gross JL, Deheinzelin D, Naim R. Tumores de celulas germinativas primarios do mediastino. Rev Assoc Med Bras. (internet) 2006 (citado 10 Sept 2019); 52(3): 182-186. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302006000300020
Konheim JA, Israel JA, Delacroix SE. Klinefelter syndrome with poor risk extragonadal germ cell tumor. Urol Case Report. (internet) 2017 (citado 10 Sept 2019); 10: 1-3. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S2214-4420(16)30112-7
Völkl TM, Langer T, Aigner T, et al. Klinefelter syndrome and mediastinal germ cell tumor. Am J Med Gen. (internet) 2006 (citado 10 Sept 2019); 140A: 471-481. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.a.31103
Busch J, Seidel C and Zengerling F. Male extragonadal germ cell in the adults. Oncol Res Treat (internet) 2016 (citado 10 Sept 2019); 39:140–144. Disponible en: https://www.karger.com/Article/FullText/444271
Bokemeyer C, Nichols CR, Droz JP, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: Results from an international analysis. J Clin Oncol (internet) 2018 (citado 10 Sept 2019); 20: 1864–1873. Disponible en: https://ascopubs.org/doi/abs/10.1200/JCO.2002.07.062?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=jco
Tomaszek S, Wigle D, Keshavjee S, Fischer S. Thymomas: review of current clinical practice. Ann Thorac Surg. (internet) 2009 (citado 10 Sept 2019); 87(6): 1973–1980. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0003-4975(09)00011-3
Tsiaras SV, Safi LM, Ghoshhajra BB, Lindsay ME and Wood MJ. Case 39-2017: A 41-year-old woman with recurrent chest pain. N Engl J Med. (internet) 2017 (citado 10 Sept 2019); 377: 2475-84. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMcpc1707558?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Savage KJ. Primary mediastinal large B-cell lymphoma. The Oncol. (internet) 2016 (citado 10 Sept 2019); 11(23): 488-495. Disponible en: https://theoncologist.onlinelibrary.wiley.com/doi/full/10.1634/theoncologist.11-5-488
Boleti E, Johnson WM. Primary mediastinal B-cell lymphoma. HematolOncol. (internet) 2009 (citado 10 Sept 2019); 25:157-63. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/hon.818
Van Besien K, Kelta M, Bahaguna P. Primary mediastinal B-cell lymphoma: a review of pathology and management. J Clin Oncol. (internet) 2018 (citado 10 Sept 2019); 19:1855-64. Disponible en: https://ascopubs.org/doi/abs/10.1200/JCO.2001.19.6.1855?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=jco
Shipp MA, Aquino SL and Harris NL. Case 12-2005: A 30-Year-Old Woman with a Mediastinal Mass. N Eng J Med. (internet) 2015 (citado 10 Sept 2019); 352:1697-704. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMcpc059006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Rodríguez G, Rodríguez M, Arias D, Brea L, Infante C. Diagnóstico y tratamiento de nódulos de la glándula tiroides. MEDISAN. (internet) 2016 (citado 10 Sept 2019); 10 (1). Disponible en: https://www.redalyc.org/html/3684/368444986008/
Palermo-Garofalo C, Miranda ML, Martínez JH, Torres O, Gonzalez E. Evaluación clínica y ultrasonido tiroideo en pacientes adultos asintomáticos de la población puertorriqueña. Boletín (Asoc Med PR). (internet) 2011 (citado 10 Sept 2019); 103 (1). Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1728-59172011000300005
Albany C, Einhorn LH. Extragonadal germ cell tumors: Clinical presentation and management. Curr Opin Oncol. (internet) 2013 (citado 10 Sept 2019); 25: 261–265. Disponible en: https://insights.ovid.com/crossref?an=00001622-201305000-00009
Garcia H, Borrazas MC, Fermandez M. Teratoma mediastinal anterior. Rev Cub Med Mil. (internet) 2016 (citado 10 Sept 2019); 45 (2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572016000200012
Merkel PA, McCarty D, Sharma A and Stone JR. Case 31-2008: A 39-year-old man with chest pain, arthralgias, and a mediastinal mass. N Engl J Med (internet) 2018 (citado 10 Sept 2019); 359: 1603-14. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMcpc0805310?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Francischetti IM, Cajigas A, Suhrland M, Farinhas JM, Khader S. Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound-guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke. Diagnostic Cytopathology. (internet) 2017 (citado 10 Sept 2019); 45:738–743. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/dc.23719
Gilligan TD, Seidenfeld J, Basch EM, Einhorn LH, Fancher T, et al. American Society of Clinical Oncology: Clinical practice guideline on uses of serum tumor markers in adult males with germ cell tumors. J Clin Oncol. (internet) 2010 (citado 10 Sept 2019); 28(20): 3388-3404. Disponible en: https://ascopubs.org/doi/full/10.1200/JCO.2009.26.4481?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Makino T, Konaka H and Namiki M. Clinical features and treatment outcomes in patients with extragonadal germ cell tumors: a single-center experience. Anticancer Research. (internet) 2016 (citado 10 Sept 2019); 36: 313-318. Disponible en: http://ar.iiarjournals.org/content/36/1/313.long
Takahashi T and Kobayashi R. Choriocarcinoma syndrome after resection of primary pulmonary choriocarcinoma: report of a case. Surgical Case Reports. (internet) 2016 (citado 10 Sept 2019); 2: 122. Disponible en: https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-016-0227-5
Fukui N, Kohno Y, Ishioka JI, Fukuda H, Kageyama Y, Higashi Y. Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: The Saitama Cancer Center experience. Int J Clin Oncol. (internet) 2013 (citado 10 Sept 2019); 18: 731–734. Disponible en: https://link.springer.com/article/10.1007%2Fs10147-012-0436-
Tanaka Y, Okamura T, Nagai T, et al. A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy. Adv in Urol. (internet) 2017 (citado 10 Sept 2019); 6(3): 234-239. Disponible en: https://www.hindawi.com/journals/au/2017/1404610/