2019, Number 4
<< Back Next >>
Rev Cub Oftal 2019; 32 (4)
Influence of diabetes mellitus in the ocular surface
Cárdenas ML, Negrin-Caceres Y
Language: Spanish
References: 25
Page: 1-12
PDF size: 520.86 Kb.
ABSTRACT
Diabetes mellitus (DM) is one of the most common systemic diseases worldwide with an
increasing prevalence and a high mortality rate. Diabetic retinopathy is one of the leading causes of blindness in all the latitudes of the world. Although other eye diseases secondary to
diabetes also cause blindness, such influence on the ocular surface is poorly studied; however,
73.6% of type 2 diabetic patients suffer from corneal or ocular surface complications. A review
of the available updated bibliography in Spanish and English languages was carried out from
full texts and abstracts in databases such as PubMed, Ebsco, Google Scholar, and Scielo. In
addition, novel articles were consulted in prestigious specialized journals, with the aim of
providing updated information on the influence of diabetes on the ocular surface. Diabetes
mellitus has an adverse impact on the ocular surface. The severity of diabetic corneal
neuropathy correlates with diabetic peripheral neuropathy. The study of the ocular surface, as
well as the retina, is important for the optimal treatment of diabetes. Novel therapeutic options
have been introduced, but there are still many in the investigative phase for ocular surface
disorders associated with diabetes.
REFERENCES
Han SB, Yang HK, Hyon JY. Influence of diabetes mellitus on anterior segment of the eye. Clin Interv Aging. 2018;14:53-63. Doi:10.2147/CIA.S190713
Misra SL, Braatvedt GD, Patel DV. Impact of diabetes mellitus on the ocular surface: a review. Clin Exp Ophthalmol. 2016;44(4):278-88. Doi: 10.1111/ceo.12690
Ljubimov AV. Diabetic complications in the cornea. Vision Res. 2017;139:138-52. Doi: 10.1016/j.visres.2017.03.002
Calvo-Maroto AM, Pérez-Cambrodí RJ, Albarán-Diego C, Pons A, Cerviño A. Optical quality of the diabetic eye: a review. Eye (Lond). 2014;28:1271-80.
He F, Zhao Z, Liu Y, Lu L, Fu Y. Assessment of ocular surface damage during the course of type 2 diabetes mellitus. J Ophthalmol. 2018;15:1206808. Doi: 10.1155/2018/1206808
Bikbova G, Oshitari T, Baba T, Bikbov M, Yamamoto S. Diabetic corneal neuropathy: clinical perspectives. Clin Ophthalmol. 2018;12:981-7. Doi:10.2147/OPTH.S145266
Shih KC, Lam KS, Tong L. A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 2017;7(3):e251. Doi:10.1038/nutd.2017.4
Dan J, Zhou QJ, Xie LX. The research progress of relationship between advanced glycation end products and diabetic keratopathy. Zhonghua Yan Ke Za Zhi. 2018;54(6):475-80. Doi: 10.3760/cma.j.issn.0412-4081.2018.06.018
Bettahi I, Sun H, Gao N, et al. Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFβ3 expression contributes to the delay of epithelial wound healing in diabetic corneas. Diabetes. 2014;63(2):715-27. Doi:10.2337/db13-1260
Liu H, Sheng M, Liu Y, Wang P, Chen Y, Chen L, et al. Expression of SIRT1 and oxidative stress in diabetic dry eye. Int J Clin Exp Pathol. 2015;8:7644-53.
Yang AY, Chow J, Liu J. Corneal innervation and sensation: the eye and beyond. Yale J Biol Med. 2018;91(1):13-21.
Markoulli M, Flanagan J, Tummanapalli SS, et al. The impact of diabetes on corneal nerve morphology and ocular surface integrity. Ocul Surf. 2018;16(1):45-57. Doi: 10.1016/j.jtos.2017.10.006
Lv Y, Zhao S. What is the best strategy on detection of cornea neuropathy in people with diabetes? Recent advances in potential measurements. Diab Res Clin Pract. 2018;142:203-12. Doi: 10.1016/j.diabres.2018.03.015
Cruzat A, Qazi Y, Hamrah P. In Vivo confocal microscopy of corneal nerves in health and disease. Ocul Surf. 2017;15(1):15-47. Doi:10.1016/j.jtos.2016.09.004
Kalteniece A, Ferdousi M, Adam S, et al. Corneal confocal microscopy is a rapid reproducible ophthalmic technique for quantifying corneal nerve abnormalities. PLoS One. 2017;12(8):e0183040. Doi:10.1371/journal.pone.0183040
Bussan KA, Robertson DM. Contact lens wear and the diabetic corneal epithelium: A happy or disastrous marriage? J Diab Complicat. 2019;33(1):75-83. Doi: 10.1016/j.jdiacomp.2018.09.015
Kalteniece A, Ferdousi M, Petropoulos I, et al. Greater corneal nerve loss at the inferior whorl is related to the presence of diabetic neuropathy and painful diabetic neuropathy. Scientific Reports. 2018;(8):3283. Doi: 10.1038/s41598-018-21643-z
Deák EA, Szalai E, Tóth N, et al. Longitudinal changes in corneal cell and nerve fiber morphology in young patients with type 1 diabetes with and without diabetic retinopathy: a 2- year follow-up study. Invest Ophthalmol Vis Sci. 2019;60(2):830-7. Doi: 10.1167/iovs.18- 24516
Sitompul R. Corneal sensitivity as a potential marker of diabetic neuropathy. Acta Med Indones. 2017;49(2):166-72.
Misra SL, Craig JP, Patel DV, McGhee CN, Pradhan M, Ellyett K, et al. In vivo confocal microscopy of corneal nerves: an ocular biomarker for peripheral and cardiac autonomic neuropathy in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 2015;56:5060-5.
Gunay M, Celik G, Yildiz E, et al. Ocular Surface Characteristics in Diabetic Children. Curr Eye Res. 2016;41(12):1526-31.
Adam M, Balcı M, Bayhan HA, İnkaya AÇ, Uyar M, Gürdal C. Conjunctival Flora in Diabetic and Non diabetic Individuals. Turk J Ophthalmol. 2015;45(5):193-6. Doi:10.4274/tjo.33230
Bron AJ, de Paiva CS, Chauhan SK, et al. The ocular surface TFOS DEWS II pathophysiology report. Ocul Surf. 2017;15(3):438-510.
Shamsheer RP, Arunachalam C. A clinical study of meibomian gland dysfunction in patients with diabetes. Middle East Afr J Ophthalmol. 2015;22(4):462-6. Doi: 10.4103/0974- 9233.167827
Shimazaki J. Definition and diagnostic criteria of dry eye disease: historical overview and future directions. Invest Ophthalmol Vis Sci. 2018;59:7-12. Doi:10.1167/iovs.17-23475