2020, Number 2
Polymorphs of the SLC6A4 gene in young individuals with suicidal ideation
Briones BA, Barrientos SC
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Language: Spanish
References: 0
Page: 31-49
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ABSTRACT
The SLC6A4 gene encodes a serotonin transporter protein and has been used as the target of antidepressant medications due to its implications in the pathogenesis of depression and other affective disorders that have suicidal behavior as an indicator of severity. The presence of polymorphisms in its promoter region (5 ‐ HTTLPR) has been demonstrated, which consist of an insertion of 44 bp (long, L) or its elimination (short, S). Objective L was to determine the relationship between the presence of polymorphisms and S of the promoter of the SLC6A4 gene and suicidal ideation in order to be used as a predictive genetic marker for this type of disease and provide a more effective therapeutic management. Methodology: A sample of 30 young people divided into a case group and a control group was studied. From which DNA samples were obtained in blood and the regions corresponding to the polymorphisms of the SLC6A4 gene were amplified by the end-point PCR technique and the sequences were corroborated by Sanger-type sequencing.