medigraphic.com
ISSN 1561-3119 (Electronic)

2020, Number 1

<< Back Next >>

Rev Cubana Pediatr 2020; 92 (1)

Gut microbiota and obesity in childhood

Castañeda GC

Language: Spanish
References: 55
Page: 1-24
PDF size: 647.62 Kb.


ABSTRACT

Introduction: Obesity is linked to metabolic and systemic diseases, such as insulin resistance, diabetes mellitus type 2, non-alcoholic fatty liver disease, atherosclerosis and high blood pressure, through the production of positive energy balance by increasing calories intake in the diet and the decrease energy associated with low physical activity; being these events the main cause of obesity.
Objectives: To analyze the participation of the gut microbiota in obesity and the mechanisms involved in this process in mice, the proposed in humans and the role of modulation of the gut microbiota as a treatment.
Methods: Publications in English and Spanish on PubMed, Google Scholar, ScIELO from January 2005 to February 2019 were reviewed, and were used the terms: gut microbiota, obesity and modulation of gut microbiota.
Results: There were updated the criteria related to the gut microbiota and obesity, its increase and impact on pediatrics. The main experimental studies in mice and humans made during the decade 2001-2010 and events in the microbiome as pathogenic factor were reviewed. The mechanisms defined in the gut microbiota which participate in obesity were reviewed, as well as the arguments on modulation of the intestine to regulate the alterations produced in obesity.
Final considerations: It is shown the participation of the gut microbiota as a predisposing factor in the pathophysiology of obesity and its therapeutic modulation with various methods of biotherapy to reset the heterogeneity of the microbiome; among them are promising the use of prebiotics, probiotics, symbiotics and the transplantation of fecal microbiota.


REFERENCES

  1. Sun L, Ma L, Ma Y, Zhang F, Zhao C, Nin Y. Insights into the role of gut microbiota in obesity: Pathogenesis, mechanisms, and therapeutic perspectives. Protein Cell. 2018 [acceso 05/12/2018];9(5):397-403. doi: org/10.1007/s13238-018-0546-3. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960470

  2. Araneda G. Poniachik R, Jiménez A, Poniachik J. Microbiota e hígado graso: potencial terapéutico. Gastroenterol Latinoam. 2016 [acceso 05/01/2019];27(Supl 1):S47-S50. Disponible en: http://gastrolat.org/DOI/PDF/10.0716/gastrolat2016s100010.pdf

  3. Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 2016 [acceso 06/01/2019];535:376-381. doi: 10.1038/nature18646. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27409811

  4. Bashiardes S, Shapiro H, Rozin S, Shibolet O, Elinav E. Non-alcoholic fatty liver and the gut microbiota. Molecular Metabolism. 2016 [acceso 06/01/2019];3:1-13. doi: 10.1016/j.molmet.2016.06.003.eCollection 2016 Sep. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27617201

  5. Boursier J, Diehl AM. Non-alcoholic fatty liver disease and the gut microbiome. [review]. Clin Liver Dis. 2016;20:263-75. doi: 10.1016/j.cld.2015.10.012. Epub 2015 Dec 24.

  6. Emoto T, Yamashita T, Kobayashi T, Sasaki N, Hirota Y, Hayashi T, et al. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease. Heart Vess. 2017 [acceso 06/01/2019];32:39-46. doi: 10.1007/s00380-016-0841. Disponible en: -https://www.ncbi.nlm.nih.gov/pubmed/27125213

  7. Tilg H, Adolph TE, Gerner RR, Moschen AR. The intestinal microbiota in colorectal cancer. Cancer Cell. 2018;33:954-64. doi: 10.1016/j.ccell.2018.03.00.

  8. Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell. 2018;33:570-80. doi: 10.1016/j.ccell.2018.03.015 Review.

  9. McCann J, Rawls J, Seed P, Armstron S. The microbiome intestinal and childhood obesity. Curr Pediatric Report. 2017 [acceso 14/12/2018];5(3):150-5. doi: 10.1007/s40124-017-01409. Disponible en: https://slideheaven.com/the-intestinal-microbiome-and-childhood-obesity.html

  10. American Society for Microbiology. Gut microbiota of infants predicts obesity in children. Science Daily. 2018[acceso: 07/01/2019];23 October. Disponible en: https://www.sciencedaily.com/releases/2018/10/181023085640.htm

  11. Organización Mundial de la Salud. Obesidad y sobrepeso. Datos y cifras. Ginebra: OMS; 2018 [acceso 15/12/2018]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight

  12. Organización Mundial de la Salud. Obesidad y sobrepeso. Nota descriptiva. Ginebra: OMS; 2017 [acceso 14/12/2018]. Disponibleen: http://www.aps.who.int/mediacentre/ factsheetsfs311/es/index/html

  13. Organización Mundial de la Salud. Informe de la Comisión para acabar con la obesidad infantil. Preguntas frecuentes. Ginebra: OMS; 2016 [acceso 15/12/2018]. Disponible en: https://www.who.int/end-childhood-obesity/faq/es/

  14. Baothman OA, Zamzami MA, Taher I, Abubaker J, Abu-Farha M [review]. The role of gut microbiota in the development of obesity and diabetes.Lipids Health Dis. 2016 [acceso 06/01/2019];15:108. doi: 10.1186/s12944-016-0278-4. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912704/

  15. Castaner O, Goday A, Park YM, Lee -H, Magkos F, Shlow STE, et al. The Gut Microbiome profile in obesity: A systematic review. Int J Endocrinol. 2018 [acceso 07/01/2019];2018: Article ID 4095789. Disponible en: https://www.hindawi.com/journals/ije/2018/4095789/

  16. La Riva A, Lassandro C, Verduci E, Morace G, Borghi E, et al. La obesidad pediátrica se asocia con una microbiota intestinal alterada y cambios discordantes en las poblaciones de Firmicutes.Environ Microbiol. 2017;19:5-105.

  17. Castañeda C. Microbiota intestinal y salud infantil. Rev Cubana Pediatr. 2018 [acceso 05/01/2019];90(1):94-110. Disponible en: http://scielo.sld.cu/scielo.php?script= sci_arttext&pid=S0034-5312018000100010 18. Morán Ramos S, López BE, Villaruel R, Canizales S. Microbiota intestinal y obesidad infantil. Mensaje Bioquím. 2016; XL:167183.

  18. Shen TD. Diet and Gut Microbiota in Health and Disease. Nestlé Nutr Inst. 2017;88:117-126. doi: 10.1159/000455220. Epub 2017 Mar 2.

  19. Esquivel Flores M G. Microbiota intestinal: el universo que nos habita. Cuad Nut. 2017;40(3):107-14.

  20. Valenzuela A. Compartiendo conocimientos. Trasplante microbiota fecal y obesidad. Tema del Mes. Chile: Sociedad Chile de Obesidad; 2016.

  21. Borek C. Gut Microbiome and Its Potential Role in Obesity. J Restorativ Med. 2017 [acceso 14/01/2019];6(1):46-52. Disponible en: https://restorativemedicine.org/journal/gut-microbiome-potential-role-obesity/

  22. Arora T, Bäckhed F. The gut microbiota and metabolic disease: current understanding and future perspectives. J Intern Med. 2016. [acceso 12/01/2019]; 280:339-49]. doi: 10.1111/joim.12508. Disponible en: https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.12508

  23. Hollister EB, Riehle K, Luna RA, Weidler EM, Rubio-Gonzales M, Mistretta TA, et al. Structure and function of the healthy pre-adolescent pediatric gut microbiome. Microbiome. 2015 [acceso15/01/2019];3:36. doi: 10.1186/s40168-015-0101-x. Disponible en: https://scholars.houstonmethodist.org/en/publications/structure-and-function-of-the-healthy-preadolescent-pediatric-gut-microbiome(da3b0cdd-98c6-4f3d-b6d2-1f18939e025f).html

  24. Chen D, Yang Z, Chen X, Huanng Y, Yin B, Guo F. Effect of Lactobacillus Rhamnosusharytm1301 on the gut microbiota and lipid metabolism in rats fed a high-fat diet. J Microbiol Biotechnol. 2015 [acceso 24/01/2019];25:687-95. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25418480

  25. De Filipo C, Cavaleri D, Di Paola M, Romazzutti M, Poulet JB, Massart S, et al. Impact of diet in shaping gutmicrobiota revealed by a comparative study in children from Europe and rural Africa. Proc Natt Acad Sci U.S.A. 2010 [acceso 10/10/2019];107(33):14691-96. Disponible en: https://doi.org/10.1073/pnas.1005963107

  26. Zhang C, Li S, Yang L, Huang P, Li W, Wang S, et al. Structural modulation of gut microbiota in life-long caloric restricted mice. Nat Commun. 2013 [acceso 02/02/2019];42163. doi: 10.1038/ncomms3163. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/23860099

  27. Valsecchi C, Tagliacarne C, Castellazzi A. Gut microbiota and obesity. J Clin Gastroenterol. 2016 [acceso 12/12/2018];50:S157-58. doi: 10.1097/MCG.0000000000000715. Disponible en: https://journals.lww.com/jcge/Pages/articleviewer.aspx?year=2016&issue= 11001&article=00014&type=Fulltext

  28. Waldbaum C, Antelo P, Sordá J. Infección severa y complicada por Clostridium difficile resuelta con trasplante de microbiota. Acta Gastroenterol Latioam. 2017;47(3):211-15.

  29. Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome Throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;8:39. doi:10.1186/s13073-016-0294-z [acceso 18/01/2019]. Disponible en: www.ncbi.nlm.nih.gov/pmc/articles/PMC4831151/

  30. Chelakkot C, Ghim J, Ryu SH. Mechanisms regulating intestinal barrier Integrity an its pathological implications. Exp Mol Med. 2018;50(8):103. doi: 10.1038/s12276-018-0126-x.

  31. Castañeda C. Trasplante microbiota fecal. Rev Cubana Pediatr. 2019 [acceso 18/12/2019];91(3). Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/829/413

  32. Ley RE, Bäckhed F, Turnbaugh P, Lozapone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc. Natl. Acad Sci U.S.A. 2005;102:11070-75.

  33. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022-23.

  34. 35.Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity associated gut microbiome with increased capacity for energy harvest. Nature. 2006 [acceso 12/12/2018];444:1027-1031. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/17183312

  35. Ridaura VK, Faith JJ, Rey FE, Cheng JU, Duncan AE, Kau AL, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013 [acceso 12/12/2018];341:1241214. doi: 10.1126/science1241214. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/24009397

  36. Martin PP, Wang Y, Sprenger N, Yap IK, Lundsted T, Lek P, et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol. 2008;4:157.

  37. Li JV, Ashrafian H, Buette M, Kinross J, Sands C, le Roux CW, et al. Metabolic surgery profoundly influence gut microbial-host metabolic crosstalk. Gut. 2011;60:1214-23.

  38. Cho I, Yamanishi S, Cox L, Methe BA, Zavadil J, Li K, et al. Antibiotics in early life after the murine colonic microbiome and adiposity. Nature. 2012;30.621-626.

  39. Chambers ES, Preston T, Frost Y, Morrison DJ. Rol gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health. Curr Nutr Rep. 2018 [acceso 20/01/2019];7(4):198-206. doi: 10.1007/s13668-018-0248-8. Disponible en: https://doi.org/10.1007/s13668-018-0248-8

  40. Lau E, Carvalho D, Pina-Vaz C, Barbosa JA, Freitas P. Beyond gut microbiota. Understanding obesity and type 2 diabetes [abstract]. Hormones. 2015 [acceso 18/12/2018];14(3):358-69. doi: 10.14310/horm.2002.1571. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/26188221

  41. Porras D, Nistal E, Martínez-Flórez S, González-Gallego J, García-Mediavilla MV, Sánchez-Campos S. Intestinal Microbiota Modulation in Obesity-Related Non-alcoholic Fatty Liver Disease. Front Physiol. 2018 [acceso 25/01/2018];18(9):1813. doi: 10.3389/fphys.2018.01813. eCollection 2018. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30618824

  42. Castañeda C. Actualización en prebióticos. Rev Cubana Pediatr. 2018 [acceso 25/01/2019];90(4). Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/648/235

  43. Tarantino G, Finelli C. Systematic review on intervention with prebiotics/probiotics in patients with obesity‐related nonalcoholic fatty liver disease. Future Microbiol. 2015;10:889‐02. doi: 10.2217/fmb.15.13.

  44. Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Prebiotic reduces body fat and alters intestinal microbiota in children with overweight or obesity. Gastroenterology. 2017 [acceso 12/6/2018];153:711˗22. doi: 10.1053/j.gastro.2017.05.055. Epub 2017 Jun 5. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/28596023

  45. Fernandes R, do Rosario VA, Mocellin MC, Kuntz MGF, Trindade EBSM. Effects of inulin-type Fructans galacto-oligosacchrides and related symbiotics on inflammatory markers in adult patients with overweight or obesity: a systematic review. Clin Nutr. 2017 [acceso 06/01/2019];26:1197-2006. doi: 10.1016/j.clnu.2016.10.003. Epub 2016 Oct 8. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27771020

  46. Castañeda C. Probióticos Puesta al día. Rev Cubana Pediatr. 2018 [acceso 26/01/2019];90(2):286-98.Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/500/195

  47. Khalesi S, Bellissimo N, Vandelanotte C, Williams S, Stanley D, Irwin C. A review of probiotic supplementation in healthy adults: helpful or hype? Eur J Clin Nutr (EJCN). 2018 [acceso 28/01/2019];73:24-37. Disponible en: https://www.nature.com/articles/s41430-018-0135-9

  48. Wilson-Tang WH, Lazen SL. Probiotic therapy to attenuate weight gain and Trimethylamine-N-Oxide generation: A cautionary tale. Obesity. 2015 [acceso 12/12/2018];23(12):2321-22. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21250

  49. Orterberg KL, Boutagy NE, McMillan RP, Stevens JR, Frisard MI, Kavanaugh JW, et al. Probiotic supplementation attenuates increase in body mass and fat mass during high-fat diet in healthy young adults. Obesity. 2015. [acceso 12/12/2018];23:2364-70. doi: https://doi.org/10.1002/oby.21230. Disponible en: https://onlinelibrary.wiley.com/ doi/abs/10.1002/oby.21230

  50. Castañeda C. Microbiota intestinal, probióticos y prebióticos. Enfermer Investigat. 2017 [acceso 18/01/2019];2(4):156-160. doi: http://dx.doi.org/10.29033/ei.v2n4.2017.07.. Disponible en: https://www.researchgate.net/publication/322124132Microbiota_intestinalprobioticos_y_prebioticos

  51. Beserra BT, Fernandes R, do Rosario VA, Mocellin MC, Kuntz MG, Trindade EB. A systematic review and meta-analysis of the prebiotic and synbiotic effects on glycemic, insulin concentration and lipid parameters in adult patients with overweight or obesity. Clin Nutr. 2015 [acceso 12/12/2018];34:845-58. doi: 10.1016/j.clnu.2014.10.004. Epub 2014 Oct 20. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/25456608

  52. Gupta S, Allen-Vercoe E, Pewtrrof EO. Fecal microbiota trasplantación: in perspective. Therap Adv Gastroenterol. 2016 [acceso 18/01/2019];9(2):229-232. doi:10.1172/175628X15607414. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749851/

  53. World Health Organization. Global Health Observator (GHO) data. Overweight and obesity. 2018 [acceso 26/01/2019]. Disponible en:https://www.who.int/gho/ncd/riskfactors/overweight_text/en/

  54. Willet W, Rockström J, Loken B, Springmann M, Lang T, Vermeculen S, et al. Food and the anthroprocene: the EAT-Lancet Commission on healthy diet from sustainable foods systems. Lancet Commissions. 2019. [acceso 20/02/2019];393(10170):447-92. doi: https://doi.org/10.1016/S0140-6736(18)31788-4. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31788-4/fulltext

  55. Paun A, Yau C, Meshkibaf S, Meskhibaf MG, Marandi L, Mortin-Toth S, et al. Association of HLA-dependent islet autoimmunity with systematic antibody to intestinal commensal bacteria in children. Sci Immunol. 2019;4(32):eaau8125. doi: 10.1126/sciimmunol.aau8125.




2020     |     www.medigraphic.com