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Medicina & Laboratorio

2017, Number 05-06

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Medicina & Laboratorio 2017; 23 (05-06)

Association of adiponectin and tumor necrosis factor-alpha (TNF-α) levels with albuminuria in patients with type 2 diabetes mellitus

Sierra-Castrillo J, Gómez-Rave LJ

Language: Spanish
References: 53
Page: 257-270
PDF size: 509.27 Kb.


ABSTRACT

Type 2 Diabetes mellitus is a metabolic chronic disease, which if it is not properly controlled produces a progressive kidney damage causing diabetic nephropathy. It is also highly associated with a chronic inflammatory state, related to adipocytokines (IL-6, TNF-α, leptin, adiponectin) secretion which are involved in metabolic homeostasis and crucial in both regulating the atherogenic process as in insulin resistance. Objective: To relate the behavior of adiponectin and TNF-α levels with albuminuria in patients with type 2 diabetes mellitus. Materials and methods: The research was based on a descriptive cross-sectional model with a study population composed by patients admitted to University Hospital Erasmo Meoz (Cucuta, Colombia). According to previously established selection criteria, two analysis groups were conformed; patients diagnosed with type 2 diabetes mellitus and albuminuria ›30 mg/L (n = 24), and a control group without the above conditions (n = 20). Results: The results revealed that there is a positive and statistically significant correlation between TNF-α concentration and albuminuria (p ‹0.03). It was observed that between TNF-α and adiponectin levels there are no apparently correlation (p› 0.05). Conclusions: although there are no significant differences between adiponectin and TNF-α levels, TNF-α could be exploited as an early markers for kidney damage or help designing of progression estimators of injury in patients with diabetes type 2.


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