Effect of pH nasal ionized saline solution on pulmonary function and respiratory infections of asthmatic children

Eduardo Antonio Lara-Pérez; Virgen-Ortega, Cesar; Félix Guillermo  Márquez-Celedonio; Josué Elí Villegas-Domínguez; Crespo-Cortés, Celia Nohemí

2020, Number 2

<< Back Next >>

Rev Mex Pediatr 2020; 87 (2)

Effect of pH nasal ionized saline solution on pulmonary function and respiratory infections of asthmatic children

Lara-Pérez EA, Virgen-Ortega C, Márquez-Celedonio FG, Villegas-Domínguez JE, Crespo-Cortés CN

Full text

How to cite this article

10.35366/94167

Language: Spanish
References: 20
Page: 46-50
PDF size: 257.47 Kb.

ABSTRACT

Objective: To determine the effect of administration of nasal ionized saline solution on nasal maximum inspiratory flow (NMIF), maximum expiratory flow (MEF) and frequency of upper respiratory tract infections (URTI) in asthmatic children. Material and methods: Quasi-experimental study, evaluating the evolution, before and after, of patients with poorly controlled asthma and without rhinitis. During four months of treatment with nasal ionized saline, the NMIF, MEF and the frequency of URTI were evaluated. Statistical analysis: χ² with Yates correction, Mann-Whitney U, Wilcoxon and Friedman. Results: Eighty asthmatic children aged 8.7 ± 2.1 years were included. NMIF of 58.4 ± 19.3 Lpm at baseline and 104.7 ± 29.2 at four months (p ‹0.05), baseline MEF was 192.7 ± 58.7 and 222.3 ± 67.0 Lpm at the end of follow-up (p ‹0.05). URTI frequency decreased progressively, 88.8% in the first month to any case in the fourth month (p ‹0.05).Conclusions: Ionized nasal saline in asthmatics without a rhinitis appears to improve FIMN, FEM, and ITRS frequency, however, randomized clinical trials are required to demonstrate its effectiveness.

REFERENCES

Pearce N, Aït-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, et al Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2007; 62: 758-766.
Lai CKW, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, the ISAAC Phase Three Study Group. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2009; 64: 476-483.
Kim JL, Brisman J, Al Äberg M, Forslund HB, Winkvist A, Torén K. Trends in the prevalence of asthma, rhinitis, and eczema in 15-year-old adolescents over an 8-year period. Respiratory Medicine. 2014; 108: 701-708.
Lara-Pérez EA. Prevalencia del asma infantil al nivel del mar. Rev Alerg Asma e Inmunol Pediatr. 2001; 10(3): 88-92.
Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017.
Evans CM, Kim K, Tuvim MJ, Dickey BF. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm M. 2009; 15(1): 4-11.
Chiron R, Vachier I, Khanbabaee G, Molinari N, Varrin M, Godard P, Chanez P. Impact of rhinitis on asthma control in children: association with FeNO. J Asthma. 2010; 47: 604-608.
Kariyawasam HH, Rotiroti G. Allergic rhinitis, chronic rhinosinusitis and asthma: unravelling a complex relationship. Curr Opin Otolaryngol Head Neck Surg. 2013; 21: 79-86.
De Oliveira TB, Klering EA, da Veiga ABG. Is recurrent respiratory infection associated with allergic respiratory disease? J Asthma. 2018; 13: 1-7.
Pite H, Pereira AM, Morais-Almeida M, Nunes C, Bousquet J, Fonseca JA. Prevalence of asthma and its association with rhinitis in the elderly. Respir Med. 2014; 108: 1117-1126.
Luna M de F, Fisher GB, Luna JR, Silva MG, Almeida PC, Chiesa D. Prevalence of rhinitis among 6 and 7-year old students in Fortaleza. Rev Assoc Med Bras. 2014; 60: 357-64.
García-García ML, Calvo C, Ruiz S, Pozo F, Del Pozo V, Remedios L et al. Role of viral coinfections in asthma development. PloS One. 2017; 12(12): e0189083.
Moeller A, Carlsen KH, Sly PD, Baraldi E, Piacentini G, Pavord I et al. Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation. Eur Respir Rev. 2015; 24: 204-215.
Mohan S, Fuller JC, Ford SF, Lindsay LW. Diagnostic and therapeutic management of nasal airway obstruction: advances in diagnosis and treatment. JAMA Facial Plast Surg. 2018; 20(5): 409-418.
Pite H, Pimenta L, Henriques AC, Marques I, Camarinha C, Laurenco AV et al. Lower airway flow influences peak nasal inspiratory flow in school-aged children. Rhinology. 2018; 56(3): 288-296.
Choby GW. Pharmacotherapy for the treatment of asthma: current treatment options and future directions. Int Forum Allergy Rhinol. 2015; 5(S1): S35-S40.
Hermelingmeier KE, Weber RK, Hellmich M, Heubach CP, Mösges R. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2012; 26(5): 119-125.
Cabello-Gutiérrez C, Rosete-Olvera P, Manjarrez-Zavala ME. Efecto de una solución electrolizada de superoxidación con pH neutro sobre la infección del virus de influenza A en células MDCK. Rev Inst Nal Enf Resp Mex. 2009; 22: 280-287.
Medina-Tamayo J, Sánchez-Miranda E, Belleza-Tapia H, Ambriz X, Cid ME, González-Espinosa D, Gutiérrez SS, González-Espinosa C. Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells. Int Immunopharmacol. 2007; 7(8): 1013-1024.
Lara-Pérez EA. Peak expiratory flow at sea level. Int Pediatr. 2001; 16: 89-93.