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2019, Number 4

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Rev Cubana Farm 2019; 52 (4)

Hydrophilic-lipophilic balance of chitosan derived from lobster chitin (Panulirusargus) using non-ionic surfactants

de la Paz Martín-Viaña N, Fernández CM, Pérez RD, La Rosa KY, Nogueira MA, García PO

Language: Spanish
References: 26
Page: 1-13
PDF size: 737.89 Kb.


ABSTRACT

Introduction: An essential parameter for an optimum formulation of emulsions is the value of the hydrophilic- lipophilic balance that has the emulsifying agent. Objective: To determine by the Griffin´s method the value of the hydrophilic- lipophilic balance of chitosan derived from lobster chitin in oil-in-water emulsions. Methods: There were developed oil-in-water emulsions with a 3 % of emulsifying mixture composed by the biopolymer and three types of polysorbate in different proportions; there were considered appropriate those with lower volume of aqueous phase separated after 14 days. Three emulsions were selected using polysorbate 80/chitosan in relation 30:70, 20:80 and 10:90; and it was found that with the increase of the chitosan concentration increased the stability of the system. The emulsion selected (E9) was assessed during 45 days in different thermal conditions. Results: From the 48 hours and until the end of study time, the emulsions containing an 80 %, 90 % and 100 % of the biopolymer of the total mixture of emulsifier remained stable and the value of hydrophilic- lipophilic balance of chitosan derived from lobster chitin was between 11 and 12. When increasing the concentration of chitosan the visual appearance was improving, the tension on the oil-water interface decreased, while the viscosity of the continuous phase and the emulsion stability increased. Conclusions: The emulsions prepared with chitosan and polysorbate 80, as an emulsifying mixture, showed greater stability with the decrease of the interfacial tension between the phases and the increased viscosity of the continuous phase to increase the concentration of the biopolymer being the main mechanism of stabilization of polymers, which will allow the use of chitosan derived from lobster chitin as stabilizer of dispersed systems for pharmaceutical use.


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