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Medicina & Laboratorio

2013, Number 03-04

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Medicina & Laboratorio 2013; 19 (03-04)

In situ breast cancer: an update

Gallego NGA, Velázquez VJ

Language: Spanish
References: 121
Page: 127-160
PDF size: 1275.31 Kb.


ABSTRACT

Carcinoma in situ of the breast is the first morphologically recognizable stage of breast cancer; it can progress to invasive disease; however, the precise rate of progression to invasive cancer is yet unknown. As ductal carcinoma in situ is a predictor of invasive ductal carcinoma, the decision-making process for treatment should be achieved with the patient. Currently, there are particular indications on which cases require conservative treatment and which require a radical treatment; nevertheless, each case must be considered independently. Regarding lobular carcinoma in situ, it is only considered a risk factor to develop invasive cancer, many of the patients do not need treatment and a close followup is suggested. In this review article, an update in signs and symptoms of ductal carcinoma in situ and lobular carcinoma in situ is included, as well as an update of their genetic abnormalities, diagnosis, prognosis, treatment and follow-up. In addition, an update in Paget disease is included.


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