medigraphic.com
ISSN 2500-7106 (Electronic)
ISSN 0123-2576 (Print)
Medicina & Laboratorio

2012, Number 05-06

<< Back Next >>

Medicina & Laboratorio 2012; 18 (05-06)

Prevalence of hemoglobinopathy S and hematological profile of individuals with malaria, Quibdó-Chocó, 2011

Silva SEX, Estupiñán ASP, Valencia MY, Pérez ER, Bejarano MZ, Cardona AJA

Language: Spanish
References: 55
Page: 239-251
PDF size: 453.62 Kb.


ABSTRACT

Introduction: malaria is a serious public health issue worldwide, especially in tropical countries; it is believed that hemoglobin S could protect against severe malaria. Objective: to determine the prevalence of hemoglobin S and assess the hematological profile of individuals with malaria, in Quibdó-Chocó. Materials and methods: cross-sectional study of 177 patients with malaria. The primary source of information was based on a structured survey, determination of the complete blood count, malaria diagnosis, a sickle cell test, and a hemoglobin electrophoresis to identify hemoglobin S. The measures of frequency and summary, the confidence intervals for proportions and the tests of parametric and nonparametric statistics were calculated. Results: 59% of the cases were positive for Plasmodium falciparum malaria, 35% for Plasmodium vivax malaria and 6% for mixed malaria; the prevalence of anemia was 52% and the hemoglobinopathy S prevalence was 1,1%. Furthermore, statistical differences in the prevalence of anemia were found according to race, sex, and age, whereas the frequency of anemia did not show differences in the analysis in relation to parasite density and the type of malaria infection. Conclusion: for this population the prevalence of hemoglobin S was lower than expected. However, the prevalence of anemia was very high, which shows a high risk for individual health and for quality of life in general.


REFERENCES

  1. Schechter AN. Hemoglobin research and the origins of molecular medicine. Blood 2008; 112: 3927-3938.

  2. Ruiz-Argüellez G. Fundamentos de hematología (ed 3rd). México: Editorial Medica Internacional; 2003.

  3. Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 2008; 86: 480-487.

  4. Alexy T, Sangkatumvong S, Connes P, Pais E, Tripette J, Barthelemy JC, et al. Sickle cell disease: selected aspects of pathophysiology. Clin Hemorheol Microcirc 2010; 44: 155-166.

  5. Wethers DL. Sickle cell disease in childhood: Part I. Laboratory diagnosis, pathophysiology and health maintenance. Am Fam Physician 2000; 62: 1013- 1020.

  6. Wurie AT, Wurie IM, Gevao SM, Robbin-Coker DJ. The prevalence of sickle cell trait in Sierra Leone. A laboratory profile. West Afr J Med 1996; 15: 201- 203.

  7. Diallo D, Tchernia G. Sickle cell disease in Africa. Curr Opin Hematol 2002; 9: 111-116.

  8. Taylor SM, Parobek CM, Fairhurst RM. Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12: 457-468.

  9. Williams TN, Mwangi TW, Roberts DJ, Alexander ND, Weatherall DJ, Wambua S, et al. An immune basis for malaria protection by the sickle cell trait. PLoS Med 2005; 2: e128.

  10. Flint J, Harding RM, Boyce AJ, Clegg JB. The population genetics of the haemoglobinopathies. Baillieres Clin Haematol 1998; 11: 1-51.

  11. Moyano M, Méndez F. Defectos eritrocíticos y densidad de la parasitemia en pacientes con malaria por Plasmodium falciparum en Buenaventura, Colombia. Rev Panam Salud Publica 2005; 18: 25-32.

  12. Bonet J. ¿Por qué es pobre el Chocó? Documentos de trabajo sobre economía regional. Banco de la República. 2007. Disponible en: http://www.banrep.gov. co/documentos/publicaciones/regional/documentos/ DTSER-90.pdf Consultado en noviembre de 2011.

  13. Ochoa J, Osorio L. Epidemiología de malaria urbana en Quibdó, Chocó. Biomédica 2006; 26: 278-285.

  14. Padilla-Rodriguez JC, Álvarez-Uribe G, Montoya- Araujo R, Chaparro-Narvaez PC, Herrera-Valencia SH. Epidemiology and control of malaria in Colombia. Mem Inst Oswaldo Cruz 2011; 106 Suppl 1: 114-122.

  15. Antinori S, Galimberti L, Milazzo L, Corbellino M. Biology of human malaria plasmodia including Plasmodium knowlesi. Mediterr J Hematol Infect Dis 2012; 4: e2012013.

  16. Sabbatani S, Fiorino S, Manfredi R. The emerging of the fifth malaria parasite (Plasmodium knowlesi): a public health concern? Braz J Infect Dis 2010; 14: 299-309.

  17. Trampuz A, Jereb M, Muzlovic I, Prabhu RM. Clinical review: Severe malaria. Crit Care 2003; 7: 315- 323.

  18. Restrepo A, Díaz F, Estrada S, Franco L, Jaramillo J, Maestre A, et al. Microbiología de las infecciones humanas. Medellín: Fondo editorial CIB; 2007.

  19. Casals-Pascual C, Kai O, Cheung JO, Williams S, Lowe B, Nyanoti M, et al. Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood 2006; 108: 2569-2577.

  20. Perkins DJ, Were T, Davenport GC, Kempaiah P, Hittner JB, Ong’echa JM. Severe malarial anemia: innate immunity and pathogenesis. Int J Biol Sci 2011; 7: 1427-1442.

  21. Robson KJ, Weatherall DJ. Malarial anemia and STAT6. Haematologica 2009; 94: 157-159.

  22. Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 2002; 119: 839- 847.

  23. Carmona-Fonseca J. La malaria en Colombia, Antioquia y las zonas de Urabá y Bajo Cauca: panorama para interpretar la falla terapéutica antimalárica. Parte 1. Iatreia 2003; 16: 299-318.

  24. World Health Organization. World malaria report 2011. Disponible en: http://www.who.int/malaria/ world_malaria_report_2011/WMR2011_noprofiles_ lowres.pdf. Consultado en junio de 2012. Switzerland; 2011.

  25. World Health Organization. World malaria report 2009. Disponible en: http://who.int/malaria/world_ malaria_report_2009/mal2009_summary_and_keypoints. pdf. Consultado en junio de 2012.

  26. WHO Global Malaria Programme. World malaria report 2010. Disponible en: http://www.ncbi.nlm.nih. gov/pmc/articles/PMC2647473/pdf/06-036673.pdf Consultado en junio de 2012. 2010.

  27. Alger J. Densidad parasitaria en malaria: métodos de determinación y su interpretación. Rev Med Hond 2001; 69: 118-120.

  28. Silva JR, Malambo D, Silva DF, Fals E, Fals O. Tamizaje de hemoglobinopatías en muestra de la población infantil de Cartagena. Pediatría (Bogotá) 1998; 33: 86-89.

  29. Aluoch JR. Higher resistance to Plasmodium falciparum infection in patients with homozygous sickle cell disease in western Kenya. Trop Med Int Health 1997; 2: 568-571.

  30. Espinel A, Valenzuela N. Adaptaciones genéticas a la malaria en poblaciones afroaborígenes del pacífico colombiano. Rev Antropol 1991; 7: 116-128.

  31. Vega R, Acosta N, Martínez J, Arrieta R, Estupiñán Z, Fonseca Z, et al. Análisis de disparidades por anemia nutricional en Colombia, 2005. Gerenc Polit Salud 2008; 7: 46-76.

  32. Haldar K, Mohandas N. Malaria, erythrocytic infection, and anemia. Hematology Am Soc Hematol Educ Program 2009: 87-93.

  33. Martínez R, Fernández A. Desnutrición infantil en América Latina y el Caribe. Desafíos. Boletín de la infancia y adolescencia sobre el avance de los objetivos de desarrollo del Milenio. División de Desarrollo Social de la CEPAL. Desafíos; 2006 4-9.

  34. Smith H, Dekaminsky R, Niwas S, Soto R, Jolly P. Prevalence and intensity of infections of Ascaris lumbricoides and Trichuris trichiura and associated socio-demographic variables in four rural Honduran communities. Mem Inst Oswaldo Cruz 2001; 96: 303- 314.

  35. Mansi MP, Dickson M, Rodríguez-Morales AJ. Influencia de la parasitemia sobre los valores de hemoglobina y anemia en niños con malaria por Plasmodium falciparum no complicada: experiencia en un hospital de Tanzania. Rev Perú Med Exp Salud Publica 2007; 24: 27-34.

  36. Price RN, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen L, ter Kuile F, et al. Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg 2001; 65: 614-622.

  37. Sowunmi A, Gbotosho GO, Happi CT, Fateye BA. Factors contributing to anaemia after uncomplicated Plasmodium falciparum malaria in children. Acta Trop 2010; 113: 155-161.

  38. Lathia TB, Joshi R. Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? Indian J Med Sci 2004; 58: 239- 244.

  39. Oh MD, Shin H, Shin D, Kim U, Lee S, Kim N, et al. Clinical features of vivax malaria. Am J Trop Med Hyg 2001; 65: 143-146.

  40. Taylor WR, Widjaja H, Basri H, Ohrt C, Taufik T, Tjitra E, et al. Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria. Malar J 2008; 7: 259.

  41. Jain M, Kaur M. Comparative study of microscopic detection methods and haematological changes in malaria. Indian J Pathol Microbiol 2005; 48: 464-467.

  42. Richards MW, Behrens RH, Doherty JF. Short report: hematologic changes in acute, imported Plasmodium falciparum malaria. Am J Trop Med Hyg 1998; 59: 859.

  43. McKenzie FE, Prudhomme WA, Magill AJ, Forney JR, Permpanich B, Lucas C, et al. White blood cell counts and malaria. J Infect Dis 2005; 192: 323-330.

  44. Gerardin P, Rogier C, Ka AS, Jouvencel P, Brousse V, Imbert P. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 2002; 66: 686-691.

  45. Kaushik JS, Gomber S, Dewan P. Clinical and epidemiological profiles of severe malaria in children from Delhi, India. J Health Popul Nutr 2012; 30: 113- 116.

  46. Makkar RP, Mukhopadhyay S, Monga A, Gupta AK. Plasmodium vivax malaria presenting with severe thrombocytopenia. Braz J Infect Dis 2002; 6: 263- 265.

  47. Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M. Anemia and thrombocytopenia in children with Plasmodium vivax malaria. J Trop Pediatr 2006; 52: 49-51.

  48. Saravu K, Docherla M, Vasudev A, Shastry BA. Thrombocytopenia in vivax and falciparum malaria: an observational study of 131 patients in Karnataka, India. Ann Trop Med Parasitol 2011; 105: 593-598.

  49. González B, Rodulfo H, de Donato M, Berrizbeitia M, Gómez C, González L. Variaciones hematológicas en pacientes con malaria causada por Plasmodium vivax antes, durante y después del tratamiento. Invest clín 2009; 50: 187-201.

  50. Kumar A, Shashirekha. Thrombocytopenia--an indicator of acute vivax malaria. Indian J Pathol Microbiol 2006; 49: 505-508.

  51. Lacerda MV, Mourao MP, Coelho HC, Santos JB. Thrombocytopenia in malaria: who cares? Mem Inst Oswaldo Cruz 2011; 106 Suppl 1: 52-63.

  52. Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, et al. Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemost 2004; 91: 553- 557.

  53. Marques HO, Alexandre MAA, Oliveira VM, Marreira L, Lacerda MVG, Alecrim MGC, et al. Hemostatic changes in patients with malaria. Annals of the XX Congress of the International Society on Thrombosis and Hemostasis, Sydney (Australia). J Thromb Haemost 2005; 3: 1452.

  54. de Mast Q, de Groot PG, van Heerde WL, Roestenberg M, van Velzen JF, Verbruggen B, et al. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol 2010; 151: 495-503.

  55. de Mast Q, Groot E, Lenting PJ, de Groot PG, Mc- Call M, Sauerwein RW, et al. Thrombocytopenia and release of activated von Willebrand Factor during early Plasmodium falciparum malaria. J Infect Dis 2007; 196: 622-628.




2020     |     www.medigraphic.com