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Federación Mexicana de Ginecología y Obstetricia, A.C.

2020, Number 05

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Ginecol Obstet Mex 2020; 88 (05)

Hypothyroidism associated with infertility in women in reproductive age

Jiménez-Ibañez LC, Conde-Gutiérrez YS, Torres-Trejo JA

Language: Spanish
References: 39
Page: 321-329
PDF size: 221.47 Kb.


ABSTRACT

Objective: To review the most recent bibliography to assess and synthesize the most important aspects in relation to the repercussions of hypothyroidism and its association with infertility in women of reproductive age.
Methodology: Documentary research study carried out based on the search in PubMed and Google Scholar; from the years 1993 to 2018 with the keywords: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, pregnancy loss, abortion and pregnancy in Spanish and English and retrospective study in textbooks.
Results: 39 documents were included, selecting the ones with the highest scientific and epidemiological relevance. Hypothyroidism affects women of reproductive age with a prevalence of 0.4-0.5% for the obvious and 2-8% for the subclinical, the latter can result in female infertility and poor reproductive results.
Conclusion: Hypothyroidism is a pathology that affects women, with a higher incidence in the fertile stage. A timely diagnosis and treatment improve the prognosis of fertility, pregnancy and life of the newborn.


REFERENCES

  1. Zárate A, et al. Enfermedad tiroidea: un tema de revisión constante por el ginecólogo, por su frecuencia en las mujeres. Ginecol Obstet Mex 2009;78(1):96-102.

  2. Organización Mundial de la Salud. Recomendaciones de la OMS sobre atención prenatal para una experiencia positiva del embarazo. 2018 https://iris.paho.org/bitstream/ handle/10665.2/49550/9789275320334_spa.pdf?ua=1

  3. Brugo-Olmedo S, et al. Definición y causas de la infertilidad. Rev. Colomb. Obstet. Ginecol. 2003;54(4):227-48.

  4. Remohi J, et al. Manual práctico de esterilidad y reproduccion humana. Aspectos clínicos. México: Editorial Médica Panamericana, 2018 (1): 5-14.

  5. Vite Vargas J, et al. Análisis epidemiológico de la infertilidad en una población mexicana. Ginecol Obstet Mex 2005; 73: 360-4.

  6. Mateo-Sánez HA, et al. Hipotiroidismo e infertilidad femenina. Rev Mex Reprod 2012; 5 (1): 3-6.

  7. Sadler OW. Embriología médica. Filadelfia: Wolters Kluwer, 2012; 12 (17): 274.

  8. Gratacós E, et al. Medicina Fetal. Barcelona: Editorial Médica Panamericana, 2007; 12 (11): 587.

  9. Poppe K, et al. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008; 4 (7): 394-405. doi: 10.1038/ncpendmet0846

  10. Gómez-Meléndez GA, et al. Hipotiroidismo. Med Int Mex 2010; 26 (5): 462-471.

  11. McGrogan A, et al. The incidence of autoimmune thyroid disease: a systematic review of the literature. Clin Endocrinol (Oxf). 2008 ;69(5):687-96. doi: 10.1111/j.1365- 2265.2008.03338.x

  12. Cooper DS, et al. The thyroid gland. In: Gardner DG, Shoback D, editors. Greenspan’s basic and clinical endocrinology. 8va.ed. New York: McGraw-Hill Companies, 2007;244.

  13. Inzucchi SE, et al. Glándula tiroides y reproducción. En: Yen SSC, Jaffe Rb, Barbieri RL, editores. Endocrinología de la reproducción: fisiología, fisiopatología y manejo clínico. 4a ed. Buenos Aires: Editorial Médica Panamericana, 2001; 440-64.

  14. Weghofer A, et al. What affects functional ovarian reserve, thyroid function or thyroid autoimmunity? Reprod Biol Endocrinol. 2016; 14: 26. doi 10.1186/s12958-016-0162-0

  15. Korevaar, Tim, et al. The association of thyroid function and autoimmunity with ovarian reserve in women seeking infertility care. Thyroid. 2018; 28 (10): 1349-58. doi: 10.1089/ thy.2017.0582

  16. Poppe K, et al. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008; 4 (7): 394-405. doi: 10.1038/ncpendmet0846

  17. Hollowell JG, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002; 87 (2): 489-99. doi:10.1210/ jcem.87.2.8182.

  18. Krassas GE, et al. Disturbances of menstruation in hypothyroidism. Clin Endocrinol (Oxf) 1999; 50 (5): 655-9. doi:10.1046/j.1365-2265.1999.00719.x

  19. Ansell JE. The Blood in Hypothyroidism. In: Braverman LE, Utiger RD, editors, Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 7th ed. Philadelphia: Lippincott-Raven, 1996(a): 821-25. [Google Scholar].

  20. Wakim AN, et al. Thyroid hormones in human follicular fluid and thyroid hormone receptors in human granulosa cells. Fertil Steril. 1993; 59 (6): 1187-90. doi:10.1016/ s0015-0282(16)55974-3

  21. Cramer DW, et al. Serum prolactin and TSH in an in vitro population: is there a link between fertilization an thyroid function? J Assist Reprod Genet. 2003; 20 (6): 210-5. doi:10.1023/a:1024151210536

  22. Meng L, et al. Dietary-Induced Chronic Hypothyroidism Negatively Affects Rat Follicular Development and Ovulation Rate and Is Associated with Oxidative Stress1. Biol Reprod. 2016; 94 (4): 90. doi: 10.1095/biolreprod.115.136515

  23. Practice Committee of the American Society for Reproductive Medicine. Subclinical hypothyroidism in the infertile female population: a guideline. Fertil Steril. 2015; 104 (3): 545-53. doi: 10.1016/j.fertnstert.2015.05.028

  24. Rodríguez ND, et al. Yodo y gestación. Rev Esp Endocrinol Pediatr 2016; 7 Weetman AP. Thyroid function effects on mother and baby unraveled. Nat Rev Endocrinol. 2011; 6; 8 (2): 69-70. doi: 10.1038/nrendo.2011.217

  25. Weetman AP . Thyroid disease in pregnancy in 2011: Thyroid function--effects on mother and baby unraveled. Nat Rev Endocrinol. 2011; 8 (2): 69-70. doi: 10.1038/ nrendo.2011.217

  26. Luton D, et al. Management of Graves’ Disease during Pregnancy: The Key Role of Fetal Thyroid Gland Monitoring. J Clin Endocrinol Metab. 2005; 90 (11): 6093-98. doi: 10.1210/jc.2004-2555

  27. Pérez-Unanua MP, et al. Manejo de la patología tiroidea en atención primaria I. Cribado de patología tiroidea. Hipotiroidismo. SEMERGEN 2008; 34 (9): 450-54. doi. org/10.1016/S1138-3593(08)75204-3

  28. American Thyroid Association.Hipotiroidismo; 2017. http:// www.thyroid.org/wpcontent/uploads/patients/brochures/ espanol/hipotiroidismo.pdf.

  29. UK Guidelines for the Use of Thyroid Function Test. United Kingdom; 2006. Disponible en http://www.acb.org.uk/ docs/TFTguidelinefinal.pdf.

  30. Biondi B, et al. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008; 29 (1): 76-131. doi:10.1210/ er.2006-0043

  31. Stagnaro-Green A, et al. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. Thyroid. 2011; 21 (10): 1081-125. doi: 10.1089/thy.2011.0087

  32. Fatourechi V. Subclinical hypothyroidism: an update for primary care physicians. Mayo Clin Proc. 2009; 84 (1): 65- 71. doi: 10.1016/S0025-6196(11)60809-4

  33. Baskin HJ, et al. American Association of Clinical Endocrinologists (AACE) medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract 2002; 8 (6):457-69.

  34. Okosieme O, et al. Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee. Clin Endocrinol (Oxf). 2016; 84 (6): 799-808. doi: 10.1111/cen.12824

  35. Pearce S, et al. 2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J. 2013 Dec; 2 (4): 215-28. doi: 10.1159/000356507

  36. Brenta G, et al. Task Force on Hypothyroidism of the Latin American Thyroid Society (LATS). Clinical practice guidelines for the management of hypothyroidism. Arq Bras Endocrinol Metabol. 2013; 57 (4): 265-91. doi:10.1590/ s0004-27302013000400003

  37. Stagnaro-Green A, et al. American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011; 21 (10): 1081-125. doi: 10.1089/thy.2011.0087

  38. Lazarus J, et al. European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. B. Eur Thyroid J. 2014; 3 (2): 76-94. doi: 10.1159/000362597

  39. Protocols Medicina Materno-fetal Hospital Clínic-Hospital Sant Joan De Déu-Universitat De Barcelona 2017.https://medicinafetalbarcelona.org/protocolos/es/patologiamaterna- obstetrica/tiroides_y_embarazo.pdf




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