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Colegio de Medicina Interna de México.

2020, Number 2

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Med Int Mex 2020; 36 (2)

Angioedema induced by metformin

Rozo-Ortiz EJ, Vargas-Rodríguez LJ, Jiménez-W JP, David-Barinas JS, Tibana-Puentes NL

Language: Spanish
References: 14
Page: 237-241
PDF size: 187.95 Kb.


ABSTRACT

Background: Angioedema is an edema that affects the deep layers of the skin; this disease has prevalence between 20 to 25% of the general population.
Clinical case: A 40-year-old female patient with diabetes mellitus in treatment with biguanides. She presented 10 days after the start of the drug a clinical picture consisting of facial edema associated with pain in the left side of the face, ipsilateral paresthesias, emetic and diarrhea episodes, she was managed with dexamethasone, loratadine and withdrawal of the hypoglycaemic drug. Multiple studies were performed that ruled out diseases, such as temporal artery arteritis, hereditary angioedema and autonomic headache. For what it was considered angioedema secondary to metformin.
Conclusion: The angioedema secondary to metformin has been shown in only one case in the world, in a patient who presented a picture of anaphylaxis, it is a little frequent adverse effect; differential diagnosis was made discarding other possibilities and finally through Naranjo scale it was classified as a definitive adverse reaction.


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