medigraphic.com

2019, Number 4

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2019; 57 (4)

Risk factors associated with lateonset neonatal sepsis

Arias-Arellano S, Cáceres-Aucatoma F, Geyson D, Segarra-Galarza K

Language: Spanish
References: 23
Page: 226-231
PDF size: 125.99 Kb.


ABSTRACT

Background: Sepsis is one of the main causes of morbidity and mortality in neonates.
Objective: To identify the risk factors for neonatal sepsis in a neonatal unit from March to October, 2016.
Methods: Case-control study. The factors analyzed were: a) neonatal factors such as: type of delivery, sex, birth weight, gestational age, criteria for systemic inflammatory response syndrome, type of sepsis (early or late) and blood culture result; B) invasive methods such as: central catheterization, total parenteral nutrition, umbilical catheterization and mechanical ventilation; C) maternal factors such as: number of prenatal controls, infection during pregnancy, premature rupture of membranes, maternal age and maternal fever. Odds Ratio was used to determine association.
Results: For the development of early-onset sepsis, significant risk factors were: thermodynamic imbalance, tachycardia and maternal fever. With regard to lateonset sepsis, significant associations were found for thermodynamic imbalance, umbilical catheterization, mechanical ventilation and insufficient prenatal care.
Conclusions: Thermodynamic imbalance, tachycardia, mechanical ventilation, umbilical catheterization, maternal fever, and insufficient prenatal care were the probable risk factors associated with neonatal sepsis.


REFERENCES

  1. Organzación Mundial de la Salud - UNICEF. Visitas domiciliarias al recién nacido: una estrategia para aumentar la supervivencia. Ginebra, Suiza: OMS; 2012. Disponible en: http://apps.who.int/iris/bitstream/10665/ 70057/1/WHO_FCH_CAH_09.02_spa.pdf

  2. Wheeler DS, Wong HR, Zingarelli B. Pediatric Sepsis - Part I: “Children are not small adults!” Open Inflamm J. 2011;4 (513):4-15. Disponible en: http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=3665507&tool=pmcentrez&rend ertype=abstract

  3. Fernández-Colomer B. Sepsis del recién nacido y del primer semestre de la vida. Rev Chil pediatría. 2008;17 (4):189-206. Disponible en: http://www.aeped.es/sites/ default/files/documentos/21_0.pdf

  4. Lawn JE, Osrin D, Adler A, Cousens S. Four million neonatal deaths: Counting and attribution of cause of death. Paediatr Perinat Epidemiol. 2008;22(5):410-6.

  5. Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, De Bernis L. Evidence-based, cost-effective interventions: How many newborn babies can we save? Lancet. 2005; 365(9463):977-88.

  6. Countdown Coverage Writing Group, Countdown to 2015 Core Group, Bryce J, Daelmans B, Dwivedi A, Fauveau V, et al. Countdown to 2015 for maternal, newborn, and child survival: the 2008 report on tracking coverage of interventions. Lancet. 2008;371(9620): 1247-58.

  7. Shah BA, Padbury JF. Neonatal sepsis: an old problem with new insights. Virulence. 2014;5(1):170-8. Disponible en: http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=3916371&tool=pmcentrez&rendertype=abstract

  8. Melville JM, Moss TJM. The immune consequences of preterm birth. Front Neurosci. 2013;7(7):1-9.

  9. Kung YH, Hsieh YF, Weng YH, Lien RI, Luo J, Wang Y, et al. Risk factors of late-onset neonatal sepsis in Taiwan: A matched case-control study. J Microbiol Immunol Infect. 2013;49(3):430-5. Disponible en: http:// dx.doi.org/10.1016/j.jmii.2013.10.001

  10. Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK Jr, Smith PB, et al. Early and late onset sepsis in very-lowbirth- weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2013;88(Suppl 2): S69-72.

  11. Chiesa C, Panero A, Osborn JF, Simonetti AF, Pacifico L. Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge. Clin Chem. 2004;50(2):279-87.

  12. Wiens MO, Kumbakumba E, Kissoon N, Ansermino JM, Ndamira A, Larson CP. Pediatric sepsis in the developing world: Challenges in defining sepsis and issues in postdischarge mortality. Clin Epidemiol. 2012;4(1):319-25.

  13. Vergnano S. Neonatal sepsis: an international perspective. Arch Dis Child - Fetal Neonatal Ed. 2005;90 (3):F220-f224. Disponible en: http://fn.bmj.com/ cgi/doi/ 10.1136/adc.2002.022863

  14. Ruiz D del RV. Prevalencia de sepsis neonatal y factores asociados en el servicio de neonatología, hospital Vicente Corral Moscoso en Cuenca - Ecuador. El Escorial. 2012;34,56.

  15. Hofer N, Müller W, Resch B. Neonates presenting with temperature symptoms: Role in the diagnosis of early onset sepsis. Pediatr Int. 2012;54(4):486-90.

  16. Ahmad MS, Ali N, Mehboob N, Mehmood R, Ahmad M, Wahid A. Temperature on admission among cases of neonatal sepsis and its association with mortality. J Pak Med Assoc. 2016;66(10):1303-6.

  17. Cohen-Wolkowiez M, Moran C, Benjamin DK, Cotten CM, Clark RH, Smith PB. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009;28(12):1052-6. Disponible en: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 2798577&tool=pmcentrez&rendertype=abstract

  18. Rojas MA, Efird MM, Lozano JM, Bose CL, Rojas MX, Rondón MA, et al. Risk factors for nosocomial infections in selected neonatal intensive care units in Colombia, South America. J Perinatol. 2005;25(8):537-41.

  19. Leal YA, Álvarez-Nemegyei J, Velázquez JR, Rosado- Quiab U, Diego-Rodríguez N, Paz-Baeza E, et al. Risk factors and prognosis for neonatal sepsis in southeastern Mexico: analysis of a four-year historic cohort follow-up. BMC Pregnancy Childbirth. 2012;12(1):48. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/22691696

  20. Yumani DFJ, van den Dungen FA, van Weissenbruch MM. Incidence and risk factors for catheter-associated bloodstream infections in neonatal intensive care. Acta Paediatr. 2013;102(7):e293-8. Disponible en: http://www. ncbi.nlm.nih.gov/pubmed/23627968

  21. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2 Pt 1):285-91.

  22. Partridge S, Balayla J, Holcroft CA, Abenhaim HA. Inadequate Prenatal Care Utilization and Risks of Infant Mortality and Poor Birth Outcome: A Retrospective Analysis of 28, 729, 765 U. S. Deliveries over 8 Years. Am J Perinatol. 2012;29(10):787-794.

  23. Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Risk of Early-Onset Neonatal Infection with Maternal Infection or Colonization: A Global Systematic Review and Meta- Analysis. PLoS Med. 2013;10(8).




2020     |     www.medigraphic.com