2019, Number 2-3
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MEDICC Review 2019; 21 (2-3)
The chronic kidney disease epidemic in El Salvador: A cross-sectional study
Language: English
References: 75
Page: 29-37
PDF size: 365.08 Kb.
ABSTRACT
INTRODUCTION Chronic kidney disease has reached epidemic levels in several Central American countries since the early years of this century. In El Salvador, it is the second cause of death in men, the fifth in persons over 18 years old and the third cause of hospital deaths in the adult population. Its features, especially those of a subtype unassociated with traditional risk factors such as diabetes and high blood pressure, are only partially understood.
OBJECTIVE Estimate the magnitude of chronic kidney disease in the adult population of El Salvador, considering both prevalence of the disease in its diverse forms as well as presence of potential risk factors nationally and in major subpopulations.
METHODS A descriptive, cross-sectional analysis was conducted on data obtained from the Survey of Chronic Non-communicable Diseases in Adults in El Salvador, completed in 2015. The original data (interviews and measurements) were collected between October 2014 and March 2015 from 4817 adults employing a two-stage probabilistic cluster sample, with stratification of primary sampling units. Our analysis, using 20 of the 118 primary variables included in the original survey, focused on point estimation of prevalence rates and means, related to both traditional biological risk factors and nontraditional ones, such as insufficient hydration, strenuous working conditions and exposure to toxic agents. A separate analysis was performed to estimate prevalence of chronic kidney disease from nontraditional causes. Corresponding confidence intervals were calculated with proper weighting.
RESULTS The general prevalence of chronic kidney disease in El Salvador was 12.8% (men 18.0%; women 8.7%). Of the chronically ill kidney patients, 13.1% were between 20 and 40 years of age. Among biological risk factors, the most frequent was high blood pressure (37.0%). Among nontraditional risk factors, high levels of sugary drink consumption (81.0%), insufficient hydration (65.9%) and high levels of exposure to agrochemicals in the work environment (12.6%) were also observed. Prevalence of chronic kidney disease from nontraditional causes was 3.9% (men 6.1%; women 2.2%).
CONCLUSIONS Chronic kidney disease has reached epidemic proportions in El Salvador. The data confirm a health tragedy that, although especially striking older men, also takes a severe toll on young men and women. The results confirm findings of previous research in several Salvadoran agricultural communities. The relatively high level of population exposure to agrochemicals is important and alarming, especially in rural areas, meriting health-impact studies that include and go beyond possible impact on chronic kidney disease.
REFERENCES
Xie Y, Bowe B, Mokdad AH, Xian H, Yan Y, Li T, et al. Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 2018 Sep;94(3):567−81.
Pan American Health Organization. Estrategia Regional y Plan de Acción para Un Enfoque Integrado Sobre la Prevención y el Control de las enfermedades Crónicas. Washington, D.C.: Pan American Health Organization; 2007. 46 p. Spanish.
Salas A, Hinojosa R, Battilana C. Costo de las terapias para tratar la Insufi ciencia Renal Crónica Terminal (IRCT). Diagnóstico [Internet]. 2006 Oct–Dec [cited 2018 Sep 12];45(4). Available from: http://www.fi hu-diagnostico.org.pe/revista/ numeros/2006/oct-dic/182-184.html. Spanish.
Fogarty DG, Taal MW. A stepped care approach to the management of chronic kidney disease. In: Skorecki K, Chertow GM, Marsden PA, Taal MW, Yu ASL, editors. Brenner and Rector’s The Kidney. 10th ed. Philadelphia: Elsevier; 2016. Chapter 62. p. 1987–2026.
Trabanino RG, Aguilar R, Silva CR, Mercado MO, Merino RL. Nefropatía terminal en pacientes de un hospital de referencia en El Salvador. Rev Panam Salud Pública [Internet]. 2002 [cited 2018 Sep12];12(3). Available from: http://www .scielosp.org/pdf/rpsp/v12n3/12875.pdf. Spanish.
Hoy H, Ordúñez P, editors. Epidemic of Chronic Kidney Disease in Agricultural Communities in Central America. Case defi nitions, methodological basis and approaches for public health surveillance. Washington, D.C.: Pan American Health Organization; 2017 Jun.
Wesseling C, Crowe J, Hagstedt C, Jakobsson K, Lucas R, Wegman DH. The epidemic of chronic kidney disease of unknown etiology in Mesoamerica: a call for interdisciplinary research and action. Am J Public Health. 2013 Nov 3;103(11):1927−30.
Herrera Valdés R, Orantes CM, Almaguer López M, López Marín L, Arévalo PA, Smith González MJ, et al. Clinical characteristic of chronic kidney disease of non-traditional causes in women of agricultural communities in El Salvador. Clin Nephrol. 2015;83(7 Suppl1):S56‒63.
Ramírez Rubio O, McClean MD, Amador JJ, Brooks DR. An epidemic of chronic kidney disease in Central America: an overview. J Epidemiol Community Health. 2013 Jan;67(1):1‒3.
World Health Organization. International Statistical Classifi cation of Diseases and Related Health Problems l0th Revision (ICD10) [Internet]. Geneva: World Health Organization; 2010 [cited 2018 Sep 12]. 195 p. Available from: https://www.who.int/cla ssifi cations/icd/ICD10Volume2_en_2010.pdf.
Ordúñez P, Martínez R, Reveiz L, Chapman E, Sáenz C, Soares da Silva A, et al. Chronic kidney disease epidemic in Central América: urgent public health action is needed amid causal uncertainty. PLoS Negl Trop Dis. 2014 Aug 7;8(8):e3019.
Elinder CG, Annika O, Wernerson AO. Mesoamerican nephropathy [Internet]. Massachusetts: UptoDate, Wolters Kluwer Health Division; 2017 Apr 27 [cited 2018 Sep 12]. Available from: https://www.uptodate.com/contents/mesoame rican-nephropathy.
Lozier M, Turcios-Ruiz RM, Noonan G, Ordúñez P. Chronic kidney disease of nontraditional etiology in Central America: a provisional epidemiologic case defi nition for surveillance and epidemiologic studies. Rev Panam Salud Pública. 2016 Nov;40(5):294‒300.
Ministry of Public Health and Social Assistance of El Salvador. Informe de Labores 2012‒2013 [Internet]. San Salvador: Ministry of Public Health and Social Assistance of El Salvador; 2013 [cited 2018 Sep 12]. Available from: https://www .transparencia.gob.sv/institutions/minsal/docu ments/13867/download. Spanish.
Orantes CM, Herrera R, Almaguer M, Brizuela EG, Hernández CE, Bayarre H, et al. Chronic kidney disease and associated risk factors in the Bajo Lempa region of El Salvador: Nefrolempa study, 2009. MEDICC Rev. 2011 Oct;13(4):14–22.
Almaguer M, Herrera R, Orantes CM. Chronic kidney disease of unknown etiology in agricultural communities. MEDICC Rev. 2014 Apr;16(2):9‒15.
Wesseling C, van Wendel B, Crowe J, Rittner R, Sanati NA, Hogstedt C, et al. Mesoamerican nephropathy: geographical distribution and time trends of chronic kidney disease mortality between 1970 and 2012 in Costa Rica. Occup Environ Med. 2015 Oct;72(10):714‒21.
García-Trabanino R, Domínguez J, Jansà JM, Oliver A. [Proteinuria and chronic renal failure in the coast of El Salvador: detection with low cost methods and associated factors]. Nefrologia. 2005;25(1):31‒8. Spanish.
Centers for Disease Control and Prevention (CDC). National Chronic Kidney Disease Fact Sheet, 2017 [Internet]. Atlanta: U.S. Department of Health and Human Resources; Centers for Disease Control and Prevention (CDC); 2017 [cited 2018 Sep 12]. Available from: http://www .cdc.gov/diabetes/pubs/pdf/kidney_factsheet.pdf
Orantes CM, Herrera R, Almaguer M, Brizuela EG, Núñez L, Alvarado NP, et al. Epidemiology of chronic kidney disease in adults of Salvadoran agricultural communities. MEDICC Rev. 2014 Apr;16(2):23‒30.
Herrera R, Orantes CM, Almaguer M, Alfonso P, Bayarre HD, Leiva IM, et al. Clinical characteristics of Chronic Kidney Disease of Nontraditional Causes in Salvadoran Farming Communities. MEDICC Rev. 2014 Apr;16(2):39‒48.
López-Marín L, Chávez Y, García XA, Flores WM, García YM, Herrera R, et al. Histopathology of chronic kidney disease of unknown etiology in Salvadoran agricultural communities. MEDICC Rev. 2014 Apr;16(2):49‒54.
Orantes CM, Herrera R, Almaguer M, Brizuela EG, Alvarado NP, Fuentes JE, et al. Chronic kidney disease in children and adolescents in Salvadoran farming communities: Nefrosalva Pediatric Study (2009‒2011). MEDICC Rev. 2016 Jan- Apr;18(1–2):23‒30.
CHMCA. San Salvador Declaration: comprehensive management of chronic tubulinterstitial kidney disease of Central America (CTKDC) predominantly affecting agricultural communities. Council of Health Ministers of Central America. MEDICC Rev [Internet]. 2014 Apr [cited 2018 Sep 12];16(2). Available from: http://www.me dicc.org/medic-creview/documents/San_Sal vador_English_online.pdf
COMISCA. Resolución de la XXXV Reunión del Consejo de Ministros de Salud de Centro América y República Dominicana [Internet]. San Salvador: COMISCA; 2011 [cited 2018 Sep 12]. Available from: http://www.sica.int/busqueda/ busqueda_basica.aspx?ldMod=3. Spanish.
Pan American Health Organization. 52nd Directing Council. Resolution CD52.R10. Chronic kidney disease in agricultural communities in Central America [Internet]. Washington, D.C.: Pan American Health Organization; 2013 Oct [cited 2018 Sep 12]. Available from: http://www .paho.org/hq/index.php?option=com_content& view=article&id=8833
Orduñez P, Sáenz C, Martínez R, Chapman E, Reveiz L, Becerra F. The Epidemic of Chronic Kidney Disease in Central America. Lancet Glob Health. 2014 Aug;2(8):e440‒1.
Ministry of Health of El Salvador; National Institute of Health of El Salvador. Encuesta nacional de enfermedades crónicas no transmisibles en población adulta de El Salvador ENECAELS. Resultados relevantes [Internet]. San Salvador, El Salvador: Ministry of Health of El Salvador; National Institute of Health of El Salvador; 2015 [cited 2018 Sep 12]. 36 p. Available from: http://www.salud.gob.sv/archi vos/comunicaciones/archivos_comunicados2017/ pdf/presentaciones_evento20032017/01-ENECA -ELS-2015.pdf. Spanish.
World Health Organization. El Manual de vigilancia STEPS de la OMS: el método STEPwise de la OMS para la vigilancia de los factores de riesgo de las enfermedades crónicas. Geneva: World Health Organization; 2006. Spanish.
Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003 Jan;41(1):1–12.
Django Software Foundation [Internet]. [place unknown]: Django Software Foundation; c2005– 2019. Django Documentation Release 1.5.3; 2013 Sep 10 [cited 2018 Sep 12]. Available from: https://docs.djangoproject.com/en/1.5/
World Health Organization. Operational Guidelines for Ethics Committees that review Biomedical Research. Geneva: World Health Organization; 2000. 32 p.
Stevens LA, Claybon MA, Schmid CH, Chen J, Horio M, Imai E, et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular fi ltration rate in multiple ethnicities. Kidney Int. 2011 Mar;79(5):555‒62.
Kidney Disease Improving Global Outcomes (KDIGO). 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. International Society of Nephrology. Kidney Int Suppl [Internet]. 2013 [cited 2018 Sep 12];3(1):1–150. Available from: https://www .sciencedirect.com/journal/kidney-international -supplements/vol/3/issue/1
Epidat: programa para análisis epidemiolóxico de datos. Versión 4.2, xullo 2016. Galicia: Consellería de Sanidade, Xunta de Galicia; Pan American Health Organization; World Health Organization; Universidade CES, Colombia; 2016 Jul. Spanish.
Kalton G, Flores I. Weighting methods. J Off Statistics. 2003;19(2):81‒97.
Lundström S, Särndal CE. Calibration as a standard method for the treatment of nonresponse. J Off Statistics. 1999;15(2):305‒27.
Brück K, Jager KJ, Dounousi E, Kainz A, Nitsch D, Ärnlöv J, et al. Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review. Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv6−iv16.
National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classifi cation, and Stratifi cation. Am J Kidney Dis. 2002 Feb;39 (2 Suppl 1):S1–266.
Orantes Navarro CM, Herrera Valdés R, Almaguer López M, Calero DJ, Fuentes de Morales J, Alvarado Ascencio NP, et al. Epidemiological characteristic of chronic kidney disease of nontraditional causes in women of agricultural communities of El Salvador. Clin Nephrol. 2015;83(7 Suppl 1):S24−31.
Raines N, González M, Wyatt C, Kurzrok M, Pool C, Lemma T, et al. Risk factors for reduced glomerular fi ltration rate in a Nicaraguan community affected by Mesoamerican nephropathy. MEDICC Rev. 2014 Apr;16(2):16‒22.
Gifford FJ, Gifford RM, Eddleston M , Dhaun N. Endemic nephropathy around the world. Kidney Int Rep. 2017 Mar;2(2):282–92.
Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors-United States, 1999- 2004. Morb Mortal Wkly Rep [Internet]. 2007 Mar 2 [cited 2018 Sep 12];56(8):161–5. Available from: https://www.cdc.gov/mmwr/preview/ mmwrhtml/mm5608a2.htm
Centers for Disease Control and Prevention (CDC). Age-adjusted prevalence of CKD Stages 1-4 by Gender 1999-2012. Chronic Kidney Disease (CKD) Surveillance Project [Internet]. Atlanta: Centers for Disease Control and Prevention (CDC); 2016 [cited 2019 Feb 12] Available from: https://nccd.cdc.gov
Takahashi S, Okada K, Yanai M. The Kidney Early Evaluation Program (KEEP) of Japan: results from the initial screening period. Kidney Int Suppl [Internet]. 2010 Mar [cited 2018 Sep12];77(116 Suppl):S17–23. Available from: https://www.kidney-international.org/article/ S0085-2538(15)54182-3/fulltext
Mathew TH, Corso O, Ludlow M, Boyle A, Cass A, Chadban SJ, et al. Screening for chronic kidney disease in Australia: a pilot study in the community and workplace. Kidney Int Suppl. 2010 Mar;77(116 Suppl):S9–16.
Otero A, de Francisco AL, Gayoso P, García F; EPIRCE Study Group. Prevalence of chronic renal disease in Spain: Results of the EPIRCE study. Nefrologia [Internet]. 2010 [cited 2018 Sep 12];30(1):78–86. Spanish, English. Available from: http://dialnet.unirioja.es/servlet/ articulo?codigo=3361355
Hallan SI, Coresh J, Astor BC, Äsberg A, Powe NR, Romundstad S, et al. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol [Internet]. 2006 Aug [cited 2018 Sep 12];17(8):2275–84. Available from: http://jasn .asnjournals.org/content/17/8/2275.long
Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Pub Health. 2008 Apr 11;8:117.
Cerón A, Fort MP, Morine CM, Lou-Meda R. Chronic kidney disease among children in Guatemala. Rev Panam Salud Pública. 2014;36(6):376‒82.
Valcke M, Orantes CM, Lavasseur ME. Chronic disease of undetermined etiology and pesticide exposure: an update on recent data. Presentation at the Second International Research Workshop on Mesoamerican Nephropathy, Consortium on the Epidemic of Nephropathy in Central America and México (CENCAM) and Central American Program on Work, Environment and Health (SALTRA); 2015 Nov 18–20; San José, Costa Rica. San Juan de Costa Rica: SALTRA; 2015.
Sanoff SL, Callejas L, Alonso CD, Hu Y, Colindres RE, Chin H, et al. Positive association of renal insuffi ciency with agriculture employment and unregulated alcohol consumption in Nicaragua. Ren Fail. 2010;32(7):766‒77.
O’Donnell JK, Tobey M, Weiner DE, Stevens LA, Johnson S, Stringham P, et al. Prevalence of and risk factors for chronic kidney disease in rural Nicaragua. Nephrol Dial Transplant. 2011 Sep;26(9):2798‒805.
Torres C, Aragón A, González M, López I, Jakobsson K, Elinder CG, et al. Decreased kidney function of unknown cause in Nicaragua: a community-based survey. Am J Kidney Dis. 2010 Mar;55(3):485−96.
Payán-Rentería R, Garibay-Chávez G, Rangel- Ascencio R, Preciado-Martínez V, Muñoz-Islas L, Beltrán-Miranda C, et al. Effect of chronic pesticide exposure in farm workers of a Mexico community. Arch Environ Occup Health. 2012;67(1):22‒30.
Ruiz-Suárez LE, Castro-Chan RA, Rivero-Pérez NE. Levels of organochlorine pesticides in blood plasma from residents of malaria-endemic communities in Chiapas, Mexico. Int J Environ Res Public Health. 2014 Oct;11(10):44‒60.
Lebov JF, Engel S, Richardson D, Hogan SL, Hoppin JA, Sandler DP. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study. Occup & Environm Med. 2016 Jan;73(1):3‒12.
Hsu CY, Iribarren C, McCulloch CE, Darbinian J, Go AS. Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med. 2009 Feb 23;169(4):342‒50.
Jayasumana C, Gunatilake S, Senanayake P. Glyphosate, hard water and nephrotoxic Metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka? Int J Environ Res Public Health. 2014 Feb 20;11(2):2125‒47.
Jayasumana C, Paranagama P, Agampodi S, Wijewardane C, Gunatilake S, Siribaddana S. Drinking well water and occupational exposure to herbicides is associated with chronic kidney disease, in Padavi Sripura, Sri Lanka. Environ Health. 2015 Jan 18;14:6.
Bravo V, Rodríguez T, Van Wendel de Joode B, Canto N, Calderón GR, Turcios M, et al. Monitoring pesticide use and associated health hazards in Central America. Int J Occup Environ Health. 2011Jul–Sep;17(3):258−69.
Weaver VM, Fadrowski JJ, Jaar BG. Global dimensions of chronic kidney disease of unknown etiology (CKDu): a modern era environmental and/or occupational nephropathy? BMC Nephrol. 2015 Aug 19;16:145.
Chandrajith R, Nanayakkara S, Itai K, Aturaliya TN, Dissanayake CB, Abeysekera T, et al. Chronic kidney diseases of uncertain etiology (CKDue) in Sri Lanka: geographical distribution and environmental implications. Environ Geochem Health. 2011 Jun;33(3):267–78.
Elledge MF, Redmon JH, Levine KE, Levine KE, Wickremasinghe RJ, Wanigasariya KP, et al. Chronic kidney disease of unknown etiology in Sri Lanka: quest for understanding and global implications. Research Brief North Carolina: RTI Press [Internet]. 2014 May [cited 2018 Sep 12]; [about 4 pages]. Available from: https://www.rti .org/sites/default/files/resources/rti-publication -fi le-fb1d2db7-bd51-4f85-a8d1-3e38ba9c4da7.pdf
Inter Press Service [Internet]. Rome: Inter Press Service; c2019. Health. Study links kidney disease in Sri Lanka’s farm belt to agrochemicals; 2012 [cited 2018 Sep 12]; [about 3 screens]. Available from: http://www.ipsnews.net/2012/08/ study-links-kidney-disease-in-sri-lankas-farm -belt-to-agrochemicals/
Jayatilake N, Mendis S, Maheepala P, Mehta FR; CKDu National Research Project Team. Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country. BMC Nephrol. 2013 Aug 27;14:180.
Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF, et al. What do we know about chronic kidney disease in India: fi rst report of the Indian CKD registry. BMC Nephrol. 2012 Mar 6;13:10.
Singh AK, Farag YM, Mittal BV, Subramanian KK, Reddy SR, Acharya VN, et al. Epidemiology and risk factors of chronic kidney disease in India – results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC Nephrol. 2013 May 28;14:114.
El Minshawy O, Ghabrah T, El Bassuoni E. Endstage renal disease in Tabuk Area, Saudi Arabia: an epidemiological study. Saudi J Kidney Dis Transpl. 2014 Jan;25(1):192‒5.
Barsoum RS. Burden of chronic kidney disease: North Africa. Kidney Int Suppl (2011). 2013 May;3(2):164‒6.
Seck SM, Doupa D, Gueye L, Dia CA. Prevalence of chronic kidney disease and associated factors in Senegalese populations: a communitybased study in Saint-Louis. Nephrourol Mon. 2014 Sep 5;6(5):e19085.
Jayasumana C, Orantes C, Herrera R, Almaguer M, López L, Silva LC, et al. Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants. Nephrol Dial Transplant. 2017 Feb 1;32(2):234‒41.
Wijkström J. Chronic kidney disease of unknown etiology in Central America and Sri Lanka: renal morphology and clinical characteristics [dissertation]. [Stockholm]: Karolinska University Department of Clinical Science, Intervention and Technology; 2017 [cited 2018 Sep 12]. 63 p. Available from: https://openarchive.ki.se/xmlui/ bitstream/handle/10616/46000/Thesis_Julia_Wi jkstrom.pdf?sequence=1
Bandarage A. Political economy of epidemic kidney disease in Sri Lanka. SAGE Open. 2013 Oct–Dec;3(4):1–13.
Reveiz L, Pinzón-Flórez C, Glujovsky D, Elias V, Orduñez P. Establecimiento de prioridades de investigación en la enfermedad renal crónica de causas no tradicionales en Centroamérica. Rev Panam Salud Pública. 2018 Mar;42:13. Spanish.