2019, Number 2
Inulin-type fructans: effect on gut microbiota, obesity and satiety
Language: Spanish
References: 49
Page: 134-145
PDF size: 359.61 Kb.
ABSTRACT
Background: Short-chain inulin-type fructans (ITF) are named fructooligosaccharides (FOS) and considered prebiotics to benefit the health of the host.Objective: To analyze three of the most important health benefits of inulin-type fructans as prebiotics.
Methodology: Documents published in different databases (PubMed, Medline, NCBI) in English were reviewed. Those which provided data on the influence of prebiotics on the gut microbiota, obesity and satiety were chosen. The documentary analysis method was used to evaluate the results of different clinical trials.
Results: A total of 70 articles were reviewed, of which 49 were selected and contained controlled clinical trials and evidence of the beneficial health effects of inulin-type fructans.
Conclusions: Inulin-type fructans in general, and fructooligosaccharides (FOS) in particular, when fermented in the gastrointestinal tract produce short-chain fatty acids (SCFA); these fermentation products favor the development of beneficial microorganisms to the detriment of other harmful ones. Similarly, short chain fatty acids can regulate lipid metabolism and satiety.
REFERENCES
Sudhir PS, Jadaun JS, Narnoliya LK, Pandeyl A. Prebiotic oligosaccharides: special focus on fructooligosaccharides, its biosynthesis and bioactivity. Appl Biochem Biotechnol [Internet]. 2017 [cited 2018 Jan 03];183(2):613-35. Available from: https://link.springer.com/article/10.1007%2Fs12010-017-2605-2
Han YZ, Zhou CC, Xu YY, Yao JX, Chi Z, Chi ZM, et al. High-efficient production of fructo-oligosaccharides from inulin by a two-stage bioprocess using an engineered Yarrowia lipolytica strain. Carbohydr Polym [Internet]. 2017 [cited 2018 Oct 1];173:592-9. Available from: https://www.sciencedirect.com/science/article/pii/S014486171730680X?via%3Dihub
Flores-Maltos DA, Mussatto SI, Contreras-Esquivel JC, Rodriguez-Herrera R, Teixeira JA, Aguilar CN. Biotechnological production andapplication of fructooligosaccharides. Crit Rev Biotechnol [Internet]. 2016 [cited 2016 Dec 20];36(2):259-67. Available from: https://www.tandfonline.com/doi/abs/10.3109/07388551.2014.953443?journalCode=ibty20
Hernández L, Menéndez C, Pérez ER, Martínez D, Alfonso D, Trujillo LE, et al. Fructooligosaccharides production by Chedonorus arundinaceus sucrose:sucrose 1-fructosyltransferase constitutively expressed to high levels in Pichia pastoris. J Biotechno [Internet]. 2018 [cited 2019 Dec 20];266:59-71. Available from: https://www.sciencedirect.com/science/article/pii/S0168165617317650?via%3Dihub
Ose R, Hirano K, Maeno S, Nakagawa J, Salminen S, Tochio T, et al. The ability of human intestinal anaerobes to metabolize different oligosaccharides: Novel means for microbiota modulation? Anaerobe [Internet]. 2018 [cited 2018 Dec 26];51:110-9. Available from: https://www.sciencedirect.com/science/article/pii/S1075996418300751?via%3Dihu
Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, Emanuele E. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes [Internet]. 2016 [cited 2018 Nov 30];7(5):625-30. Available from: https://www.wageningenacademic.com/doi/pdf/10.3920/BM2016.0089
Boonma P, Spinler JK, Venable SF, Versalovic J, Tumwasorn S. Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells. BMC Microbiol [Internet]. 2014 [cited 2016 Jul 8];14:177. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094603/
den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res [Internet]. 2013 [cited 2016 Dec 20];54(9):2325-40. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735932/
Tochio T, Kadotam Y, Tanaka T, Koga Y. 1-Kestose, the Smallest Fructooligosaccharide Component, Which Efficiently Stimulates Faecalibacterium prausnitzii as Well as Bifidobacteria in Humans. Foods [Internet]. 2018 [cited 2018 Dec 26];7(9):140. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164784/
Liu F, Li P, Chen M, Luo Y, Prabhakar M, Zheng H, et al. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population. Sci Rep [Internet]. 2017 [cited 2018 Sep 18];7(1):11789. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603605/
Closa-Monasterolo R, Gispert-Llaurado M, Luque V, Ferre N, Rubio-Torrents C, Zaragoza-Jordana M, et al. Safety and efficacy of inulin and oligofructose supple mentation in infant formula: Results from a randomized clinical trial. Clin Nutr [Internet]. 2013 [cited 2016 Dec 20];32(6):918-27. Available from: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0 S0261561413000551.pdf?locale=es_ES&searchIndex
Lakshminarayanan B, Guinane CM, O'Connor PM, Coakley M, Hill C, Stanton C. Isolation and characterization of bacteriocin‐producing bacteria from the intestinal microbiota of elderly Irish subjects. J Appl Microbiol [Internet]. 2013 [cited 2016 Dec 22];114(3):886-98. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/jam.12085
Ortega-González M, Sánchez de Medina F, Molina-Santiago C, López-Posadas R, Pacheco D, Krell T, et al. Fructooligosacharides reduce Pseudomonas aeruginosa PAO1 pathogenicity through distinct mechanisms. PLoS One [Internet]. 2014 [cited 2018 Jan 26];9(1):1-12. Available from: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085772&type=printable
Ambalam P, Raman M, Purama RK, Doble M. Probiotics, Prebiotics and Colorectal Cancer Prevention, Best Pract Res Clin Gastroenterol [Internet]. 2016 [cited 2016 Dec 20];30(1):119-31. Available from: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0-S1521691816000135.pdf?locale=es_ES&searchIndex
Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology [Internet]. 2017[cited 2018 Jan 26];153(3):711-22. Available from: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0-S0016508517356986.pdf?locale=es_ES&searchIndex=
Dewulf EM, Cani PD, Claus SP, Fuentes S, Puylaert PG, Neyrinck AM, et al. Insight into the prebiotic concept: Lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut [Internet]. 2013 [cited 2016 Dec 20];62(8):1112-21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711491/
Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol [Internet]. 2013 [cited 2016 Feb 18];27(1):73-83. Available from: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S1521691813000619?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1521691813000619%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.ncbi.nlm.nih.gov%2F
Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr [Internet]. 2009 [cited 2016 Jun 03];89(6):1751-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827013/
Genta S, Cabrera W, Habib N, Pons J, Carillo IM, Grau A, et al. Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clin Nutr [Internet]. 2009 [2016 Dec];28(2):182-7. Available from: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S0261561409000302?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0261561409000302%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.ncbi.nlm.nih.gov%2F
Kumar Bharti S, Krishnan S, Kumar A, Kishore Rajak K, Murari K, Kumar Bharti B, et al. Antidiabetic activity and molecular docking of fructooligosaccharides produced by Aureobasidium pullulans in poloxamer-407-induced T2DM rats. Food Chem [Internet]. 2013 [cited 2015 Jan 15];136(2):813-21. Available from: https://www.sciencedirect.com/science/article/pii/S0308814612013799?via%3Dihub
Teixeira G, Castro G, Bastos AB, Leităo PR, Botelho S. Fructo-oligosaccharide effects on serum cholesterol levels. An overview. Acta Cir Bras [Internet]. 2015 [cited 2016 Dec 22];30(5):366-70. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000500366&lng=en&nrm=iso&tlng=en
Gomes da Silva MF, Dionísio AP, Ferreira Carioca AA, Silveira Adriano L, Pinto CO, Pinto de Abreu, et al. Yacon syrup: Food applications and impact on satiety in healthy volunteers. Food Res Int [Internet]. 2017 [cited 2018 Oct 22];100(Pt 1):460-467. Available from: https://www.sciencedirect.com/science/article/pii/S0963996917303587?via%3Dihub
Reimer RA, Willis HJ, Tunnicliffe JM, Park H, Madsen KL, Soto-Vaca A. Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial. Mol Nutr Food Res [Internet]. 2017 [cited 2018 Jan 03];61(11). Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201700484
Daud NM, Ismail NA, Thomas EL, Fitzpatrick JA, Bell JD, Swann JR, et al. The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity [Internet]. 2014 [cited 2016 Dec 20];22(6):1430-8. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/oby.20754.
Verhoef SPM, Meyer D, Westerterp KR. Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake. Br J Nutr [Internet] 2011 [cited 2016 Dec 22];106(11):1757-62. Available from: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-oligofructose-on-appetite-profile-glucagonlike-peptide-1-and-peptide-yy336-concentrations-and-energy-intake/404F50E31E45AC2E85CA7291B0641180
Pedersen C, Lefevre S, Peters V, Patterson M, Ghatei MA, Morgan LM, et al. Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study. Appetite [Internet] 2013 [cited 2016 Dec 22];66:44-53. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23474087
Chambers ES, Morrison DJ, Frost G. Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Proc Nutr Soc [Internet] 2015 [cited 2016 Jul 8];74(3):328-36. Available from: https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A1EFBE12AD6F9838EBE3D7314D1EE1B4/S0029665114001657a.pdf/control_of_appetite_and_energy_intake_by_scfa_what_are_the_potential_underlying_mechanisms.pdf
Isken F, Klaus S, Osterhoff M, Pfeiffer AF Weickert MO. Effects of long-term soluble vs. Insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice. J Nutr Biochem [Internet]. 2010 [cited 2016 Apr 16];21(4):278-84. Available from: https://www.sciencedirect.com/science/article/pii/S0955286309000059?via%3Dihub
Poeker SA, Geirnaert A, Berchtold L, Greppi A, Krych L, Steinert RE, et al. Understanding the prebiotic potential of different dietary fibers using an in vitro continuous adult fermentation model (PolyFermS). Sci Rep [Internet]. 2018 [2019 Jan 12];8(1):4318. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847601/