2019, Number 2
Basal cell carcinoma of the face treated with HeberFERON
Language: Spanish
References: 15
Page: 87-98
PDF size: 192.68 Kb.
ABSTRACT
Background: Basal cell carcinoma is the most frequent non-melanoma skin cancer, it is a tumor of local invasion and slow growth; it has its origin from the epidermal cells of the hair follicles or the basal cells of the epidermis; sometimes it can suffer uncontrolled growth, not respond to treatments and cause deformity; ultraviolet radiation is the main factor in the genesis of this disease.Objective: To describe the results of the application of HeberFERON in a series of cases with basal cell carcinoma of the face.
Methodology: An observational, longitudinal descriptive study was carried out in a series of 32 clinical cases of basal cell carcinoma of the face that attended the dermatology office of the Polyclinic Center. Those with clinical, dermatoscopic and histopathological diagnosis were included. An initial evaluation was carried out, during the treatment and 16 weeks after it, 10.5 IU of HeberFERON was administered 3 times per week until 9 doses were completed. The variables were the response to treatment and the presence or absence of adverse events.
Results: Male sex, white skin and the location of the neoplasm in the nose predominated; a complete response was achieved in most patients. Adverse events presented pain at the injection site, fever and malaise.
Conclusions: The objective response to treatment was favorable in the majority of patients treated with HeberFERON.
REFERENCES
Ricci Volpato LE, Palma Faria Volpato MC, De Carvalho e Silva LA, De Souza Castro PH, Henrique Borges A. Prótesis nasal sostenida por armaduras de gafas. Rev Cubana Estomatol [Internet]. 2016 [citado 2019 ene 15];53(3):146-52. Disponible en: http://www.revestomatologia.sld.cu/index.php/est/article/view/1074
Alcalá Pérez D, Medina Bojórquez A, Torres González S, Navarrete Franco G, Ramos Garibay A, Peralta Pedrero ML, et al. Correlación clínica, histológica y dermatoscópica del carcinoma basocelular. Rev Cent Dermatol Pascua [Internet] 2013 [citado 2019 ene 15];22(1):6-14. Disponible en: https://www.medigraphic.com/pdfs/derma/cd-2013/cd131a.pdf
Mejía AM, Velásquez MM. Biología e inmunopatogénesis del carcinoma espinocelular y el basocelular. Rev Asoc Colomb Dermatol [Internet]. 2013 [citado 2019 ene 15];21(2):159-68. Disponible en: https://revistasocolderma.org/sites/default/files/biologia_e_inmunopatogenesis_del_carcinoma_espinocelular_y_el_basocelular.pdf
Hernández-Zárate SI, Medina-Bojórquez A, López-Tello Santillán Al, Alcalá-Pérez D. Epidemiología del cáncer de piel en pacientes de la Clínica de Dermato-oncología del Centro Dermatológico Dr. Ladislao de la Pascua. Estudio retrospectivo de los últimos ocho años. Dermatol Rev Mex [Internet]. 2012 [citado 2018 dic 25];56(1):30-37. Disponible en: https://www.medigraphic.com/pdfs/derrevmex/rmd-2012/rmd121e.pdf
Anasagasti-Angulo L, García-Vega Y, Barcelona-Pérez S, López-Saura P, Bello-Rivero I. Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study. BMC Cancer [Internet]. 2009 [cited 2019 Jan 15];9:262. Available from: http://www.biomedcentral.com/1471-2407/9/262
Negrín Cáceres Y, Cabrera Romero AC, Cárdenas Monzón L, Ferrer Pérez A, Batista-Hernández NE. Tratamiento del carcinoma basocelular periocular con una combinación sinérgica de interferones alpha-2b y gamma. Rev Mex Oftalmol [Internet]. 2018 [citado 2019 ene 15];92(3):136-43. Disponible en: https://pdfs.semanticscholar.org/ec92/47dc68263e7dd07bce68b887b87022448f1e.pdf
Anasagasti-Angulo L, Garcia-Vega Y, Collazo Caballero S, Jimenez-Barban Y, Tijerino-Arrieta E, Ballester-Caballero Y, et al. HeberFERON, formulation based on IFNs alpha 2b and gamma for the treatment of non-melanoma skin cancer. AMJ [Internet]. 2017 [citado 2019 ene 15];10(6):509-15. Available from: https://www.researchgate.net/publication/318191920_HeberFERON_formulation_based_on_IFNs_alpha2b_and_gamma_for_the_treatment_of_non-melanoma_skin_cancer
Drake-Sosa DV, Rojas-Barlys L. HeberFERON en pacientes con carcinoma basocelular tratados en el municipio Puerto Padre, Las Tunas. Rev Electr Dr. Zoilo E. Marinello Vidaurreta [Internet]. 2018 [citado 2019 ene 15];43(6). Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/1573/pdf_531
Viñas García M, Algozaín Acosta Y, Álvarez Campos L, Quintana Díaz JC. Comportamiento del carcinoma basocelular facial en Artemisa durante la última década. Rev Cubana Estomatol [Internet]. 2011 Jun [citado 2019 Jun 23];48(2):121-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072011000200004