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Organo Oficial de la Sociedad Mexicana de Urología

2019, Number 6

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Rev Mex Urol 2019; 79 (6)

Hyperglycemia: the metabolic syndrome component that aggravates erectile dysfunction in Mexican patients

Espinosa-Marrón A, Quiñones-Capistrán CA, Rubio-Blancas A, Milke-García MP, Castillejos-Molina RA

Language: English
References: 31
Page: 1-12
PDF size: 246.10 Kb.


ABSTRACT

Objectives: To analyze the relationship between erectile dysfunction and metabolic syndrome in a group of Mexican patients, study the influence of other morbidity factors on erectile dysfunction, and define the specific metabolic syndrome components most associated with erectile dysfunction severity.
Materials and methods: A descriptive, cross-sectional study was conducted on a group of 86 adult Mexican patients previously diagnosed with erectile dysfunction. Participants were classified as presenting with or not presenting with metabolic syndrome. Anthropometric, biochemical, and clinical parameters were determined and erectile dysfunction severity, alcohol or tobacco consumption, and depressive behavior were identified through validated questionnaires. The results were compared between the two groups.
Results: The anthropometric measures, laboratory values, and clinical characteristics were significantly different between the two groups. More patients with severe and moderate erectile dysfunction were identified in the group with metabolic syndrome. Of the metabolic syndrome components, glycated hemoglobin ›5.7% and fasting glucose ›110 mg/dl were significantly associated with the development of erectile dysfunction.
Limitations: The size of our study sample was a limitation, as was the observational and cross-sectional study design.
Originality: Our study results suggest that metabolic syndrome contributed to the progression of erectile dysfunction in the Mexican sample analyzed, with hyperglycemia being the most strongly associated factor.
Conclusions: Metabolic syndrome components were shown to aggravate erectile dysfunction, particularly the lack of glycemic control. The inclusion of fasting glucose and glycated hemoglobin as complementary biochemical screening in patients with erectile dysfunction should be assessed.


REFERENCES

  1. Grundy SM. Metabolic syndrome update. Trends Cardiovasc Med. 2016;26(4):364–73. doi: 10.1016/j.tcm.2015.10.004

  2. National Cholesterol Education Program. Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction: executive summary. National Heart, Lung and Blood Institute, National Institutes of Health. Arch Intern Med. 1991;151(6):1071–84. doi: 10.1001/archinte.151.6.1071

  3. Gorgel SN, Gorgel A, Sefik E. Sexual Function in Male Patients with Metabolic Syndrome and Effective Parameters on Erectile Dysfunction. Int Braz J Urol. 2014;40(1):56–61. doi: 10.1590/ S1677-5538.IBJU.2014.01.08

  4. Rojas R, Aguilar-Salinas CA, Jiménez-Corona A, Shamah-Levy T, Rauda J, Avila-Burgos L, et al. Metabolic syndrome in Mexican adults: results from the National Health and Nutrition Survey 2006. Salud Publica Mex. 2010;52 Suppl 1: S11- 18. doi: 10.1590/s0036-36342010000700004

  5. Salas R, Bibiloni M del M, Ramos E, Villarreal JZ, Pons A, Tur JA, et al. Metabolic syndrome prevalence among Northern Mexican adult population. PLoS ONE. 2014;9(8): e105581. doi: 10.1371/journal.pone.0105581

  6. Wentzell E, Salmeron J. Prevalence of Erectile Dysfunction and Its Treatment in a Mexican Population: Distinguishing between Erectile Function Change and Dysfunction. Journal of Men s Health. 2009; 6:56–62. doi: 10.1016/j. jomh.2008.09.009

  7. Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016; 2:16003. doi: 10.1038/nrdp.2016.3

  8. Borges R, Temido P, Sousa L, Azinhais P, Conceição P, Pereira B, et al. Metabolic Syndrome and Sexual (Dys)function. The Journal of Sexual Medicine. 2009;6(11):2958– 75. doi: 10.1111/j.1743-6109.2009.01412.x

  9. Bal K, Öder M, Şahin AS, Karataş CT, Demir Ö, Can E, et al. Prevalence of Metabolic Syndrome and Its Association with Erectile Dysfunction Among Urologic Patients: Metabolic Backgrounds of Erectile Dysfunction. Urology. 2007;69(2):356–60. doi: 10.1016/j. urology.2006.09.057

  10. Ning L, Yang L. Hypertension might be a risk factor for erectile dysfunction: a metaanalysis. Andrologia. 2017;49(4). doi: 10.1111/ and.12644

  11. Kouidrat Y, Pizzol D, Cosco T, Thompson T, Carnaghi M, Bertoldo A, et al. High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies. Diabet Med. 2017;34(9):1185–92. doi: 10.1111/ dme.13403

  12. Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, Montorsi P, et al. A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease. European Urology. 2014;65(5):968–78. doi: 10.1016/j.eururo.2013.08.023

  13. Traish AM, Feeley RJ, Guay A. Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. FEBS J. 2009;276(20):5755–67. doi: 10.1111/j.1742-4658.2009.07305.x

  14. Figueroa-García J, Pérez-Patraca A de J. Association of glycemic control and erectile dysfunction in diabetic patients. Rev Mex Urol. 2017;77(1):5–11.

  15. Chen K, Mi H, Gao Y, Tan A, Lu Z, Wu C, et al. Metabolic Syndrome: A Potential and Independent Risk Factor for Erectile Dysfunction in the Chinese Male Population. Urology. 2012;80(6):1287–92. doi: 10.1016/j. urology.2012.08.028

  16. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11(6):319–26. doi: 10.1038/ sj.ijir.3900472

  17. Gutiérrez JP, Rivera-Dommarco J, Shamah- Levy T, Villalpando-Hernández S, Franco A, Cuevas-Nasu L, et al. Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales. Cuernavaca: Instituto Nacional de Salud Pública; 2012. 196 p. Available from: https://ensanut.insp. mx/encuestas/ensanut2012/doctos/informes/ ENSANUT2012ResultadosNacionales.pdf

  18. Hajer GR, van Haeften TW, Visseren FLJ. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008;29(24):2959–71. doi: 10.1093/eurheartj/ ehn387

  19. Méndez-Hernández P, Dosamantes-Carrasco LD, Siani C, Pierlot R, Martínez-Gómez M, Rivera-Paredez B, et al. Mealtime habits and risk of developing the metabolic syndrome or insulin resistance among Mexican adults. Br J Nutr. 2016;116(10):1824–33. doi: 10.1017/ S0007114516003329

  20. Chao J-K, Kuo W-H, Chiang H-S, Hwang TI-S, Chao I-C, Chiang S-K. Association of metabolic syndrome, atherosclerosis risk factors, sex hormones in ED in aboriginal Taiwanese. Int J Impot Res. 2012;24(4):141–6. doi: 10.1038/ ijir.2012.5

  21. Besiroglu H, Otunctemur A, Ozbek E. The Relationship Between Metabolic Syndrome, Its Components, and Erectile Dysfunction: A Systematic Review and a Meta-Analysis of Observational Studies. J Sex Med. 2015 Jun 1;12(6):1309–18. doi: 10.1111/jsm.12885

  22. Cuéllar de León AJ, Ruiz García V, Campos González JC, Pérez Hoyos S, Brotons Multóe F. Prevalencia de disfunción eréctil en pacientes con hipertensión arterial. Med Clin (Barc). 2002;119(14):521–6.

  23. Akbaraly TN, Kivimäki M, Brunner EJ, Chandola T, Marmot MG, Singh-Manoux A, et al. Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults: Results from the Whitehall II study. Diabetes Care. 2009 Mar 1;32(3):499–504. doi: 10.2337/dc08-1358

  24. Barrett-Connor E. Heart Disease Risk Factors Predict Erectile Dysfunction 25 Years Later (The Rancho Bernardo Study). American Journal of Cardiology. 2005;96(12):3–7. doi: 10.1016/j.amjcard.2005.07.012

  25. Kim Jay H., Klyachkin Michael L., Svendsen Einar, Davies Mark G., Hagen Per-Otto, Carson Culley C. Experimental Hypercholesterolemia in Rabbits Induces Cavernosal Atherosclerosis with Endothelial and Smooth Muscle Cell Dysfunction. J Urol. 1994;151(1):198–205. doi: 10.1016/S0022-5347(17)34916-9

  26. Maseroli E, Corona G, Rastrelli G, Lotti F, Cipriani S, Forti G, et al. Prevalence of Endocrine and Metabolic Disorders in Subjects with Erectile Dysfunction: A Comparative Study. The Journal of Sexual Medicine. 2015;12(4):956–65. doi: 10.1111/jsm.12832

  27. Pohjantähti-Maaroos H, Palomäki A, Hartikainen J. Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis. BMC Cardiovascular Disorders. 2011;11(1):36. doi: 10.1186/1471- 2261-11-36

  28. Xu Y, Zhang Y, Yang Y, Liu L, Chen Y, Liu X. Prevalence and correlates of erectile dysfunction in type 2 diabetic men: a population-based crosssectional study in Chinese men. International Journal of Impotence Research. 2019;31(1):9– 14. doi: 10.1038/s41443-018-0060-4

  29. Pagano MJ, Fazio AD, Levy A, RoyChoudhury A, Stahl PJ. Age, Body Mass Index, and Frequency of Sexual Activity are Independent Predictors of Testosterone Deficiency in Men with Erectile Dysfunction. Urology. 2016; 90:112–8. doi: 10.1016/j.urology.2015.12.030

  30. Dozio E, Barassi A, Dogliotti G, Malavazos AE, Colpi GM, D’Eril GVM, et al. Adipokines, Hormonal Parameters, and Cardiovascular Risk Factors: Similarities and Differences Between Patients with Erectile Dysfunction of Arteriogenic and Nonarteriogenic Origin. J Sex Med. 2012;9(9):2370–7. doi: 10.1111/j.1743- 6109.2012.02781.x

  31. Nemes S, Jonasson JM, Genell A, Steineck G. Bias in odds ratios by logistic regression modelling and sample size. BMC Med Res Methodol. 2009;9(1):56. doi: 10.1186/1471- 2288-9-56.




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