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2020, Number 1

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Acta Med 2020; 18 (1)

Prevalence of hypovitaminosis D in a high socioeconomic population and its association with different nosological entities

Arellano AG, Marín SE, Jonguitud DDV, Domínguez CLG

Language: Spanish
References: 45
Page: 11-16
PDF size: 174.30 Kb.


ABSTRACT

Introduction: Vitamin D is considered a prohormone with pleiotropic effects, its deficiency has high prevalence; related not only with rickets and osteomalacia, but with a diabetes increased risk, cardiovascular, oncological, infectious and autoimmune diseases. To value in an observational, retrospective cohort study, vitamin D levels in a high socio-economic population and its association with established clinical diagnoses. Material and methods: patients between 20 and 80 years old who underwent quantification of vitamin D 25-OH by the chemiluminescence, it deficiency was considered when the quantificacation was lower than 30.0 ng/mL; correlating with diagnoses established in patients. Results: Universe of 90 patients, 60 the female gender (66.6%); reduction of normal values in 57 cases (63.3%) with mean and SD of de 22.8 ± 5.6 ng/mL; observing association with diabetes (OR = 1.19), osteoporosis (OR = 0.95), arterial hypertension (OR = 0.58), hypercholesterolemia (OR = 0.28), chronic kidney disease (OR = 0.20), and others entities. Conclusions: The levels of 25-OH Vitamin D were below normal in 2/3 of the studied sample, associated with several diseases, in this study only with diabetes mellitus is found as a risk factor, the association with the rest of the entities studied is not conclusive.


REFERENCES

  1. Christakos S1, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am. 2010; 39: 243-253.

  2. Dusso AS, Brown AJ, Slatopolky E. Vitamin D. Am J Physiol Renal Physiol. 20005; 289: F8-28.

  3. Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G, Ragi-Eis S et al. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med. 2006; 260: 245-254.

  4. Reichrath J, Lehamann B, Carlberg C, Varani J Varani J, Zouboulis CC. Vitamins as hormones. Horm Metab Res. 2007; 39: 71-84.

  5. Forrest KY, Sthuhldreher WL. Ptrevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011; 31: 48-54.

  6. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and association of 25-hydroxyvitamin D deficiency in US children. NHANES 2001-20004. Pediatrics. 2009; 124: e362-370.

  7. Adams JS, Hewison M Update in vitamin D. J Clin Endocrinol Metab. 2010: 95: 471-478.

  8. Ochoa-Correa EC, García-Hernández PA, Villarreal-Pérez JZ, Treviño-Garza C, Rodríguez-Balderrama I, Martínez-de Villarreal LE et al. Deficiencia de vitamina D en madres y neonatos mexicanos. Gaceta Médica de México. 2017; 153: 559-565.

  9. Holick FM, Chen CT. Vitamin D deficiency: a worldwide problem with health consequences. Amer J clinical Nutr. 2008; 87: 1080-1086.

  10. Adams JS, Hewison M Update in vitamin D. J Clin Endocrinol Metab. 2010: 95: 471-478.

  11. Kochupillai N. The physiology of vitamin D: current concepts. Indian J Med Res. 2008; 127: 256-262.

  12. Bray M, Hagberg JM, Perusse L, Rankinen T, Roth S, Wofarth B, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc. 2009; 41: 34-72.

  13. Plum L, DeLuca H. The functional metabolism and molecular biology of vitamin D. Clinical Reviews in bone and mineral metabolism. 2009; 7: 20-41.

  14. Bloomgarden ZT. American Diabetes Association’s 57th annual advanced postgraduate course: disbetes risk; vitamin D, polycystic ovary syndrome, and obstructive sleep apnea. Diabtes Care. 2011; 34: e1-6.

  15. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabtelogia. 2008; 51: 1391-1398.

  16. Rocha ML, Baldan da Silva D, Souza AL, Chaim AE, Chaim AE, Pavin EJ, Monte Alegre S. Body composition and metabolic profile in adults with vitamin D deficiency. Rev Nut. 2017; 30: 419-430

  17. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008; 93: 512-517.

  18. Mirhosseini N, Vatanparast H, Mazidi M, Kimball MS. Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis. J Endo Soc. 2018; 2: 687-709.

  19. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007; 92: 2017-2029.

  20. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among EUA adults. Diabetes Care. 2005; 28: 1228-1230.

  21. Mathiu C, Gysemans C, Giulietti A, Bouillon. Vitamin D and diabetes. Diabetologia. 2005; 48: 1247-1257.

  22. Chiu Es, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistence and beta cell dysfunction. Am J Clin Nutr. 2004; 79: 820-825.

  23. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev. 2009; 22: 82-92.

  24. Mirhosseini N, Vatanparast H, Mazidi M, Kimball MS. Vitamin D supplementation, glycemic control, and insulin resistance in prediabetics: A meta-Analysis. J Endo Soc. 2018; 2: 687-709.

  25. Scragg R. “Role of vitam D for cardiovascular health”. In Holick MF (ed). Vitamin D physiology, molecular biology, and clinical applications. 2a ed. Boston, Humana Press; 2010: 921-936.

  26. Zittermann A, Schleithoff SS Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2005; 94: 483-492.

  27. Li YC. “Vitamin D, renin, and blood pressure”. In: Holick MF, ed. Vitamin D physiology, molecular biology, and clinical applications. 2a. ed. Boston, Humana Press; 2010: 937-953.

  28. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W et al. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin system. Am J Physiol Endocrinol Metb. 2005; 288: E125- 132.

  29. Kim HW, Park CW, Shin YS, Kim YS, Shin SJ, Kim Y et al. Calcitriol regresses cardiac hypertrophy and QT dispersion in secondary hyperparathyroidism on hemodialysis. Nephron Clin Pract.2006; 102: c21-29.

  30. Bischoff-Ferrari HA, Fischer K, Orav EJ, Dawson-Hughes B, Meyer U, Chocano-Bedoya PO, Meyer OW et al. Statin use and 25-hydroxyvitamin d blood level response to vitamin d treatment of older. Adults J Am Geriatr Soc. 2017; 65 (6): 1267-1273.

  31. Pereda CA, Nishisshinya BM. ¿Existe relación entre los niveles séricos de vitamina D (25OHD) y el dolor musculoesquelético relacionado con la ingesta de estatinas? Revisión sistemática. Reumat Clin. 2016; 12: 303-364.

  32. Mansur JL. Efecto de las estatinas sobre la concentración de vitamina d sérica. Arch Med. 2018; 14: 1-4.

  33. Holick MF. Vitamin D exraskeletal health. Endocrinol Metab Clin North Am. 2010; 38: 381-400.

  34. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol. 2007; 103: 708-711.

  35. Wang S. Epidemiology of Vitamin D in health and disease. Nutr Res Rev. 2009; 22: 188-203.

  36. Husein MA, Al-ayed BM, Al-rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim). 2001; 7: 267-275.

  37. Torresan ME, Biasatti C, Cáceres LM, Minniti VP. Estatus de vitamina D en mujeres adultas hipotiroideas controladas. Rev Arg Endocrin Metab. 2017; 54: 50-54

  38. Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Dankó K et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011; 8: 243-247

  39. Yasuda T, Okamoto Y, Hamada N, Miyashita K, Takahara M, Sakamoto F, Miyatsuka T et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine. 2012; 42: 739-741.

  40. Blaney PG, Albert JP, Proal A. Vitamin D Metabolites as Clinical Markers in Autoimmune and Chronic Disease. Ann N Y Acad Sci. 2009; 1173: 384-390

  41. Mejía J, Reyna VE, Andrade AM, Lozada M. Suplementación de vitamina D y perfil lipídico en mujeres con síndrome de ovarios poliquísticos y deficiencia de vitamina D. Medicina Reproductiva y Embriología Clínica. 2018; 5: 123-131.

  42. Goodwill MA, Szoeke C. A Systematic Review and meta-analysis of the effect of low vitamin D on cognition. J Am Geriatr Soc. 2017; 65: 2161-2168.

  43. Hamilton B. Vitamin D and Human Skeletal Muscle. Scand J Med Science Sport. 2010; 20: 182-190.

  44. Gallego GD, Mejía MS, Martínez SL, Rendón DM. Hipovitaminosis D: una visión desde la clínica y la biología molecular. Med UIS. 2017; 30: 45-56.

  45. Nair P, Venkatesh B. Vitamin D Deficiency and supplementation in critical illness: the known knowns and known unknowns. Crit Care. 2018; 22: 276.




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