2019, Number 4
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Rev Cubana Pediatr 2019; 91 (4)
Malignant head and neck tumors in pediatric patients
Forteza SM, García SD, Pérez TM, Alert SJ, Reno CJ
Language: Spanish
References: 24
Page: 1-12
PDF size: 362.11 Kb.
ABSTRACT
Introduction: Malignant tumors of the head and neck include several histological subtypes and the prognosis depends on their anatomical location.
Objective: To describe the clinical characteristics and treatment of patients diagnosed with malignant head and neck tumors.
Methods: A descriptive, longitudinal and retrospective study was carried out from January 1, 2005 to December 31, 2017 at the Oncopediatrics service in the National Institute of Oncology and Radiobiology, according to demographic, clinical and therapeutic variables. Patients were identified from the databases of the hospital registry of the above mentioned institute. All patients with head and neck tumors that had a histological diagnosis were selected.
Results: 73 patients were identified, with a slight predominance of females (60.3%), with a mean age of 12 years (range between 0 and 18 years). The most frequent histological type was thyroid carcinoma (35.6%), followed by rhabdomyosarcomas (27.3%). The most used treatment was surgery (38.3%) followed by the combination of surgery plus radiotherapy and chemotherapy (22%).
Conclusions: Tumors of the head and neck are infrequent. The treatment of choice is total resection, accompanied by radiotherapy and chemotherapy, depending on the histological type and the clinical stage.
REFERENCES
Rehbein J, Becerra F, Fernández A, Niklander S, Marshall M, Esguep. Cáncer oromaxilofacial en niños: parte II. Tumores odontogénicos y de glándulas salivales malignos. Int J Odontostomatol. 2016; 10(2):277-82.
Registro Nacional del Cáncer. Sección independiente para el control del cáncer (SICC). Último reporte, 2012. La Habana: MINSAP; 2013.
Veitía D, Liuzzi J, Correnti M, Ávila M, De Guglielmo Z, Siso S, et al. Detección de virus Epstein-Barr en pacientes con cáncer de cabeza y cuello. Rev Venez. Oncol. 2015; 27(3):149-55.
Bahadur, G. Age definitions, childhood and adolescent cancers in relation to reproductive issues. Human Reproduction. 2000;15(1):227.
Ministerio de Salud Pública. Anuario estadístico de salud.2015. La Habana: MINSAP; 2016.
Alcalde Navarrete JM. Saber más sobre los tumores de cabeza y cuello. 2013; MEDISAN. 2012;21(12). Acceso: 23/05/2017. Disponible en: http://www.cun.es/enfermedades-tratamientos/enfermedades/tumores-cabeza-cuello
Ries LA, Smith MA, Gurney JG. Cancer incidence and survival among children and adolescents. United States; SEER Program 1975-1995. Bethesda, Md: National Cancer Institute, SEER Program; 1999.
Jason Qian Z, Jin MC, Meister KD [abstract]. Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 1973-2013. JAMA Otolaryngol Head Neck Surg. 2019;145(7):593.
Becerra F, Rehbein J, Fernández A, Marshall M, Esguep A. Cáncer oromaxilofacial en niños: parte I. Tumores malignos de tejido duro. Int J Odontostomatol. 2015;9(2):313-9.
Rizzi M. Historia del carcinoma laríngeo en la niñez, a propósito de un caso descripto por Alejandro Volpe en Uruguay en el año 1920. An Otorrinolaringol Urug. 2011;88:34-46.
Muenscher A, Feucht HH, Kutta H, Tesche S, Wenzel S. Integration of human papilloma virus type 26 in laryngeal cancer of a child. Auris Nasus Larynx. 2009;36(2):232-4. doi: 10.1016/j.anl.2008.05.011. Epub 2009 Jul 14.
Parfenov M. Characterization of HPV and host genome interactions in primary head and neck cancers. PNAS. 2014;111(43):15544-9.
Fernández A, Becerra F, Rehbein J, Acuña S, Somarriva C, Cáceres A, et al. Cáncer bucomaxilofacial en niños III: Tumores malignos del tejido blando. Int J Odontostomat. 2017;11(4):387-92.
Qaisi M, Eid I. Pediatric head and neck malignancies. Oral MaxillofacSurg Cli. North Am. 2016;28(1):11-9.
Lilja-Fischer JK, Schrøder H, Nielsen VE. Pediatric malignancies presenting in the head and neck. Int J PediatrOtorhinolaryngol. 2018;118:36-41. doi: 10.1016/j.ijporl.2018.12.009.
Sengupta S, Pal R, Samnath S, etal. J Indian Associat Pediatric Surgeons. 2009;14 (4): 00 -3.
Reilly K, Kim A, Pena MT, Dong TA. Rhabdomyosarcoma of the Head and Neck in children; Review and update. Internat J Pediatric Otorhinolaryngol. 2015;(9:1477- 83.
Chadha NK, Forte V. Pediatric head and neck malignancies. Pediatric Otolaryngol Head Neck Surg. 2009;17:471-6.
Adisa AO, Adeyemi BF, Oluwasola AO, Bamidele K, Akang EU, Lawoyin JO. Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria. Head Face Med. 2011;7(9). Acceso: 04/05/2019. Disponible en: https://head-face-med.biomedcentral.com/articles/10.1186/1746-160X-7-9
Nobis P, Rholeder NH, Wolff KD. Head and Neck Salivary Gland Carcinoma selective neck dissection, yes or no? J Oral Maxillofacial Surgery.2014;205-10.
Albright JT, Topham AK, James SR. Pediatric head and neck malignancies US incidence and trends over two decades. Otolaryngol Head Neck Surg. 2006;135(3):451-7.
American Academy of Otolaryngology- Head and Neck Surgery. Pediatric Thyroid Cancer. Acceso: 01/05/2019. Disponible en: https://www.entnet.org/content/pediatric%20thyroid%20cancer,%22014.h
Abdulai AE, Nuamah IK, Gyasi RK. Head and neck tumours in Ghanaian children. A 20 year review. Int J Oral Maxillofac Surg. 2012;41(11):1378-82. doi: 10.1016/j.ijom.2012.06.004
Picardo A, Arecco F, Puntoni M, Foppiani L, Cabria M, Corvisceri S, et al. Focus on high risk DTC patients: High postoperative serum thyroglobulin level is a strong predictor of disease persistence and is associated to progression free survival. Clin Nucl Med. 2013;38(1):18-24. doi: 10.1097/RLU.0b013e318266d4d8.