2006, Number S2
<< Back Next >>
Rev Med Inst Mex Seguro Soc 2006; 44 (S2)
Gas transportation through perfluorocarbons
Cabrales P
Language: Spanish
References: 15
Page: 119-122
PDF size: 75.71 Kb.
ABSTRACT
Perfluorocarbons (PFC) are alkanes where hydrogen atoms have been added or replaced partially by fluorine atoms. PFC are characterized by weak intermolecular forces, which give the PFC high solubility to gases. PFC and their emulsions can be used to oxygenate tissues
in vivo or
in vitro, and to carry and distribute other gases or compounds with high facility. This work explores the applicability of PFC as a gas transporter in different experimental models. In this respect, the PFC provides a unique pharmacological solution for the safe delivery of gases.
REFERENCES
Van De Water JM, Kagey KS, Miller IT et al. Response of the lung to six to 12 hours of 100 per cent oxygen inhalation in normal man. N Engl J Med 1970; 283: 621-626.
Tinits P. Oxygen therapy and oxygen toxicity. Ann Emerg Med 1983; 12: 321-328.
Keipert PE, Otto S, Flaim SF et al. Influence of perflubron emulsion particle size on blood half-life and febrile response in rats. Artif Cells Blood Substit Immobil Biotechnol 1994; 22: 1169-1174.
Eckstein EC, Koleski JF, Waters CM. Concentration profiles of 1 and 2.5 microns beads during blood flow. Hematocrit effects. ASAIO Trans 1989; 35: 188-190.
Faithfull NS. Oxygen delivery from fluorocarbon emulsions-aspects of convective and diffusive transport. Biomater Artif Cells Immobil Biotechnol 1992; 20: 797-804.
Miyakawa S, Yamanashi H, Kobayashi K et al. Prebiotic synthesis from CO atmospheres: implications for the origins of life. Proc Natl Acad Sci USA 2002; 99: 14628-14631.
Weaver LK, Hopkins RO, Elliott G. Carbon monoxide poisoning. N Engl J Med 1999; 340: 1290. (author reply 2).
Ryter SW, Otterbein LE, Morse D, Choi AM. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem 2002; 234-235: 249-263.
Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: Unleashing the protective properties of heme. Trends Immunol 2003; 24: 449-455.
Archer S. Measurement of nitric oxide in biological models. Faseb J 1993; 7: 349-360.
Nathan C. Nitric oxide as a secretory product of mammalian cells. Faseb J 1992; 6: 3051-3064.
Ignarro LJ. Nitric oxide-mediated vasorelaxation. Thromb Haemost 1993; 70: 148-151.
Wink DA, Darbyshire JF, Nims RW et al. Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction. Chem Res Toxicol 1993; 6: 23-27.
Liu X, Miller MJ, Joshi MS, et al. Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes. Proc Natl Acad Sci USA 1998; 95: 2175-2179.
Rafikova O, Sokolova E, Rafikov R, Nudler E. Control of plasma nitric oxide bioactivity by perfluorocarbons: physiological mechanisms and clinical implications. Circulation 2004; 110: 3573-3580.